A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: Clinical and histologic outcomes

Serra‐Guillén, C.; Nagore, Eduardo; Hueso, L.; Traves, Víctor; Messeguer, F.; Sanmartín, O.; Llombart, B.; Requena, Celia; Botella‐Estrada, Rafael; Guillén, C.

doi:10.1016/j.jaad.2011.11.933

Cited by 75 publications

(65 citation statements)

References 21 publications

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“…45 A recent study compared photodynamic and imiquimod monotherapies against sequential application of photodynamic therapy followed by imiquimod. 46 The sequential regimen yielded higher clinical and histopathologic clearance rates than did either monotherapy. Further, local reactions during week 4 of the imiquimod treatment phase were significantly less intense in patients who had received previous photodynamic therapy than in patients treated with imiquimod only.…”

Section: Strategies To Reduce Recurrencementioning

confidence: 92%

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Current issues in the management of actinic keratosis

Ceilley

Jorizzo

2013

Journal of the American Academy of Dermatology

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Section: Strategies To Reduce Recurrencementioning

confidence: 92%

“…Further, local reactions during week 4 of the imiquimod treatment phase were significantly less intense in patients who had received previous photodynamic therapy than in patients treated with imiquimod only. 46 …”

Section: Strategies To Reduce Recurrencementioning

confidence: 99%

Current issues in the management of actinic keratosis

Ceilley

Jorizzo

2013

Journal of the American Academy of Dermatology

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“…It has been shown that TLR7 stimulation by imiquimod is a successful treatment for actinic keratosis (intradermal neoplasia), with 27% of patients exhibiting a complete clinical response. 4 It has also been shown that the application of imiquimod on invasive primary melanoma results in local regression of tumor size, which is associated with increased levels of CD4 C T and CD8 C T lymphocytes both in the skin and in lymph nodes. 5 …”

Section: Antitumor Effects Of Tlr7mentioning

confidence: 99%

Dual roles of TLR7 in the lung cancer microenvironment

2015

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“…20 PDT is effective for the treatment of multiple and diffuse AKs, and its cosmetic results are generally excellent. 43 However, it is not ideal for treating thicker or deeper AKs and is normally reserved for patients who exhibit an inadequate response to topical field therapy or cryosurgery. Patients may experience erythema, edema, and a burning sensation during the light therapy.…”

Section: Photodynamic Therapymentioning

confidence: 99%

How to treat actinic keratosis? An update

Costa

Scalvenzi

Ayala

et al. 2015

J Dermatol Case Rep

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Actinic keratosis (AKs) is one of the most common skin lesions leading to an increased risk of developing squamous cell carcinoma and other skin malignancies. The lesions principally arise as a result of excessive ultraviolet (UV) exposure. AKs may regress spontaneously, remain stable or evolve to invasive squamous cell carcinoma. The risk of squamous cell carcinoma is significantly increased patients with more than 5 AKs. The main mechanisms involved in the formation of AK are inflammation, mutagenesis, oxidative stress, impaired apoptosis, immunosuppression, disregulation of cell growth and proliferation, and tissue remodeling. Human papilloma virus has also been correlated with the formation of some AKs. As an individual ages, his skin is exposed to increasing cumulative amounts of UV light and other environmental insults. This is especially true for the head, neck and forearms. These insults do not target only the skin where individual lesions develop, but also the surrounding area. In this area undetectable preclinical AK lesions or dysplastic cells may be present. The whole affected area is known as the 'field'. Therefore, management is divided into lesion-directed and field-directed therapies. Currently, the therapies in use are lesion-directed cryotherapy and/or excision, and field-directed topical agents: 5-fluorouracil, diclofenac, photodynamic therapy, imiquimod, and ingenol mebutate. Combining lesion-and field-directed therapies showed good results and several novel therapies are under investigation. Treatment is variable and personalized, what makes a gold standard management algorithm difficult to design. This review aims to describe the rationale behind the available treatment options for AKs based on current understanding of pathophysiology and epidemiology. (J Dermatol Case Rep. 2015; 9(2): 29-35)

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A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: Clinical and histologic outcomes

Cited by 75 publications

References 21 publications

Current issues in the management of actinic keratosis

Current issues in the management of actinic keratosis

Dual roles of TLR7 in the lung cancer microenvironment

How to treat actinic keratosis? An update

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