A randomized trial of adding fluoxetine to a naltrexone treatment programme for heroin addicts

Landabaso, M.A.; Iraurgi, Ioseba; Jiménez-Lerma, Juan Manuel; Sanz, Juan José Alió; Corres, B. Fernadez De; Araluce, K.; Calle, R.; Gutiérrez-Fraile, Miguel

doi:10.1046/j.1360-0443.1998.9357399.x

Cited by 35 publications

(16 citation statements)

References 4 publications

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“…The retention rates reported at 6 months ranged between 33% and 74% [23,24,35,37,38,41], with the highest figures reported in Washton et al's [35] study of 'highly-motivated' business executives and physicians. If we exclude the studies by Hulse & Basso [23,24], Landabaso [41] and Washton et al [35], as they are not representative of the general treatment population and standard naltrexone treatment, retention rates reported at 6 months range from 33% to 40%.…”

Section: Introductionmentioning

confidence: 63%

“…If we exclude the studies by Hulse & Basso [23,24], Landabaso [41] and Washton et al [35], as they are not representative of the general treatment population and standard naltrexone treatment, retention rates reported at 6 months range from 33% to 40%. The only study to report 12-month retention rates was the Australian study by Foy et al [22], with 34% of participants remaining in treatment after 12 months.…”

Section: Introductionmentioning

confidence: 96%

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Naltrexone maintenance for heroin dependence: uptake, attrition and retention

Tucker

Ritter

Maher

et al. 2004

Drug and Alcohol Review

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With naltrexone registered only recently in Australia in 1999, it is important to examine the rate of uptake of naltrexone treatment, early attrition and retention rates during treatment, in order to inform the way naltrexone is used in Australian practice. Of 317 people screened for the study, 97 participants were recruited post-withdrawal from opiates and were inducted to naltrexone after a period of at least 5 days of abstinence. While in treatment, participants received a 50-mg dose of naltrexone daily, with daily dispensing for the first 7 days, and weekly dispensing for the following 11 weeks. For the naltrexone-treated sample as a whole, the rate of uptake of naltrexone treatment was 30%, with 30% retained in treatment for the entire 12-week program. Attrition from treatment was found to be steady throughout the 12 weeks. The authors conclude that further research is required to improve withdrawal and naltrexone induction techniques and to improve medication compliance and treatment retention.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 96%

Naltrexone maintenance for heroin dependence: uptake, attrition and retention

Tucker

Ritter

Maher

et al. 2004

Drug and Alcohol Review

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“…64 The former trial involved only 13 patients and thus had little power to demonstrate any clinically relevant effects. The latter involved 112 patients, but unfortunately there was neither blinding nor placebo and thus there are some threats to its validity that need to be borne in mind when considering the results.…”

Section: Pharmaceutical Agentsmentioning

confidence: 99%

Oral naltrexone as a treatment for relapse prevention in formerly opioid-dependent drug users: a systematic review and economic evaluation

Adi¹,

Juarez-Garcia²,

Wang³

et al. 2007

Health Technol Assess

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“…Landabaso and associates 16 conducted a randomized trial of 112 heroin addicts in Spain to test whether fluoxetine would enhance retention in a naltrexone treatment program. The investigators found that the combination of fluoxetine and naltrexone (n = 56) produced significantly greater retention than in patients given only naltrexone (n = 56).…”

Section: Combinations With Other Medicationsmentioning

confidence: 99%