A randomized, single‐blind and crossover study of an amino acid‐based milk formula in treating young children with atopic dermatitis

Leung, Ting Fan; Chiu, Kwong Yuen; Cheung, LK; Lam, Christopher Wai‐Kei; Wong, Eric; Wan, Helene; Hon, Ellis K.L.

doi:10.1111/j.1399-3038.2004.00197.x

Cited by 30 publications

(12 citation statements)

References 19 publications

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“…Although not recommended as a direct substitute for cow's milk in sensitized individuals, soy sensitization is relatively uncommon. Our published clinical trial also showed that an amino acid‐based milk formula was not useful in treating AD in young children (15). In the previous study, (6) disease severity did not bear any relationship with the prevalence of sensitization to common food.…”

Section: Discussionmentioning

confidence: 94%

Patterns of food and aeroallergen sensitization in childhood eczema

et al. 2008

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Milk sensitization is far less prevalent than egg white, and the prevalence does not change beyond infancy. There is no significant change in prevalence in many of the common food allergens beyond infancy. Many infants with AD develop eczema before they show atopy to the common food and aeroallergens. The SPT information is useful in reassuring parents of the unlikelihood of severe Type 1 immediate IgE reaction to some of the common food and aeroallergens, so that empirical and multiple food avoidance/restriction can be avoided.

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Section: Discussionmentioning

confidence: 94%

Patterns of food and aeroallergen sensitization in childhood eczema

et al. 2008

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“…Two studies blinded participants and outcome assessors (24, 25). Three studies blinded the outcome assessor only (22, 26, 27). In three studies blinding was unclear (19–21).…”

Section: Resultsmentioning

confidence: 99%

“…Elemental diets. Two Elemental diet studies, one cross‐over study (26) and one parallel study (23). The Munkvad study found no significant difference between the two groups for the combined outcome of pruritus, sleeplessness and antihistamine usage (RR 1.69, 95% CI 0.2 to 13.93).…”

mentioning

confidence: 99%

Dietary exclusions for improving established atopic eczema in adults and children: systematic review

Bath‐Hextall

Delamere

Williams

2009

Allergy

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Atopic eczema is the most common inflammatory skin disease of childhood in developed countries. We performed a systematic review of randomized controlled trials to assess the effects of dietary exclusions for the treatment of established atopic eczema. Nine trials (421 participants) were included, most of which were poorly reported. Six were studies of egg and milk exclusion (n = 288), one was a study of few foods (n = 85) and two were studies of an elemental diet (n = 48). There appears to be no benefit of an egg‐ and milk‐free diet in unselected participants with atopic eczema. There is also no evidence of benefit in the use of an elemental or few‐foods diet in unselected cases of atopic eczema. There may be some benefit in using an egg‐free diet in infants with suspected egg allergy who have positive specific IgE to eggs – one study found 51% of the children had a significant improvement in body surface area with the exclusion diet as compared with normal diet (95% CI 1.07–2.11) and change in surface area and severity score was significantly improved in the exclusion diet as compared with the normal diet at the end of 6 weeks (MD 5.50, 95% CI 0.19–10.81) and end of treatment (MD 6.10, 95% CI 0.06–12.14). Despite their frequent use, we find little good quality evidence to support the use of exclusion diets in atopic eczema.

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“…Evidence level: B Comments: A systematic review 161 containing 9 RCTs was reported in the Cochrane Collaboration 2008. [332][333][334][335][336][337][338][339][340] Overall, the quality of those RCTs was poor, thus, their evidence level was determined to be low.…”

Section: Cq15 Is the Allergen Elimination Diet Effective For The Trementioning

confidence: 99%

Clinical practice guidelines for the management of atopic dermatitis 2018

Katoh

Ohya

Ikeda

et al. 2019

The Journal of Dermatology

103

243

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Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. The current strategies to treat AD in Japan from the perspective of evidence‐based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity‐related patient outcomes with respect to several important points requiring decision‐making in clinical practice.

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A randomized, single‐blind and crossover study of an amino acid‐based milk formula in treating young children with atopic dermatitis

Cited by 30 publications

References 19 publications

Patterns of food and aeroallergen sensitization in childhood eczema

Patterns of food and aeroallergen sensitization in childhood eczema

Dietary exclusions for improving established atopic eczema in adults and children: systematic review

Clinical practice guidelines for the management of atopic dermatitis 2018

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