A randomized, multicenter, multivendor study of myocardial perfusion imaging with regadenoson CT perfusion vs single photon emission CT

Cury, Ricardo C.; Kitt, Therese M; Feaheny, Kathleen; Blankstein, Ron; Ghoshhajra, Brian B.; Budoff, Matthew J.; Leipsic, Jonathon; Min, James K.; Akin, Jamie; George, Richard Т. De

doi:10.1016/j.jcct.2015.01.002

Cited by 72 publications

(46 citation statements)

References 34 publications

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“…Cury et al (45) performed another multicenter trial using different vendor scanners (64, 128, 256 or 320 detector row). They enrolled 110 patients with suspected or known CAD, and also regadenoson was used as stress agent.…”

Section: Clinical Evidencementioning

confidence: 99%

“…Most of these were performed in a limited number of patients and using different scanner generations, showing high sensitivity and negative predictive value, and moderate specificity and positive predictive value. Newer single center studies have shown improved positive predictive value as well as specificity, being validated by two large multicenter trials (43)(44)(45)(46).…”

Section: Introductionmentioning

confidence: 99%

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Myocardial CT perfusion imaging for ischemia detection

Carrascosa

Capuñay

2017

Cardiovasc. Diagn. Ther.

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Section: Clinical Evidencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myocardial CT perfusion imaging for ischemia detection

Carrascosa

Capuñay

2017

Cardiovasc. Diagn. Ther.

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“…54 There are extensive CTP data favorably comparing its accuracy to ICA, MPI, and stress MRI for the detection of >50% stenosis by ICA. [55][56][57][58] The ability to reduce false-positive findings by discounting perfusion abnormalities in the distribution of normal vessels offers an advantage over the other functional tests, all of which lack an anatomic component. There are several studies comparing CTP with invasive FFR (Table 4).…”

Section: Ct Myocardial Perfusion Imagingmentioning

confidence: 99%

Fractional Flow Reserve and Coronary Computed Tomographic Angiography

Hecht

Narula

Fearon

2016

Circulation Research

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Obstructive coronary artery disease (CAD) produces symptoms and increases the risk of adverse cardiac outcomes. However, determining whether a particular coronary stenosis is responsible for causing myocardial ischemia can be challenging, even with invasive coronary angiography (ICA). how should high-risk plaque be incorporated into treatment decisions? (7) how will CT-FFR influence other functional imaging test utilization, and what will be the effect on the practice of cardiology? (8) will a workstationbased CT-FFR be mandatory? Rapid progress to date suggests that CTA-based lesion-specific ischemia will be the gatekeeper to the cardiac catheterization laboratory and will transform the world of intervention.

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“…[92][93][94] CT perfusion may improve the overall diagnostic accuracy of cardiac CT, particularly in the interpretation of intermediate (30-70%) stenosis, 95 in the evaluation of stent patency, 96 and of diffuse atherosclerotic involvement with densely calcified plaques 97 ( Figure 5). …”

Section: Plaque Features Associated With Vulnerabilitymentioning

confidence: 99%

Chest pain: coronary CT in the ER

Maffei¹,

Seitun²,

Guaricci³

et al. 2016

BJR

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Cardiac CT has developed into a robust clinical tool during the past 15 years. Of the fields in which the potential of cardiac CT has raised more interest is chest pain in acute settings. In fact, the possibility to exclude with high reliability obstructive coronary artery disease (CAD) in patients at low-to-intermediate risk is of great interest both from the clinical standpoint and from the management standpoint. Several other modalities, with or without imaging, have been used during the past decades in the settings of new onset chest pain or in acute chest pain for both diagnostic and prognostic assessment of CAD. Each one has advantages and disadvantages. Most imaging modalities also focus on inducible ischaemia to guide referral to invasive coronary angiography. The advent of cardiac CT has introduced a new practice diagnostic paradigm, being the most accurate non-invasive method for identification and exclusion of CAD. Furthermore, the detection of subclinical CAD and plaque imaging offer the opportunity to improve risk stratification. Moreover, recent advances of the latest generation CT scanners allow combining both anatomical and functional imaging by stress myocardial perfusion. The role of cardiac CT in acute settings is already important and will become progressively more important in the coming years.

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A randomized, multicenter, multivendor study of myocardial perfusion imaging with regadenoson CT perfusion vs single photon emission CT

Abstract: This study establishes the noninferiority of regadenoson CTP to SPECT for detecting or excluding myocardial ischemia.

Cited by 72 publications

References 34 publications

Myocardial CT perfusion imaging for ischemia detection

Myocardial CT perfusion imaging for ischemia detection

Fractional Flow Reserve and Coronary Computed Tomographic Angiography

Chest pain: coronary CT in the ER

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