A Randomized, Placebo-Controlled Study of the Efficacy of Cognitive Intervention on Elderly People and on Patient’s with Alzheimer’s Disease

Yanguas, José Javier; Buiza, Cristina; Etxeberría, Igone; Galdona, Nerea; González, Mari Feli; Urdaneta, Elena

doi:10.1007/11788713_111

Cited by 1 publication

(3 citation statements)

References 16 publications

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“…In the same study, patients with GDS scores of 3-4 (thus classifiable as minimal-mild AD) were trained with exercises targeting various cognitive functions and activities of daily living. Again, no improvements in cognitive abilities were registered [28]. A similar experimental attempt was made by Farina and colleagues [29][30], who piloted a protocol of CS targeting "residual cognitive functions" in a sample of mild-to-moderate AD.…”

Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 85%

“…-Insert Table 1 about here -A programme which aimed to stimulate those cognitive skills which were still spared was administered to a sample of moderate-severe AD patients (with a Global-Deterioration-Scale (GDS) score of 5-6) over a 2 year period. No improvement was detected [28]. In the same study, patients with GDS scores of 3-4 (thus classifiable as minimal-mild AD) were trained with exercises targeting various cognitive functions and activities of daily living.…”

Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 98%

“…No mention of concomitant pharmacological treatment was made in the studies by Yanguas et al [28], Farina et al. [29] and Kurz et al [31].…”

Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 99%

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Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Marco

Meneghello

Duzzi

et al. 2016

Brain Research Bulletin

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A cognitive-stimulation tool was created to regulate functional connectivity within the brain Default-Mode Network (DMN). Computerized exercises were designed based on the hypothesis that repeated task-dependent coactivation of multiple DMN regions would translate into regulation of resting-state network connectivity. Forty seniors (mean age: 65.90 years; SD: 8.53) were recruited and assigned either to an experimental group (n=21) who received one month of intensive cognitive stimulation, or to a control group (n=19) who maintained a regime of daily-life activities explicitly focused on social interactions. An MRI protocol and a battery of neuropsychological tests were administered at baseline and at the end of the study. Changes in the DMN (measured via functional connectivity of posterior-cingulate seeds), in brain volumes, and in cognitive performance were measured with mixed models assessing group-by-timepoint interactions. Moreover, regression models were run to test gray-matter correlates of the various stimulation tasks. Significant associations were found between task performance and gray-matter volume of multiple DMN core regions. Training-dependent up-regulation of functional connectivity was found in the posterior DMN component. This interaction was driven by a pattern of increased connectivity in the training group, while little or no up-regulation was seen in the control group. Minimal changes in brain volumes were found, but there was no change in cognitive performance. The training-dependent regulation of functional connectivity within the posterior DMN component suggests that this stimulation program might exert a beneficial impact in the prevention and treatment of early AD neurodegeneration, in which this neurofunctional pathway is progressively affected by the disease.

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Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 85%

Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 98%

See 1 more Smart Citation

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Marco

Meneghello

Duzzi

et al. 2016

Brain Research Bulletin

View full text Add to dashboard Cite

show abstract

A Randomized, Placebo-Controlled Study of the Efficacy of Cognitive Intervention on Elderly People and on Patient’s with Alzheimer’s Disease

Cited by 1 publication

References 16 publications

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

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