A randomized, double-blind, single-dose, crossover clinical trial of the onset and duration of protection from exercise-induced bronchoconstriction by formoterol and albuterol

Protective effect of a low single dose inhaled steroid against exercise induced bronchoconstriction

“…The protective effect of a low single dose ICS against EIB may be clinically profitable for mild asthmatic children who do not require maintenance ICS therapy but with EIB. Bronchoprotection of salbutamol against EIB is, although stronger, short lived and subject to tachyphylaxis …”

“…Bronchoprotection of salbutamol against EIB is, although stronger, short lived and subject to tachyphylaxis. [19][20][21] There is no agreement regarding the nature of the exact stimulus that causes EIB. One assumes that exercise induced hyperpnea dries the epithelium, leading to hyperosmolarity of the airway surface fluid.…”

Long-acting β-agonists and exercise

“…8 However, an examination of 20 adults given salmeterol twice daily for 4 weeks showed that although a bronchodilator effect was maintained, a decrease in bronchoprotective effect for exercise-induced bronchospasm at 14 and 29 days of administration that was most prominent 9 hours after the dose was demonstrated. 9 This loss of bronchoprotective effect has also been reported to occur even with use of inhaled corticosteroids.…”

An Evaluation of Levalbuterol Hfa in the Prevention of Exercise-Induced Bronchospasm

“…Several studies have demonstrated the ability of racemic albuterol MDI to protect against EIB (11)(12)(13)(14)(15). Although the FDA has not approved levalbuterol HFA MDI to treat EIB, we were interested in evaluating the protective effect of levalbuterol in asthmatics.…”