A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg

Abstract

Liver biochemistry improved in PBC patients receiving UDCA 20 mg/kg/day compared to a dose of 10 mg/kg/day. Both doses were equally well tolerated. These results indicate that UDCA 10 mg/kg/ day is a suboptimal dose for treating PBC.

Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

“…Both in patients with PBC and in healthy subjects, daily intake of a scheduled standard dose of 15 mg/kg of UDCA [1,2] resulted in biliary enrichment of UDCA to about 40%, which is regarded as surrogate for therapeutic action [21]. Mild cholestatic disease did not affect biliary bile acid species in general, but their conjugation pattern in that taurine conjugation of the major hydrophobic bile acid, CDCA, was much more prominent in PBC.…”

Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: Effects on primary bile acids in babies and mothers

“…The high dosage was chosen because of the intestine's scarce capacity to absorb UDCA, because absorption is dose dependent, 8 and, finally, because in primary biliary cirrhosis patients high doses of UDCA are correlated with a better biochemical outcome. 9 Ten patients who did not give their consent to receive UDCA were treated with a low-fat diet and bed rest. Antihistamines were used for the management of intractable pruritus, on request.…”

The long-term effect of ursodeoxycholic acid on laboratory liver parameters in biochemically non-advanced primary biliary cirrhosis

“…Exclusion criteria were age >75, pregnancy, evidence of extrahepatic biliary disease, autoimmune-overlap syndrome or use of immunosuppressive drugs, concomitant disorders limiting life expectancy and decompensated PBC, defined as Child-Pugh class B or C cirrhosis. Following inclusion, patients started with UDCA therapy 13-15 mg/kg/day [10]. Laboratory data (serum levels of bilirubin, ALP, AST, ALT, albumin and IgM were collected at 3-month intervals in the first year and at yearly intervals thereafter.…”