A Randomized, Double-blind, Placebo-controlled Clinical Study to Investigate the efficacy of Herring Roe Oil for treatment of Psoriasis

Abstract

The effect of herring roe oil capsules was tested in patients with psoriasis. This study demonstrates a positive effect on psoriasis. Disease severity is important when determining the appropriate treatment of psoriasis patients. In recent years, several new drugs have become available for the treatment of severe psoriasis whereas there have been few treatment advances for patients with milder psoriasis. This study demonstrates promise for herring roe oil as a safe treatment option in patients with non-severe psoriasis.The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration of treatment. The observed beneficial effects in patients with psoriasis vulgaris using herring roe oil as a dietary supplement prompted this investigation. This randomised, double-blind and placebo-controlled study was designed and performed to explore the efficacy and safety of herring roe oil supplementation in 64 patients with plaque psoriasis (ClinicalTrials.gov: NCT03359577). The primary end-point was comparing the change in mean Psoriasis Area Severity Index (PASI) scores in the herring roe oil treatment group and the placebo group from baseline to week 26. In the intention-to-treat population, a statistically significant improvement in the mean PASI score was observed with herring roe oil compared to placebo at 26 weeks. In the recruited patient group, the measured improvement was greatest in patients with a PASI score from 5.5-9.9 at baseline.

The Effect of Lifestyle Changes on Disease Severity and Quality of Life in Patients with Plaque Psoriasis: A Narrative Review

“… 35 The daily intake of 10 capsules of herring roe oil in another blinded RCT (64 patients; 26 weeks) resulted in a mean delta PASI of −1.8, versus a mean delta PASI of −0.6 in the placebo group (p=0.045) after 26 weeks. 36 A smaller blinded RCT (n=32) did not find statistical differences in total BSA change at week 12 between patients taking 10 fish oil capsules daily versus a placebo. However, a very subtle, but statistically significant difference in erythema score was found between the groups, in favor of the fish oil group compared to the control group (erythema −1.1 vs - 0.2, resp.…”

“… I: 10 capsules herring roe oil (containing fatty acids EPA and DHA) daily C: Placebo: 10 capsules coconut oil daily Stable topical anti-psoriatic treatments. Tveit et al 36 (2020) X X X 64 26 wks Y N Mean ± SD Δ PASI at wk 26: I −1.8 ± 2.6 C −0.6 ± 1.8 (p=0.045). No differences in PASI50, BSA or PSGA.…”

Long Term Efficacy and Safety of Herring Roe Oil in the Treatment of Psoriasis, a 39-week Open-label Extension Study

“…In the preceding randomised period (26 weeks), a statistically significant mean reduction in PASI in the HROgroup versus the placebo group was observed [6]. The clinical relevance of the observed mean PASI improvement [11,12] during the randomised period could not be readily concluded.…”

“…We explored the efficacy of HRO in a randomised, double blind, placebo controlled clinical study in psoriasis patients with baseline PASI score < 10 [6]. The randomised study period lasted for 26 weeks and all eligible patients were invited to continue a 39-week, open-label, active treatment period.…”

Association Between Daily Dietary Eicosatetraenoic Acid Intake and the Lower Risk of Psoriasis in American Adults

“…Numerous studies have consistently revealed their crucial roles in inhibiting chronic diseases, including inflammatory, carcinogenic, adipogenic, diabetogenic, and atherogenic diseases. 8 Moreover, previous studies have also found that supplementation of n3 PUFA (rich in EPA and DHA) improves the condition of psoriasis, 3,[9][10][11][12] but other studies have not found similar results. 13,14 More researches are needed to confirm the relationship between n3 PUFA intakes and psoriasis.…”