A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus

Yoke, Poon Choy; Tin, Goh Bee; Kim, Myung-Jin; Rajaseharan, Annabelle; Ahmed, Shahid; Thongprasom, Kobkan; Chaimusik, Mantharop; Suresh, Shirley; Machin, David; Bee, Wong Hwee; Seldrup, J

doi:10.1016/j.tripleo.2005.09.006

Cited by 89 publications

(106 citation statements)

References 19 publications

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“…All included studies were performed in secondary care. One study [14] was a multicentre study. The diagnosis of OLP was confirmed clinically in all studies and histologically in all but one [20].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…[18] all the participants received a systemic steroid, and in another study [28] the experimental intervention was compared with intralesional steroid. Of the 29 trials using steroid as an active intervention, clobetasol was used in nine trials [4,7,10,11,19,22,23,27,35], triamcinolone in ten trials [4,5,[13][14][15][16]20,28,31,36], flucinolone in two trials [6,8], dexamethasone in two trials [29,34], prednisolone in one trial [18], fluticasone in one trial [9] & betamethasone in two trials [9,20]. Systemic prednisolone was used in one trial [18].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Topical tacrolimus was used in four trials [13,22,23,35], topical pimecrolimus in four trials [15,17,24,33], topical cyclosporine in four trials [3,5,14,16].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Clinical response was measured by eleven trials [6][7][8][9][10][14][15][16]21,27,30,31] using the clinical grading by Thongprasom 1992 consisting of a six-point ordinal scale, four trials [17,19,22,24] used a different clinical grading scale with scores 1 to 4. Tel Aviv San Francisco scale was used in one trial [32].…”

Section: Secondarymentioning

confidence: 99%

“…Six studies [14,15,17,18,24,33] performed intention-to-treat (ITT) analyses. Of these, except Yoke and Gorouhi, the rest enrolled only erosive oral lichen planus [14,15].…”

Section: Incomplete Outcome Datamentioning

confidence: 99%

See 4 more Smart Citations

Medical Management of Oral Lichen Planus: A Systematic Review

Suresh

Krunal²,

Desai³

et al. 2016

JCDR

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…Topical tacrolimus was used in four trials [13,22,23,35], topical pimecrolimus in four trials [15,17,24,33], topical cyclosporine in four trials [3,5,14,16].…”

Section: Study Characteristicsmentioning

confidence: 99%

Section: Secondarymentioning

confidence: 99%

“…Six studies [14,15,17,18,24,33] performed intention-to-treat (ITT) analyses. Of these, except Yoke and Gorouhi, the rest enrolled only erosive oral lichen planus [14,15].…”

Section: Incomplete Outcome Datamentioning

confidence: 99%

See 3 more Smart Citations

Medical Management of Oral Lichen Planus: A Systematic Review

Suresh

Krunal²,

Desai³

et al. 2016

JCDR

View full text Add to dashboard Cite

Interventions for treating oral lichen planus

Thongprasom

Carrozzo

Furness

et al. 2011

Cochrane Database of Systematic Reviews

140

131

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus

Cited by 89 publications

References 19 publications

Medical Management of Oral Lichen Planus: A Systematic Review

Medical Management of Oral Lichen Planus: A Systematic Review

Interventions for treating oral lichen planus

Interventions for treating oral lichen planus: corticosteroid therapies

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