A Randomized, Double‐Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 1‐Year Clinical Results

Preus, Hans R.; Gunleiksrud, Therese Mehlum; Sandvik, Leiv; Gjermo, Per; Bælum, Vibeke

doi:10.1902/jop.2012.120400

Cited by 49 publications

(129 citation statements)

References 59 publications

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“…Analysis of the abstracts resulted in 95 potential articles. In the third phase, the full text articles of the remaining 95 articles were evaluated, of which 40 did not pass the inclusion criteria (Table ). Another 12 articles were excluded because they were about patients with aggressive periodontitis.…”

Section: Resultsmentioning

confidence: 99%

Non‐surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta‐analysis

Keestra

Grosjean

Coucke

et al. 2014

J of Periodontal Research

146

137

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Systemic antibiotics combined with SRP offer additional clinical improvements compared to SRP alone. Although there were no statistically significant differences, there was a trend that for initially moderate and deep pockets, metronidazole or metronidazole combined with amoxicillin, resulted in clinical improvements that were more pronounced over doxycycline or azithromycin. Additionally, there was a trend that the magnitude of the clinical benefit became smaller over time (1 year).

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Section: Resultsmentioning

confidence: 99%

Non‐surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta‐analysis

Keestra

Grosjean

Coucke

et al. 2014

J of Periodontal Research

146

137

View full text Add to dashboard Cite

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“…The data originate in an intervention trial carried out among 184 patients with severe chronic periodontitis (Preus, Gjermo, & Baelum, ; Preus, Gunleiksrud, Sandvik, Gjermo, & Baelum, ; Preus et al., ). The study protocol was approved by the Privacy Ombudsman for the Norwegian Universities (#15768) and Regional Committee for Medical Research Ethics (Oslo, Norway) (REC South East 2.2006.3573/S‐06458b ) .…”

Section: Methodsmentioning

confidence: 99%

“…Details on trial design, measuring techniques and clinical conduct can be found in Preus et al. (, , ).…”

Section: Methodsmentioning

confidence: 99%

A double‐masked Randomized Clinical Trial (RCT) comparing four periodontitis treatment strategies: 5‐year clinical results

Preus

Gjermo

Bælum

2017

J Clinic Periodontology

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“…The obvious distortion problem-especially with radiographs from the maxillary teeth [14]- its confirmation in clinical trials of comparative nature [15, 16], and the call for techniques that could correct for such distortions [15, 16], especially regarding an ongoing longitudinal clinical intervention study [23], prompted the development of the presented digital tool. It is clearly no more than a digital, more versatile version of the Schei ruler [24, 25] and Björn’s technique [26, 27] that at present may be more useful in research, i.e., longitudinal studies where radiographic images are obtained more than once over several years.…”

Section: Discussionmentioning

confidence: 99%

A new digital tool for radiographic bone level measurements in longitudinal studies

et al. 2015

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BackgroundThe reproducibility of measurements on radiographs is influenced by the techniques by which the images as well as the measurements are obtained. Thus, bias resulting from errors in the image and/or image examinations at two points in time may result in wrongful registrations of true biological or pathological changes. The aim of the present study was to propose and evaluate an indirect radiological examination technique, by which bias, when measuring radiographic bone level, could be substantially reduced as compared to the technique using direct mm measurements.MethodsA plugin to ImageJ was designed to reduce bias when measuring bone loss on radiographic images. In human dry mandibles, radiographic images of 20 teeth were obtained parallel with the tooth axis (alpha = 0) and at an angle of 30° deviation. The direct technique of measuring radiographic bone level (RBL) and the indirect, length-adjusted RBL were registered by four researchers in a double blinded fashion.ResultsWhen mean RBL measured at 0° angle was 7.0 mm, the corresponding mean RBL measured at 30° angle was 7.8 mm, signifying an 11.4 % increase (p = 0.032), whereas the mean length-adjusted RBL increased by 0.6 % (p = 0.9).ConclusionsThis study showed that the use of the original, direct technique (ImageJ) resulted in markedly biased radiographic bone level at 30° angle, while the proposed indirect length-adjusted technique (ImageJ plugin) did not.

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A Randomized, Double‐Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 1‐Year Clinical Results

Abstract: Metronidazole had a significant, adjunctive effect in patients with a metronidazole-sensitive subgingival microbiota on the clinical parameters of CAL, PD, and absence of pockets ≥5 mm.

Cited by 49 publications

References 59 publications

Non‐surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta‐analysis

Non‐surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta‐analysis

A double‐masked Randomized Clinical Trial (RCT) comparing four periodontitis treatment strategies: 5‐year clinical results

A new digital tool for radiographic bone level measurements in longitudinal studies

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