A randomized phase II study of a new tick-borne encephalitis vaccine using three different doses and two immunization regimens

An accelerated schedule for tick-borne encephalitis vaccine: the American Military experience in Bosnia.

“…6 Both Kunz and others 12 and Harabacz and others 6 noted a significant decrease in antibody titers from 9 to 10 months after the second dose on the conventional schedule.…”

“…This same vaccine, tested using an accelerated schedule of 0, 14, and 28 days among U.S. military personnel at USAMRIID, also demonstrated seroconversion rates of 25%, 95%, and 97% one week after each of 3 doses (Pittman PR, unpublished data). Harabacz and others 6 conducted trials of conventional and accelerated schedules using a competing, but antigenically similar vaccine (FSME-Vaccine Behring; Behringwerke AG, Marburg, Germany). When administered in the conventional schedule (0, 28, and 300 days) high seroconversion rates of 80%, 100%, and Ͼ90% after each of 3 doses were seen.…”

“…5 However, under the terms of an investigational new drug application, the vaccine was offered to soldiers on alert for deployment or already deployed to high risk areas of Bosnia under an accelerated schedule (0, 7, and 28 days). The timing of this schedule was based on previous accelerated schedule studies 6,7 and military operational requirements. For purposes of this report, and due to practical constraints and the wide range of intervals between doses, we considered an interval of 4-30 days between doses to be acceptable.…”

Vaccines and animal models for arboviral encephalitides

“…The highly successful TBE vaccination campaign in Austria resulted in a steady decline of morbidity and an almost complete elimination of disease from that country (Kunz, 2003). In addition to the Austrian vaccine, a second European TBE vaccine is registered in Germany (Klockmann et al, 1989;Harabacz et al, 1992).…”

Tick-Borne Encephalitis (TBE) Vaccination in Children: Advantage of the Rapid Immunization Schedule (i.e., days 0, 7, 21)

“…For the rapid immunization schedule, all three doses are administered within three weeks, with intervals of one and two weeks before the second and third dose, respectively, leading to seroconversion within three to four weeks. 14,15 The following study compares the immune response in children after vaccination according to three different primary immunization schedules, two of which are licensed for Encepur. Special focus is placed on the persistence of antibodies over the first 300 days after the start of primary immunization, and the impact of reducing the interval between the first and second dose from four to three weeks.…”