A randomized, double-blind, placebo-controlled comparison of the effect of nitrofurantoin monohydrate macrocrystals on the development of urinary tract infections after surgery for pelvic organ prolapse and/or stress urinary incontinence with suprapubic catheterization

Rogers, Rebecca G.; Kammerer-Doak, Dorothy; Olsen, Ambre L.; Thompson, Peter; Walters, Mark D.; Lukacz, Emily S.; Qualls, Clifford

doi:10.1016/j.ajog.2004.03.088

Cited by 60 publications

(53 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We focused on patients undergoing TVT procedure who were scheduled to have postoperative bladder drainage for 24 h to select a welldefined, high-risk group that can considerably benefit from chemoprophylaxis. A previous study showed that antibiotic prophylaxis with a daily dose of 100 mg of nitrofurantoin monohydrate decreased UTI compared with placebo after pelvic organ prolapse and/or urinary incontinence surgery with suprapubic catheterization [21].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic single-dose prulifloxacin for catheter-associated urinary tract infection after tension-free vaginal tape procedure

et al. 2006

View full text Add to dashboard Cite

The purpose of the study was to evaluate whether antibiotic prophylaxis with a single dose of prulifloxacin after tension-free vaginal tape (TVT) procedure decreases catheter-associated urinary tract infections (UTIs). Patients undergoing TVT procedure receiving a single dose of prulifloxacin (600 mg) 10 h before catheter removal (n=54) were compared with historical controls who have had no treatment (n=60). All patients had an indwelling urethral catheter in situ for 24 h. Urine specimens for culture were collected preoperatively, before Foley removal, and 7 days postoperatively in both groups. Main outcome measures were significant bacteriuria and symptomatic UTI at catheter removal and 1 week postoperatively. No patient had a positive urine culture in the prulifloxacin group compared with 14 (23.3%) in the control group at catheter removal (P=0.0001). Ten out of 14 (71.4%) women with a positive catheter urine culture had a symptomatic UTI. One week after surgery no difference was found in the rate of significant bacteriuria between groups. Our data suggest that a prophylactic single dose of prulifloxacin could help to reduce the rate of symptomatic and asymptomatic UTIs after short-term urethral catheterization in women undergoing TVT procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Prophylactic single-dose prulifloxacin for catheter-associated urinary tract infection after tension-free vaginal tape procedure

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Brouwer and Hoogkamp-Korstanje did not find a statistically significant difference regarding development of UTI in patients receiving single-dose ceftriaxone or cefuroxime plus metronidazole prophylaxis [15]. In 2004, Rogers et al, in a total of 435 patients of which 59% underwent a retropubic urethropexy and in whom suprapubic catheterization was used, found that a preoperative dose of cephalosporin plus postoperative nitrofurantoin monohydrate was associated with less development of UTI than the use of preoperative cephalosporin and placebo (7.2% vs 19.8%) [16]. Finally, in 2007, Cormio et al compared two ultra-short-term prophylaxis schemes (amoxicillin-clavulanic acid versus cefazolin) which both showed similar results regarding effectiveness as 6.8% and 4.4% were the UTIs in each group respectively [17].…”

Section: Comparisons Between Two Antibiotic Regimensmentioning

confidence: 99%

Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review

et al. 2008

View full text Add to dashboard Cite

We evaluated the prevalence of urinary tract infection (UTI) after pelvic floor operations for non-malignant etiology and the effectiveness of antibiotic prophylaxis. This was made possible by a review of the evidence from relevant randomized controlled trials (RCTs). Nineteen out of 879 initially identified studies met the criteria for inclusion in our review. Four RCTs compared an antibiotic prophylactic regimen with placebo, 11 two different prophylactic antibiotic regimens, and four had three different treatment arms. Among placebo recipients undergoing pelvic floor surgery, 10-64% developed UTI. In contrast, UTI after pelvic floor gynecological surgery occurred in 0-15% of the patients who received cephalosporins as antibiotic prophylaxis; the likelihood for postoperative UTI was higher for patients receiving cotrimoxazole (28%), ampicillin/sulbactam (13.6%), metronidazole plus ampicillin (20%), metronidazole (10-22.7%), or ciprofloxacin (27.2%). The use of a cephalosporin as perioperative antimicrobial prophylaxis is the optimal regimen in preventing UTIs after pelvic floor surgery.

show abstract

“…8 Four sites in this multicenter trial also recruited women to participate in a sexual function study, which has also been described previously. 9 These women form the present study population.…”

Section: Methodsmentioning

confidence: 99%

Posterior repair and sexual function

Komesu

Rogers

Kammerer-Doak

et al. 2007

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

OBJECTIVE-The purpose of this study was to determine the effect of posterior repair (PR) on sexual function in patients who have undergone incontinence and/or pelvic reconstructive surgery.STUDY DESIGN-A cohort study of women who underwent incontinence and/or prolapse surgery was performed. Participants completed the pelvic organ prolapse urinary incontinence sexual questionnaire (PISQ) before and after the operation. PISQ scores were compared between women who underwent PR and women who did not. RESULTS-Of 73 study participants, 30 women underwent PR; 43 women did not (no PR).Although there was no difference in dyspareunia between groups pre-op, dyspareunia prevalence post-op was significantly lower in the no PR group. Preoperative PISQ scores were similar between groups. After the operation, both groups significantly improved their PISQ scores, without a difference between groups.CONCLUSION-Although the incidence of dyspareunia differed between PR and no PR groups, overall improvement in sexual function was reflected in improved total PISQ scores that occurred irrespective of PR performance. Keywords dyspareunia; incontinence; posterior repair; prolapse; sexual function Posterior compartment defects arise from abnormalities in rectovaginal connective tissue and its attachments within the pelvis. 1 Repair of this defect includes traditional posterior colporrhaphy, which is performed by plicating the patient's native rectovaginal connective tissue in the midline, or site specific posterior colporrhaphy, which is performed by plicating individual breaks in rectovaginal tissue. 1,2 Controversy exists whether posterior repair (PR) is associated with diminished sexual function or dyspareunia. Some authors have reported increased rates of dyspareunia after PR, whereas other authors have not. [3][4][5][6][7] Some authors have concluded that PR causes sexual dysfunction as a result of its association with dyspareunia. [3][4][5] Our objective was to evaluate prospectively pre-to postoperative changes in sexual function in women who had undergone PR compared with women who did not. MATERIALS AND METHODSThis analysis is based on a previously reported population of women enrolled in a randomized controlled trial that evaluated antibiotic prophylaxis for urinary tract infections after urinary incontinence and/or pelvic organ prolapse surgery. 8 Four sites in this multicenter trial also recruited women to participate in a sexual function study, which has also been described previously. 9 These women form the present study population. We studied sexual function using a condition-specific, validated sexual function questionnaire, the Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire (PISQ). 10 This cohort study compared women who underwent PR with the group of women who did not undergo PR (no PR). Institutional review board approval was given, and written informed consent was obtained.Sexually active patients who had undergone pelvic reconstructive and/or incontinence procedures agreed to answer the PISQ...

show abstract

A randomized, double-blind, placebo-controlled comparison of the effect of nitrofurantoin monohydrate macrocrystals on the development of urinary tract infections after surgery for pelvic organ prolapse and/or stress urinary incontinence with suprapubic catheterization

Cited by 60 publications

References 13 publications

Prophylactic single-dose prulifloxacin for catheter-associated urinary tract infection after tension-free vaginal tape procedure

Prophylactic single-dose prulifloxacin for catheter-associated urinary tract infection after tension-free vaginal tape procedure

Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review

Posterior repair and sexual function

Contact Info

Product

Resources

About