A randomized trial of Citanest with Octapressin for relief of pain associated with laser vaporization of the cervix

Lee, E. T. C.; Ozumba, E. N.; Bevan, J. R.

doi:10.1111/j.1471-0528.1986.tb08017.x

Cited by 23 publications

(18 citation statements)

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“…Prilocaine with felypressin causes statistically significant fewer side effects like feeling faint and shaking; however, the blood loss is greater than that occurring with lignocaine and adrenaline [6]. There is evidence to support local anaesthetic use to reduce postoperative analgesic requirements in large loop excision of transformation zone and episiotomies [7,8] There is some evidence to suggest the same in pelvic floor surgery, but the data are not very robust [9].…”

Section: Discussionmentioning

confidence: 94%

Survey of use of local infiltration and vasoconstrictors in vaginal surgery

et al. 2007

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To survey the practice and reasons of use of local infiltration in prolapse and continence surgery in UK, an electronic survey of gynaecologists with special interest in urogynaecology, urogynaecologists, urologists and allied professionals who were on the email list of the International Continence Society (ICS), UK was carried out in April-July 2006. Out of the 238 questionnaires that were sent, 112 failed mail delivery and 57 questionnaires were returned, giving a response rate of 50.1%. Of the respondents, 40/46 (86.9%) used local infiltration for vaginal hysterectomy and vaginal repairs, whilst 43/46 (93.4%) used it for TVT. Of the respondents, all of 18 who performed vaginal mesh procedures used local infiltration. While 90% of respondents felt it helped reduce blood loss, only 46% were convinced that it helped reduce visceral injury. The survey reflects that the majority use local infiltration for gynaecological surgery: however, there is wide variation in the type and strengths of agents used.

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Section: Discussionmentioning

confidence: 94%

Survey of use of local infiltration and vasoconstrictors in vaginal surgery

et al. 2007

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“…Of three trials (Dane 2008;Gimpleson 1999;Howells 2000) that reported data on stage, 80 women had CIN 1, 53 had CIN 2, 114 women had CIN 2-3, 60 had CIN 3 with a further 12 having normal histology and seven having missing data or having a different histology. Classification was not reported in nine trials (Doyle 1992;Gilbert 1989;; Grundsell 1984(b); Lee 1986;Lipscomb 2006;Lundvall 1984;Rybo 1972;Sabol 1971).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Included studies-The 12 included trials randomised a total of 1602 women of whom 1512 were assessed at the end of the trials. Of these trials, four were from the UK (Doyle 1992;Gilbert 1989;Howells 2000;Lee 1986), two from the USA (Gimpleson1999; Lipscomb 2006), one from Denmark (Lundvall 1984), three from Sweden ; Grundsell 1984(b); Rybo 1972) and one from Turkey (Dane 2008).The largest trial recruited 230 women (Lundvall 1984), with the smallest recruiting 48 (Gimpleson 1999) participants.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Of these trials, the majority are single centre (Dane 2008;Doyle 1992;Gilbert 1989;Gimpleson 1999;; Howells 2000;Lee 1986;Lipscomb 2006;Rybo 1972;Sabol 1971), with only one trial conducted at two or more centres (Lundvall 1984). Of three trials (Dane 2008;Gimpleson 1999;Howells 2000) that reported data on stage, 80 women had CIN 1, 53 had CIN 2, 114 women had CIN 2-3, 60 had CIN 3 with a further 12 having normal histology and seven having missing data or having a different histology.…”

Section: Description Of Studiesmentioning

confidence: 99%

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Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia

Martin-Hirsch¹,

Kitchener²

1999

Cochrane Database of Systematic Reviews

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Background-Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Surgical treatments for CIN are commonly associated with blood loss. Objectives-To assess the effectiveness and safety of interventions for preventing blood loss during the treatment of CIN. Search methods-We searched the Cochrane Gynaecological Cancer Group Trials Register, MEDLINE, EMBASE and CENTRAL up to April 2009. We also searched registers of clinical trials, abstracts of scientific meetings and reference lists of included studies. Selection criteria-Randomised controlled trials (RCTs) of vasopressin, tranexamic acid, haemostatic sutures, Amino-Cerv or Monsel's solution in women undergoing surgery for CIN. Data collection and analysis-Two reviewers independently abstracted data and assessed risk of bias. Risk ratios comparing adverse events in women who received one of the interventions were pooled in a random-effects meta-analyses or included in single trial analyses. Main results-Twelve RCTs (N = 1602, of whom 1512 were assessed) were included. Vasopressin significantly reduced perioperative bleeding (mean difference (MD) = −100.80, 95% confidence interval (CI) −129.48 to −72.12) and was associated with a decreased risk of bleeding that required haemostatic sutures or further vasopressin, compared to placebo (risk ratio (RR) = 0.39, 95% CI 0.27 to 0.56).

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“…1989), non‐steroid anti‐inflammatory drugs have only a small effect on perceived pain (Al‐Kurdi et al . 1985) and direct infiltration of local anaesthetic reduces pain scores by 40% (Lee et al . 1986).…”

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confidence: 99%

Is transcutaneous electrical nerve stimulation of any value during cervical laser treatment?

Crompton

Johnson

Dudek

et al. 1992

BJOG

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Objective To assess the value of transcutaneous electrical nerve stimulation (TENS) during cervical laser therapy. Design Randomized three arm controlled clinical trial comparing (i) TENS, (ii) local anaesthetic and (iii) TENS plus local anaesthetic (direct infiltration of 2% lignocaine and 0.03 iu/ml octopressin). Setting Colposcopy Unit adapted to run randomized trials. Subjects 100 women with CIN and no previous experience of cervical surgery. Main outcome measure Visual linear analogue pain scores. Results The median pain score associated with TENS was greater than the score associated with local anaesthesia (23% compared with 17%; P= 0.1). Combining TENS with local anaesthesia did not further reduce pain scores. Conclusion Although there was considerable consumer satisfaction with TENS it provided no additional pain relieving effect in addition to direct infiltration of lignocaine and it is inferior to lignocaine alone. We are unable to advocate the use of TENS for laser treatment of the cervix.

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A randomized trial of Citanest with Octapressin for relief of pain associated with laser vaporization of the cervix

Cited by 23 publications

References 1 publication

Survey of use of local infiltration and vasoconstrictors in vaginal surgery

Survey of use of local infiltration and vasoconstrictors in vaginal surgery

Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia

Is transcutaneous electrical nerve stimulation of any value during cervical laser treatment?

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