A Randomized Trial of Integrated Group Therapy  Versus Group Drug Counseling for Patients With Bipolar Disorder and Substance Dependence

Weiss, Roger D.; Griffin, Margaret L.; Kolodziej, Monika E.; Greenfield, Margaret; Najavits, Lisa M.; Daley, Dennis C.; Doreau, Bastien; Hennen, John

doi:10.1176/ajp.2007.164.1.100

Cited by 184 publications

(116 citation statements)

References 32 publications

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“…At 6 months, patients receiving the cognitivebehavioral treatment targeting substance use and promoting coping skills for mood symptoms showed superior medication compliance, increased abstinence rates, and decreased manic symptoms relative to the comparison condition. In a recently published, larger, follow-up study of the same intervention, bipolar patients with comorbid substance dependence demonstrated significantly decreased substance use and higher retention rates in the cognitive-behavioral group compared with regular group drug counseling (Weiss et al, 2007). Even though studies of psychosocial treatments for bipolar disorder often exclude patients with current SUDs, it still may be necessary to ensure that treatment addresses the possibility of subsequent substance abuse given the fact that many patients will likely have a SUD history.…”

Section: Discussionmentioning

confidence: 99%

Impact of remitted substance use disorders on the future course of bipolar I disorder: Findings from a clinical trial

Gaudiano

Uebelacker

Miller

2008

Psychiatry Research

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Given the high lifetime prevalence rates of bipolar disorder and comorbid substance use disorders (SUDs), the aim of the study was to examine the effect of a remitted SUD on the future course of bipolar I disorder in patients taking part in a clinical trial. Patients with bipolar I disorder were enrolled in a larger study examining the effects of pharmacotherapy plus family interventions. These patients were recruited during an acute mood episode and their mood symptoms and substance abuse were assessed longitudinally for up to 28 months. Patients with a remitted SUD showed a poorer acute treatment response, a longer time to remission of their acute mood episode, and a greater percentage of time with subthreshold but clinically significant depression and manic symptoms over follow-up compared to those without this comorbidity pattern. Subsequent substance abuse during follow-up could not fully account for the poorer course of illness. As remitted SUDs appear to negatively predict treatment outcome, current findings have implications for both clinical trials of bipolar patients as well as clinical practice.

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Section: Discussionmentioning

confidence: 99%

Impact of remitted substance use disorders on the future course of bipolar I disorder: Findings from a clinical trial

Gaudiano

Uebelacker

Miller

2008

Psychiatry Research

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“…This study used baseline data collected from two clinical trials of manualized group therapy for patients with BD and SUD (see Weiss et al, 2000Weiss et al, , 2007. Inclusion criteria were current diagnoses of BD and alcohol/drug dependence, substance use in past 60 days, and a mood stabilizer regimen.…”

Section: Participants and Proceduresmentioning

confidence: 99%

HIV risk behavior among patients with co-occurring bipolar and substance use disorders: Associations with mania and drug abuse

Meade

Graff

Griffin

et al. 2008

Drug and Alcohol Dependence

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Background-Bipolar and substance use disorders frequently co-occur, and both are associated with impulsivity, impaired judgment, and risk-taking.Objectives-This study aimed to: (1) describe the rates of HIV sexual and drug risk behaviors among patients with co-occurring bipolar and substance use disorders, (2) test whether acute mania, psychiatric severity, and drug severity independently predict HIV risk, and (3) examine the relationship between specific substance dependencies and sexual risk behaviors.Method-Participants (N = 101) were assessed for psychiatric diagnoses, substance abuse, and HIV risk behavior using structured clinical interviews and self-report questionnaires.Results-The majority (75%) were sexually active in the past 6 months and reported high rates of sexual risk behaviors, including unprotected intercourse (69%), multiple partners (39%), sex with prostitutes (24%, men only), and sex trading (10%). In a multivariate linear regression model, recent manic episode, lower psychiatric severity, and greater drug severity were independent predictors of total HIV risk. Cocaine dependence was associated with increased risk of sex trading.Conclusions-Results underscore the importance of HIV prevention for this population.

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“…We have developed a new treatment, Integrated Group Therapy (IGT), which has been shown to reduce substance use (Weiss et al, 2000;Weiss et al, 2007). However, no studies have examined treatment retention specifically.…”

Section: Introductionmentioning

confidence: 99%

Predictors of dropout from group therapy among patients with bipolar and substance use disorders

Graff¹,

Griffin²,

Weiss³

2008

Drug and Alcohol Dependence

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Objective-Bipolar and substance use disorders frequently co-occur. Integrated treatment for these disorders has been shown to be effective at reducing substance use, but no study has examined attrition from dual diagnosis group therapy. The current study identified baseline demographic and clinical characteristics that predict treatment dropout among patients with co-occurring bipolar and substance use disorders.Method-Using binary and multivariate analyses, baseline data were analyzed as part of a randomized controlled trial of integrated group therapy for bipolar and substance use disorders.Results-Cigarette smoking, recent mood episode, and lack of a college education were strong predictors of dropout after controlling for demographic and substance use variables.Conclusions-Given the strength of smoking as a predictor of dropout as well as the high rate of smoking among this population, a greater focus on the relationship between smoking and bipolar disorder is warranted.

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A Randomized Trial of Integrated Group Therapy Versus Group Drug Counseling for Patients With Bipolar Disorder and Substance Dependence

Abstract: Integrated group therapy, a new treatment developed specifically for patients with bipolar disorder and substance dependence, appears to be a promising approach to reduce substance use in this population.

Cited by 184 publications

References 32 publications

Impact of remitted substance use disorders on the future course of bipolar I disorder: Findings from a clinical trial

Impact of remitted substance use disorders on the future course of bipolar I disorder: Findings from a clinical trial

HIV risk behavior among patients with co-occurring bipolar and substance use disorders: Associations with mania and drug abuse

Predictors of dropout from group therapy among patients with bipolar and substance use disorders

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