A randomized controlled trial to determine the effects of humidified carbon dioxide insufflation during thoracoscopy

Mouton, Wolfgang G.; Bessell, J. R.; Pfitzner, J.; Dymock, R. B.; Brealey, John; Maddern, Guy J.

doi:10.1007/s004649900994

Cited by 31 publications

(31 citation statements)

References 18 publications

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“…In the meantime, strategies that preserve physiologic peritoneal function should be considered for further clinical study. These include the use of heated and humidified gas or inert insufflation gases such as helium [7,32,37].…”

Section: Implications For Laparoscopic Cancer Surgerymentioning

confidence: 99%

“…However, this still is significantly lower than normal intraperitoneal or core temperature. Mouton et al [32] demonstrated using a pig thoracoscopic model that dry gas insufflation resulted in greater ultrastructural change to the pleura than humidified gas insufflation [32]. Changes observed on scanning electron microscopy in the dry gas insufflation group (Fig.…”

Section: The Influence Of Humidity and Warmingmentioning

confidence: 99%

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Pneumoperitoneum and peritoneal surface changes: a review

Neuhaus

Watson

2004

Surg Endosc

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Ultrastructural, metabolic, and immune alterations are observed at the peritoneal surface in response to a pneumoperitoneum. Experimental evidence suggests that these changes are carbon dioxide-specific effects. The consequences of these alterations to the local peritoneal environment are not well understood, but they may facilitate tumor implantation within the peritoneal cavity and adversely affect the ability to clear intraperitoneal infections. Further investigation into this area is warranted.

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Section: Implications For Laparoscopic Cancer Surgerymentioning

confidence: 99%

Section: The Influence Of Humidity and Warmingmentioning

confidence: 99%

Pneumoperitoneum and peritoneal surface changes: a review

Neuhaus

Watson

2004

Surg Endosc

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“…The exact relation between dry gas and postoperation pain is not yet determined, but other animal studies have observed that dry gas insufflation is implicated in ultrastructural damage to exposed membranes, an effect that was not seen with the use of humidified gas [25]. We believe that this may be a mechanism mediating postoperation pain.…”

Section: Humidity Of Gasmentioning

confidence: 82%

Pain after laparoscopy

et al. 1999

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On the basis of the factors implicated in postlaparoscopy pain, the following recommendations can be made in an attempt to reduce such pain: emphathically consider each patients' unique sociocultural and individual pain experience; inject port sites with local anesthesia at the start of the operation; keep intra-abdominal pressure during pneumoperitoneum below 15 mmHg, avoiding pressure peaks and prolonged insufflation; use humidified gas at body temperature if available; use nonsteroidal anti-inflammatory drugs at the time of induction; attempt to evacuate all intraperitoneal gas at the end of the operation; and use drains only when required, rather than as a routine.

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“…Davis and colleagues stated that their references 2, 8, and 20 were exaggerated hypothermia experiments [2,8,11]. We do not find that these research efforts lead to erroneous conclusions.…”

mentioning

confidence: 77%

“…The other referenced studies were conducted to compare cold dry gas to warm humidified gas. All findings showed statistically more hypothermia in the cold dry gas group [8,11].…”

mentioning

confidence: 79%