A randomized, single-blind, active controlled study to compare the efficacy of salicylic acid and mandelic acid chemical peel in the treatment of mild to moderately severe acne vulgaris

Jartarkar, Shishira R.; Gangadhar, Bugude; Mallikarjun, M; Manjunath, P

doi:10.4103/2542-551x.196946

Cited by 9 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peeling using a solution containing 30% salicylic acid is more effective than peeling with a solution containing 45% mandelic acid for treating non-inflammatory skin lesions 14 . The results of this study align with those of Jartarkar et al, who also found that salicylic acid peeling was more efficacious than mandelic acid peeling in the treatment of non-inflammatory acne, with a statistically significant difference 20 .…”

Section: Trichloroacetic Acid 25%supporting

confidence: 90%

The Effectiveness Of Salicylic acid Therapy In Mild and Moderate Acne Vulgaris

Nafila,

Nursanto,

Sintowati

et al. 2024

magnamed

View full text Add to dashboard Cite

Background: Acne vulgaris is a chronic inflammatory disease of polysebaceous follicles characterized by lesions that include blackheads, papules, pustules, nodules, and cysts. The prevalence of acne vulgaris is most significant among adolescents aged 15 to 18. In mild and moderate acne vulgaris, topical treatment enhances skin conditions. It is believed that the ability of salicylic acid to reach the stratum corneum, which exfoliates due to its comedolytic properties, aids in the healing of acne vulgaris.Objective: Evaluate the efficacy of salicylic acid as a treatment for mild and moderate acne vulgaris.Methods: This study's design involved a literature search using the terms acne vulgaris and salicylic acid in Google Scholar, PubMed, and Science Direct.Results: The investigation found 108 articles were discovered and excluded based on the restriction criteria; 8 articles were reviewed. Salicylic acid substantially improved mild and moderate acne, according to all studies. Improvement was measured based on the lesion's severity, the lesion type, and Goodman's qualitative global scarring grading system. There is an improvement in inflammatory, non-inflammatory, and hyperpigmented lesions.Conclusion: Salicylic acid is clinically beneficial for mild to moderate acne vulgaris.

show abstract

Section: Trichloroacetic Acid 25%supporting

confidence: 90%

The Effectiveness Of Salicylic acid Therapy In Mild and Moderate Acne Vulgaris

Nafila,

Nursanto,

Sintowati

et al. 2024

magnamed

View full text Add to dashboard Cite

show abstract

“…It also has anti‐inflammatory and strong comedolytic effects . Its effectiveness has been proven in the treatment of both inflammatory and noninflammatory acnes . In addition, it is effective against postinflammatory hyperpigmentation (PIH) caused by acne via its desquamating effect .…”

Section: Discussionmentioning

confidence: 99%

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Wanitphakdeedecha

Tavechodperathum

Tantrapornpong

et al. 2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background: Depending on disease severity, standard acne treatments can vary from topical to systemic therapy. However, poor compliance caused by adverse events and antibiotic resistance is a major cause of treatment failure. Aims: To determine the effectiveness of photodynamic therapy (PDT) with intense pulsed light (IPL) in the treatment of acne when combined with a cream containing licochalcone A, L-carnitine and decanediol (so-called, 'active formulation') versus PDT alone. Patients/Methods: Twenty-nine volunteers, aged 21-39 years (26 women and 3 men, mean age 29.41 ± 5.24 years), with mild to severe facial acne, were enrolled. Each subject's face sides were randomized in a split-face manner to either receive PDT (IPL with a 400-720 nm cutoff filter, at 4 sessions with two-week intervals) combined with the active formulation cream twice daily for 10 weeks on one face side; or PDT and the vehicle cream on the other side, with the same treatment protocol. Reduction in acne quantity, melanin index and erythema index were assessed 2 weeks after the second treatment (day 28), 1 week after the fourth treatment (day 49), and 1 month after the fourth treatment (day 70). Results: Compared to baseline, patients in the active formulation group demonstrated a faster onset of reduction in the number of lesions at 2 weeks after the second treatment (p=0.010 for inflammatory acne and p=0.001 for non-inflammatory acne). A significantly greater reduction in lesion count was observed in the active formulation group compared with the vehicle group at all timepoints of evaluation for noninflammatory acne (day 28, day 49, and day 70; p=0.003, 0.005 and 0.002 respectively), and at 1 month after the fourth treatment for inflammatory acne (p=0.036). Compared to the vehicle group, the melanin index of the active formulation group decreased significantly at 1 month after the fourth treatment (p=0.015).

show abstract

“…Several authors have studied the effectiveness of different single peeling agents in the treatment of acne vulgaris, and they all reported significant improvement in the acne lesions . On the other hand, only one study by Garg et al had evaluated the use of combination peels vs single peel in the treatment of acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%