A randomized, double‐blind trial comparing 5‐aminolaevulinic acid nanoemulsion with methyl 5‐aminolaevulinate in daylight photodynamic therapy for actinic keratosis

Szeimies, Rolf‐Markus; Calzavara‐Pinton, Piergiacomo

doi:10.1111/bjd.17867

Cited by 1 publication

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“…However, 7 days after the first PDT procedure, the intensity of pain was significantly lower in the areas treated with MAL-HCl or ALA-P (1.4 and 1.3 on average, respectively) than in the areas treated with ALA-HCl (1.8 on average). In most of the studies, patients reported more acute pain at the site of ALA-HCl application [20,[34][35][36][37][38][39]. However, in the reports by Yazdanyar et al, who compared the pain response to ALA-HCl and MAL treatment of the scalp and forehead AK lesions, no significant differences in pain intensity between these two formulations were found either during or 30 min after the completion of treatment [40].…”

Section: Discussionmentioning

confidence: 99%

Topical Photodynamic Therapy with Different Forms of 5-Aminolevulinic Acid in the Treatment of Actinic Keratosis

et al. 2022

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Photodynamic therapy (PDT) is safe and effective in the treatment of patients with actinic keratosis (AK). The aim of the study was to assess the efficacy, tolerability and cosmetic outcome of topical PDT in the treatment of AKs with three forms of photosensitizers: 5-Aminolevulinic acid hydrochloride (ALA-HCl), 5-Aminolevulinate methyl ester hydrochloride (MAL-HCl) and 5-Aminolevulinate phosphate (ALA-P). The formulations were applied onto selected scalp/face areas. Fluorescence was assessed with a FotoFinder Dermoscope 800 attachment. Skin areas were irradiated with Red Beam Pro+, Model APRO (MedLight GmbH, Herford, Germany). Applied treatments were assessed during the PDT as well as 7 days and 12 weeks after its completion. Ninety-four percent of patients rated obtained cosmetic effect excellent. The efficacy of applied PSs did not differ significantly. However, pain intensity during the PDT procedure was significantly lower in the area treated with ALA-P (5.8 on average) in comparison to the areas treated with ALA-HCl or MAL-HCl (7.0 on average on 0–10 scale). Obtained results show that ALA-P may undergo more selective accumulation than ALA-HCl and MAL-HCl. Our promising results suggest that PDT with the use of ALA-P in AK treatment may be an advantageous alternative to the already used ALA-HCl and MAL-HCl.

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Section: Discussionmentioning

confidence: 99%

Topical Photodynamic Therapy with Different Forms of 5-Aminolevulinic Acid in the Treatment of Actinic Keratosis

et al. 2022

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A randomized, double‐blind trial comparing 5‐aminolaevulinic acid nanoemulsion with methyl 5‐aminolaevulinate in daylight photodynamic therapy for actinic keratosis

Abstract: Linked Article: Räsänen et al. Br J Dermatol 2019; https://doi.org/10.1111/bjd.17311

Cited by 1 publication

References 5 publications

Topical Photodynamic Therapy with Different Forms of 5-Aminolevulinic Acid in the Treatment of Actinic Keratosis

Topical Photodynamic Therapy with Different Forms of 5-Aminolevulinic Acid in the Treatment of Actinic Keratosis

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