A randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohns disease: Good safety profile but lack of efficacy

Holtmeier, Wolfgang; Zeuzem, Stefan; Preiß, J; Kruis, Wolfgang; Böhm, Stefan; Raedler, Andreas; Schmidt, Clint S.; Schnitker, J; Schwarz, JA; Zeitz, M.; Wf, Caspary

doi:10.1055/s-0030-1263688

Cited by 20 publications

(32 citation statements)

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“…In contrast to animal studies, a double-blind, randomized, placebocontrolled, multicenter trial in colitis patients showed higher remission in Boswellia serrata extract treated group than in the pacebo group (Madisch et al, 2007). However, a recent double-blind, placebo-controlled, randomized, parallel study in patients with Crohn's disease has shown no difference between the Boswellia treated group and control group in disease remission (Holtmeier et al, 2011).…”

Section: Animal Models Of Ibdmentioning

confidence: 82%

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Kota¹,

Teoh²,

Roufogalis³

2012

New Advances in the Basic and Clinical Gastroenterology

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Section: Animal Models Of Ibdmentioning

confidence: 82%

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Kota¹,

Teoh²,

Roufogalis³

2012

New Advances in the Basic and Clinical Gastroenterology

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“…Boswellia resins have been used in Ayurvedic medicine (shallaki or salai) [50] and in Europe (olibanum or frankincense) [51] . Boswellia extracts proved useful against collagenous colitis in one study but not in another ( Table 1 ) [52,94] . A random double-blind control study showed Boswellia extracts to be useful in CD but less efficacious than mesalamine [49] .…”

Section: Boswellia Serratamentioning

confidence: 96%

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions. However, the benefits of these supplements have not been established. The available 80 human trials were rated for levels of confidence and for benefits of the antioxidant supplements. For Crohn's disease, the supplements for which clear benefits occurred in at least 2 studies were allopurinol, Boswellia serrata (frankincense or shallaki), Artemesia species (wormwood), Tripterygium wilfordii (léi gōng téng), and omega-3 fatty acids. Similar beneficial supplements for ulcerative colitis were allopurinol, Matricaria chamomilla (chamomile), Curcuma longa (curcumin in turmeric), and omega-3 fatty acids. There was also a clear benefit for ulcerative colitis in 2 studies where a multiherbal Chinese medicine preparation and an Ayurvedic medicine preparation were used. For irritable bowel syndrome, there was only a marginal benefit of some of the antioxidant supplements. Thus, some antioxidant supplements may be beneficial at certain stages of specific diseases. This is consistent with the current concept that antioxidants act by inhibiting oxidative stress pathways in a tissue- and environment-specific manner and not by simply acting as scavengers.

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“…Of these, 24 studies (n=1,847) were about UC , while 5 studies (n=323) were on CD [49][50][51][52][53].…”

Section: Study Selectionmentioning

confidence: 99%

“…All except one study [50] investigated the induction of remission in active state. The CD study duration ranged from 1.5 to 12 months (median 2 months) ( Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Nine of the included studies (31.0%) described the appropriate method of random sequence generation such as a random number table [25,26,32] or computer-generated randomisation sequence [29,35,41,42,46,50] and only six studies (20.7%) adequately concealed group allocation [29,34,41,45,46,50]. For blinding of participants and personnel, 15 studies which tested herbal medicine as an adjunct to conventional medication against conventional medication alone were considered as having a high risk of bias [25, 27, 30, 32, 33, 36-40, 43, 44, 46, 49, 52] while all the placebo-controlled studies were given a low risk of bias except one study using a placebo not identical to verum [47].…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Adjunctive herbal medicine therapy for inflammatory bowel disease: A systematic review and meta-analysis

Kim

Lee

Zhang

et al. 2017

European Journal of Integrative Medicine

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A randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohns disease: Good safety profile but lack of efficacy

Cited by 20 publications

References 0 publications

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

Adjunctive herbal medicine therapy for inflammatory bowel disease: A systematic review and meta-analysis

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