A randomized, crossover, open label pilot study to evaluate the efficacy and safety of Xalatan ® in comparison with generic Latanoprost (Latoprost) in subjects with primary open angle glaucoma or ocular hypertension

Are generic topical prostanoids the way forward in the care of glaucoma patients? – Yes

“…8 Another study from India showed a significant difference in intraocular pressure between Latoprost and Xalatan at week 12 but none at week 24. 9 A larger 12-week study in Italy confirmed the noninferiority of generic latanoprost. 10 With regard to adverse events, Japanese authors have described the development of a corneal epithelial disorder following administration of Laparoprost eye drops.…”

Evaluation of investigator bias in industry-funded clinical trials of latanoprost

“…The 33 IOP data sets from 29 articles (4 studies were cross-over designs and contributed 2 IOP data sets each) investigating latanoprost provided 1-month data, 4,6,8,9, and 14 data sets from 13 articles (1 study was a cross-over design and contributed 2 data sets) provided 3-month data. [7][8][9][10]15,18,[37][38][39][40][41][42][43] Details of the latanoprost studies are provided in Table 2. Of the 17 studies categorized as nonindustry, 3 disclosed funding sources that included Red Temática de Investigación en Bias in industry-funded trials-Jinapriya et al…”

Efficacy and Safety of Glaucoma Patients' Switch from a 2% Dorzolamide/0.5% Timolol Fixed-Combination Brand-Name Drug to Its Generic Counterpart

“…The difference in IOP lowering could be caused by the difference in adjuvants. 21 The safety of the 2 drugs was evaluated based on their discomfort symptoms and discomfort scores. There were no significant differences in terms of the discomfort symptoms and discomfort score in both groups.…”