A randomized placebo‐controlled trial on the effects of Menthacarin, a proprietary peppermint‐ and caraway‐oil‐preparation, on symptoms and quality of life in patients with functional dyspepsia

Rich, Graeme; Shah, Ayesha; Koloski, Natasha A.; Funk, Petra; Stracke, B; Köhler, Stephan; Holtmann, Gerald

doi:10.1111/nmo.13132

Cited by 115 publications

(70 citation statements)

References 45 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The studies published between 1991 and 2019 were included. Patients had FD, [15][16][17][18][19][20][21][22]13,14,[23][24][25][26][27][28][29][30][31][32] and constipation [56][57][58][59][60][61][62] in 19, 23 and 7 trials respectively. More than 33 different kinds of herbal formulae were tested in the included trials.…”

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aims The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta‐analysis was conducted to determine their effectiveness for FGIDs. Methods We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double‐blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included. Results In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR = 1.67, 95% CI 1.48–1.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non‐inferior (RR = 1.10, 95% CI 1.03–1.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR = 1.50, 95% CI 1.32–1.69), IBS (RR = 1.62, 95% CI 1.32–1.97) and FC (RR = 3.83, 95% CI 2.26–6.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs. Conclusions Our findings provide a positive signal for HMs as a potentially well‐tolerated and effective treatment for FGIDs, deserving further examination in high‐quality trials.

show abstract

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…May et al reported a strong improvement in 66% of the patients after peppermint/caraway oil treatment compared to 20.9% after placebo . Furthermore, Rich et al reported an improvement in FD symptoms of more than 10% in 88% of the patients after peppermint/caraway oil treatment compared to 55.4% after placebo . Lastly, Chey et al confirmed the superiority of peppermint/caraway oil treatment over placebo, showing symptom improvement in 78% of PDS patients and 72% of EPS patients compared to 50% and 40% in the control groups, respectively .…”

Section: Current Treatment Options For Functional Dyspepsiamentioning

confidence: 97%

Review article: treatment options for functional dyspepsia

Masuy

Oudenhove

Tack

2019

Aliment Pharmacol Ther

100

124

View full text Add to dashboard Cite

Background: Functional dyspepsia, consisting of epigastric pain syndrome and postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are available and conflicting results in terms of efficacy have been reported. Consequently, nonpharmacological treatment options are increasingly being explored for functional dyspepsia. Aim: To provide an overview of current pharmacological and nonpharmacological treatment options for functional dyspepsia. Methods: A literature search was conducted on Pubmed and other sources to identify relevant studies.Results: Acid suppressive therapy reduced symptoms in 30%-70% of the patients, with higher benefit in epigastric pain syndrome and superior effectiveness for proton pump inhibitors compared to H 2 -antagonists. Prokinetic agents, primarily used to treat postprandial distress syndrome, showed variable efficiency: 59%-81% responder rate for dopamine receptor antagonists, 32%-91% for serotonin-4-receptor agonists and 31%-80% for muscarinic receptor antagonists. H Pylori eradication, recommended in infected patients, was effective in 24%-82%. Refractory symptoms are addressed with neuromodulators. However, their efficacy in functional dyspepsia remains incompletely elucidated, available data showing symptom reduction in 27%-71% of the patients. Regarding herbal agents, peppermint oil reduced symptoms in 66%-91%, rikkunshito in 29%-34% and iberogast in 20%-95%. Lastly, acupuncture, cognitive behavioural therapy and hypnotherapy may help to provide symptom control, but research on their efficacy remains sparse.Conclusions: None of the available therapies is effective in the majority of patients without being associated with major side effects. Developing new treatment options is challenging due to the heterogeneity of functional dyspepsia, the lack of readily identified target mechanisms and the poor association between pathophysiological disturbances and symptoms.

show abstract

“…Für dieses Produkt liegt eine Reihe von Studien vor, in denen sich u. a. im Vergleich zu dem früher üblichen Cisaprid eine vergleichbare [27] und vs. Placebo eine sehr gute [29], [30], [34] Wirksamkeit zeigte, sogar auch bei der Langzeitanwendung von bis zu 12 Monaten [17], [43] bei nicht säurebedingter funktioneller Dyspepsie, in einer Studie auch bei chronisch-entzündlichen Darmerkrankungen [4]. Eine jüngere Analyse der Daten aus 3 Studien (Metaanalyse von Subgruppen) ergab zudem eine Wirkung (Zielgröße: Schmerzempfinden) bei Dyspepsie-Patienten mit typischen Symptomen eines Reizdarms [28].…”

Section: Wirkungenunclassified

Gastrointestinale Wirkungen von Kümmelöl, Carvi aetheroleum

Wegener¹

2020

Z Phytother

View full text Add to dashboard Cite

ZusammenfassungDas ätherische Kümmelöl aus Carum carvi L., Carvi aetheroleum, bestehend überwiegend aus den Terpenen (S)-(+)-Carvon und (R)-(+)-Limonen, wird bei Verdauungsbeschwerden, einhergehend mit Blähungen und Flatulenz, oder sogar bei flatulenzbedingten Koliken angewandt. Überwiegend aktuelle experimentelle Daten geben Hinweise oder bekräftigen die bereits früher postulierten Wirkungen. Zu nennen sind vor allem karminative (entblähende) Wirkungen im Gastrointestinum durch spasmolytische bzw. entkrampfende Eigenschaften, eine mögliche Hemmung der intestinalen Gärungsprozesse durch antimikrobielle (auf pathogene Keime beschränkt) Wirkungen, eine Volumenreduktion durch Hemmung der Schaumbildung von Magen- und Darmsaft und damit eine mögliche Reduktion blähungsbedingter Schmerzen sowie direkte antinozizeptive Eigenschaften. Ergebnisse aus klinischen Untersuchungen und Studien können die Wirkungen z. T. für das Kümmelöl alleine, besser für eine langjährig bewährte Kombination zusammen mit Pfefferminzöl, z. B. in der Anwendung bei typischen Symptomen funktioneller Verdauungsstörungen bestätigen.

show abstract

A randomized placebo‐controlled trial on the effects of Menthacarin, a proprietary peppermint‐ and caraway‐oil‐preparation, on symptoms and quality of life in patients with functional dyspepsia

Abstract: Menthacarin is an effective therapy for the relief of pain and discomfort and improvement of disease-specific QoL in patients with FD and significantly improves symptoms consistent with EPS and PDS.

Cited by 115 publications

References 45 publications

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Review article: treatment options for functional dyspepsia

Gastrointestinale Wirkungen von Kümmelöl, Carvi aetheroleum

Contact Info

Product

Resources

About