A randomized prospective trial comparing gonadotropin-releasing hormone (GnRH) antagonist/recombinant follicle-stimulating hormone (rFSH) versus GnRH-agonist/rFSH in women pretreated with oral contraceptives before in vitro fertilization

Barmat, Larry I.; Chantilis, S.J.; Hurst, Bradley S.; Dickey, Richard P.

doi:10.1016/j.fertnstert.2004.06.076

Cited by 98 publications

(56 citation statements)

References 26 publications

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“…This flexibility is beneficial for both the patients' convenience in controlling their time of stimulation and for the IVF units for controlling their workload. To overcome this limitation in the GnRH antagonist protocol, patients can be offered the use of pretreatment with oral contraceptive pills (OCP) [4][5][6][7]. Moreover, a previous study has shown that OCP pretreatment before GnRH antagonist led to higher numbers of oocytes retrieved compared to the standard GnRH antagonist protocol [8].…”

Section: Introductionmentioning

confidence: 99%

The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome

Pinkas

Sapir

Avrech

et al. 2008

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome

Pinkas

Sapir

Avrech

et al. 2008

J Assist Reprod Genet

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“…In women pretreated with OCP, a randomized prospective trial has shown that 78 % of retrievals could be performed Monday through Friday for GnRH antagonist cycle [10]. But use of OCP prior to stimulation in antagonist cycle is associated with an increased gonadotropin consumption and increased duration of stimulation and with a trend toward a reduction in ongoing pregnancy rate [11].…”

Section: Programming Of Antagonist Cyclesmentioning

confidence: 99%

Precycle Estradiol in Synchronization and Scheduling of Antagonist Cycles

Saple¹,

Agrawal²,

Kawar³

2016

J Obstet Gynecol India

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Antagonist cycles have an inherent issue of lack of flexibility. As a result where batching of cycles is desired, it is not the preferred protocol in ART cycles. There is also the limitation of ovarian response in antagonist cycle due to the size heterogenesities of antral follicles at the start of stimulation. Among the different options available, use of estrogen in the luteal phase of the preceding cycle has definitely shown benefits with regard to better control of cycle as well as synchronization of follicles available for stimulation. The article gives a detailed analysis of the different options available for timing the egg collection in antagonist cycles, the advantages and drawbacks, and the method of use of estrogen. Whereas in the majority of the trials where estrogen pretreatment was used, the goal of scheduling of egg collection was definitely achieved, increased duration and dose of gonadotropin stimulation were required. There was definite advantage of higher oocyte yield in these cycles. The possibility of premature LH rise later during stimulation and subsequent poor implantation in these cycles has to be further evaluated. Nevertheless, batching of patient friendly antagonist cycles can be effectively possible by use of precycle estrogen treatment.

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“…Cycle scheduling allows fertility clinics to better distribute the number of oocyte retrievals in a week, resulting in a more balanced workload, improved efficiency, and potentially a decrease in the occurrence of errors. These advantages can be particularly important within the embryology laboratory [1,8]. Scheduling is also more convenient for the patient, as it provides flexibility in timing the start of stimulation [1,8].…”

Section: Introductionmentioning

confidence: 99%

“…These advantages can be particularly important within the embryology laboratory [1,8]. Scheduling is also more convenient for the patient, as it provides flexibility in timing the start of stimulation [1,8].…”

Section: Introductionmentioning

confidence: 99%

Profound Pituitary Suppression Following Oral Contraceptive Pretreatment in Gonadotropin-releasing Hormone Antagonist Cycles Does Not Impact Outcome: A Retrospective Cohort Study

Vela¹,

Ruman²,

Luna³

et al. 2017

J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol

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Background: This retrospective study evaluated the effect of profound pituitary suppression with oral contraceptive pill (OCP) pretreatment in gonadotropin-releasing hormone (GnRH) antagonist cycles stimulated with recombinant follicle stimulating hormone plus highly purified human menopausal gonadotropin. Results:In the LH ≤1.5 and >1.5 mIU/mL groups, respectively, the mean number of stimulation days was 10.9 and 9.5 days (P<0.0001); mean total gonadotropin use was 4,328 and 3,543 IU (P<0.0001). Oocyte retrieval was greater in the LH ≤1.5 versus >1.5 mIU/mL group (17.7 vs. 14.9 oocytes; P=0.02). Pregnancy outcomes were similar between groups. Longer OCP duration correlated with lower day 1 LH levels (r=-0.161, P=0.007). Greater LH suppression correlated with increased total gonadotropin dose (r=-0.227, P<0.001) and days of stimulation (r=-0.445, P<0.001). Conclusion:Women with profound LH suppression following OCP pretreatment demonstrated comparable prognosis compared with women without profound LH suppression, despite requiring longer stimulations and a higher total gonadotropin dose.

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A randomized prospective trial comparing gonadotropin-releasing hormone (GnRH) antagonist/recombinant follicle-stimulating hormone (rFSH) versus GnRH-agonist/rFSH in women pretreated with oral contraceptives before in vitro fertilization

Cited by 98 publications

References 26 publications

The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome

The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome

Precycle Estradiol in Synchronization and Scheduling of Antagonist Cycles

Profound Pituitary Suppression Following Oral Contraceptive Pretreatment in Gonadotropin-releasing Hormone Antagonist Cycles Does Not Impact Outcome: A Retrospective Cohort Study

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