A Randomized, Placebo-Controlled Trial of Preoperative Oral Pregabalin for Postoperative Pain Relief After Minor Gynecological Surgery

Paech, Michael J.; Goy, Raymond; Chua, Sebastian M. H.; Scott, Karen; Christmas, Tracey; Doherty, Dorota

doi:10.1213/01.ane.0000286227.13306.d7

Cited by 135 publications

(96 citation statements)

References 15 publications

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“…15 They found that perioperative use of pregabalin in two doses of 150 mg 1 hour before surgery and then 12 hours after the first dose did not decrease the frequency or severity of shoulder pain as well as the severity of surgical pain after laparoscopic cholecystectomy. In another study conducted by Paech et al (2007) 22 comparing preoperative pregabalin (100 mg) in minor gynaecological surgeries did not find any significant difference in postoperative pain intensity in pregabalin group as compared to placebo. The finding in our study was in contrast to this study.…”

Section: Discussionmentioning

confidence: 88%

Preemptive Single-Dose Pregabalin in Modulation of Postoperative Pain and Opioid Requirement After Laparoscopic Cholecystectomy- A Randomized Clinical Study

Hazarika¹,

Talukdar²,

Bharali³

et al. 2018

jebmh

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BACKGROUNDWith the enormous advancement in the field of laparoscopic cholecystectomy, postoperative pain has substantially reduced as compared to open procedures. However, postoperative pain is still the most frequent complaint, which can hamper recovery, mandate inpatient admission and thereby increase the cost of such care. Preemptive analgesia attenuates sensitisation of pain before surgery so as to reduce postoperative hyperalgesia and allodynia. Pregabalin is a structural analog of γ-aminobutyric acid, which shows analgesic, anticonvulsant, and anxiolytic effects.The aim of the present study was to evaluate the effectiveness of preemptive oral pregabalin on postoperative pain and opioid consumption in patients undergoing laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 88%

Preemptive Single-Dose Pregabalin in Modulation of Postoperative Pain and Opioid Requirement After Laparoscopic Cholecystectomy- A Randomized Clinical Study

Hazarika¹,

Talukdar²,

Bharali³

et al. 2018

jebmh

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“…They also showed that PG consumption can reduce some opioid side effects, such as nausea and vomiting. On the contrary, in a recently published article, Paech et al 8 reported that a single preoperative dose of 100 mg PG was ineffective in reducing acute postoperative pain or improving recovery after minor gynecological surgery. Sundar et al 2 observed that a single oral dose of 150 mg PG given 1 hour prior to off-pump coronary artery bypass surgery did not show any effect on perioperative opioid consumption.…”

Section: Discussionmentioning

confidence: 95%

Comparison of Safety and Efficacy of ProSeal Laryngeal Mask Array vs Endotracheal Intubation for Gynecological Diagnostic Laparoscopy

Bhojraj¹,

Agaskar²,

Kapila³

et al. 2017

Journal of Research &Amp; Innovation in Anesthesia

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Aim and objective:We evaluated the effect of preoperative single-dose pregabalin (PG) on postoperative pain in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Materials and methods:In this double-blind study, 60 adult patients scheduled for elective on-pump CABG surgery were randomized into two groups of 30 each, viz., PG and placebo (PL). Patients received either oral PG 150 mg or a PL, 1 hour before surgery. All patients received general anesthesia. Postoperative pain relief was provided with intravenous tramadol 50 mg 8 hourly. Postoperative pain was assessed, both at rest and during coughing, with the 10-point verbal rating scale (VRS) at 6, 12, 18, and 24 hours after extubation. Time to extubation, pain scores, requirement of additional analgesics, and adverse effects were compared using chi-square test, unpaired t test, and Mann-Whitney U test. Results:The time to extubation was significantly prolonged in the PG group compared with PL (9.84 ± 1.88 vs 8.66 ± 2.12 hours, p = 0.027). The mean VRS scores at rest and during coughing were significantly lower in the PG group compared with PL (p < 0.05). However, the requirement of additional analgesics, such as paracetamol or tramadol was similar in the two groups. Conclusion:A single preoperative oral dose of PG 150 mg was effective in reducing postoperative pain in patients undergoing on-pump CABG compared with a PL.

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“…At variance with these observations, Paech et al [36] reported that a single preoperative dose of 100 mg pregabalin was ineffective in reducing acute postoperative pain or improving recovery after minor surgery involving only the uterus. This could possibly be attributed to a single small dose (100 mg) as against the recommended 150 mg/day.…”

Section: Discussionmentioning

confidence: 99%

The Analgesic Effect of Pregabalin, a Comparative Study With Morphine

A.Shabayek

A.Mustafa

Khorshid

et al. 2014

Zagazig University Medical Journal

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Objectives: this study was designed to assess and compare the effects of pregabalin and morphine on acute thermal pain and on nerve injury associated pain (chronic neuropathic pain). Methods: 72 male albino rats were divided into two major groups: group I (acute pain group) 30 rats divided into 5 equal subgroups (1)control, (2) pregabalin 30 mg/kg, (3)morphine 0.5 mg/kg, (4) pregabalin 60 mg/kg, (5)morphine 1mg/kg, and group II(chronic pain group) 42 rats were divided into 7 equal subgroups (1)sham operated, (2)control normal, (3) control postoperative, (4) pregabalin 30mg/kg, (5) morphine 0.5 mg/kg, (6) pregabalin 60 mg/kg, (7) morphine 1mg/kg. For acute pain the reaction times, which indicate the tolerability of the animals to acute thermal pain, was measured using analgesia meter. However chronic neuropathic pain was induced in experimental animals by unilateral ligation of the sciatic nerve in the thigh. Results: The result of the present study revealed that neither 30 nor 60 mg/kg pregabalin produced any significant effects on the tolerability of rats to acute thermal pain. On the other hand, pregabalin (30 and 60 mg/kg) markedly reversed allodynia and hyperalgesia in rats subjected to sciatic nerve ligation. The effect of pregabalin 30 mg/kg was noticed after 60 minutes and persist for 90 minutes but the higher dose (60 mg/kg) produced analgesic effect all over the experiment. On the other hand morphine 0.5 and 1 mg/kg significantly increased the tolerability of normal and sciatic nerve ligated rats to thermal nociception. The analgesic effect of morphine was more significant than that of pregabalin all over the experiments. Conclusion: in contradiction to morphine, pregabalin was not effective for treatment of acute pain. Both pregabalin and morphine produced significant analgesic effect in neuropathic pain. The effect of morphine was more significant than that of pregabalin.

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A Randomized, Placebo-Controlled Trial of Preoperative Oral Pregabalin for Postoperative Pain Relief After Minor Gynecological Surgery

Abstract: A single preoperative dose of 100 mg pregabalin does not reduce acute pain or improve recovery after minor surgery involving only the uterus.

Cited by 135 publications

References 15 publications

Preemptive Single-Dose Pregabalin in Modulation of Postoperative Pain and Opioid Requirement After Laparoscopic Cholecystectomy- A Randomized Clinical Study

Preemptive Single-Dose Pregabalin in Modulation of Postoperative Pain and Opioid Requirement After Laparoscopic Cholecystectomy- A Randomized Clinical Study

Comparison of Safety and Efficacy of ProSeal Laryngeal Mask Array vs Endotracheal Intubation for Gynecological Diagnostic Laparoscopy

The Analgesic Effect of Pregabalin, a Comparative Study With Morphine

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