A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia

Li, Su-na; Qian, Li-qi; Ma, Jianying; Xia, Zhongyuan; Liu, Guiyang; Gao, Fei; Yang, Ding-you; Yu, Yang; Zheng, Bin-li; Zhang, Jinghong

doi:10.1007/s11655-013-1321-6

Cited by 3 publications

(2 citation statements)

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“…LRK, a TCM formula, has been clinically used for the treatment of HMG for several years. The First Affiliated Hospital of the General Hospital of PLA conducted clinical trials and demonstrated that LRK could inhibit HMG ( Li et al, 2013 ). Previous study showed high effective rate (88.0%) in the treatment of HMG.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms

et al. 2018

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Li-Ru-Kang (LRK), a formula of eight traditional Chinese medicines (TCM), has been used to treat hyperplasia of mammary gland (HMG) in TCM clinics. However, how LRK works in HMG patients is unclear. To explore the possible mechanisms of LRK against HMG, the network pharmacology was used to screen the potential targets and possible pathways that involved in LRK treated HMG. Rat HMG model induced by estrogen and progesterone was used to further verify the effects of the key molecules of LRK selected from the enriched pathways on HMG. Nipple heights and diameters were measured and uterus index was calculated. The histopathological changes of mammary gland tissue were detected by hematoxylin-eosin (H&E) staining. Western blot was used to detect the phosphorylation of ERK, JNK, and P38. And immunohistochemistry staining was performed to evaluate the levels of estrogen receptor α (ERα), progesterone receptor (PR), nuclear factor-(NF-)κB (p65), interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), cyclooxygenases 2 (COX-2), inducible nitric oxide synthase (iNOS), 8-hydroxy-2′deoxyguanosine (8-OHdG), and nitrotyrosine (NT). Our results indicate that LRK treatment rescues significantly nipples height and diameter, decreases uterus index and ameliorates HMG. LRK treatment also markedly attenuates the over-expression of IL-1β, TNF-α, COX-2, and iNOS, and suppressed the formation of 8-OHdG and NT. Furthermore, LRK treatment significantly inhibits the phosphorylation of JNK, ERK, and p38 and expression of NF-κB (p65), interestingly, LRK treatment has no effect on the expression of ERα and PR. Our data suggest that the LRK treatment protects the mammary glands from the damage of oxidative stress and inflammation induced by estrogen and progesterone, via suppresses of MAPK/NF-κB signaling pathways without affecting on the expression of ERα and PR.

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Section: Discussionmentioning

confidence: 99%

“…LRK has an overall regulatory effect on HMG. The randomized trials of LRK showed that LRK had favorable effect in the treatment of HMG ( Qian et al, 2007 ; Li et al, 2013 ). Studies showed that LRK could improve the histological lesions in mammary gland, uterus and ovaries ( Qian et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms

et al. 2018

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Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Liu

Wang

et al. 2022

Molecular Nutrition Food Res

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Scope: Royal jelly (RJ) has a wide range of biological functions, its effect on hyperplasia of the mammary gland (HMG) in mammals is unclear. This study aims to investigate the effect of RJ on HMG and the dose-response relationship of RJ in the treatment of HMG. Methods and Results: HMG rats are induced by intramuscular injection of estrogen (E2) and progesterone, and are treated with different doses of RJ (100, 200, 400, and 800 mg kg -1 d -1 ). As a result, RJ improves the expansion of acinar and breast tissue ducts, particularly at 100 and 800 mg kg -1 d -1 . These two doses also inhibit serum E2 and prolactin (PRL) secretion and increase serum progesterone secretion and the expression of estrogen receptor (ER)-𝜷 in the breast tissue. In addition, 800 mg kg -1 d -1 decrease and increase the mRNA expression of, respectively, hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary GnRH receptors (GnRH-R). The lowest dosage (100 mg kg -1 d -1 ) increases GnRH-R mRNA expression as well. However, the effects of 200 and 400 mg kg -1 d -1 RJ on the reproductive parameters of HMG are not significant, implying a dose-dependent effect. Conclusion: RJ regulates endocrine dyscrasia in HMG rats and improves the breast tissue structure, indicating its potential in the prevention and treatment on HMG.

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Network pharmacology exploration reveals the bioactive compounds and molecular mechanisms of Li-Ru-Kang against hyperplasia of mammary gland

et al. 2019

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A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia

Abstract: Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia. The mechanism might be related to the regulation of sex hormones.

Cited by 3 publications

References 2 publications

Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms

Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms

Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Network pharmacology exploration reveals the bioactive compounds and molecular mechanisms of Li-Ru-Kang against hyperplasia of mammary gland

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