A randomized trial of the effect of moistening misoprostol before vaginal administration when used with methotrexate for abortion

Alternatives to mifepristone for early medical abortion

“…Although cumulative serum levels are higher after administration of moistened misoprostol, there were no differences in success rates between moistened and dry misoprostol in randomized clinical trials [21][22][23].…”

“…In women with a pregnancy duration less than 49 days, the reported success rate after administration of 50/m 2 mg of oral methotrexate followed by 800 mcg of vaginal misoprostol was between 90% and 91% [26,43]. When 50 mg/m 2 of intramuscular methotrexate was followed by 800 mcg of vaginal misoprostol in women with a pregnancy duration less than 49 days, however, the observed success ranged between 75% and 95% [23,27,42,44].…”

“…Surgical interventions for true method failure (continuing pregnancy) ranged from 0.4% to 8% [20,23,[25][26][27]29,42,43,47,48]. Surgical procedures deemed medically indicated because of excessive bleeding, incomplete abortion, and infection ranged from 0.3% to 5.0% [20,23,25,42,47].…”

Drug Methods for Arteficial Termination of Unwanted Pregnancy

“…The first researches, made by patiens have shown the low level of success, what is about 5% to 11% if it's applied in dose at 400µg per per oral (34). Later studies in which misoprostole administered vaginally in a dose of 200-800µg, showing success in a range of complete abortion of 20% to 60% (35,36). Unlike these first studies some autors as Carbonell and associates (37) and Esteve and associates (38) have shown the rate of 90% complete abortion repeated intravaginal application of moistened tablets misoprostole in total dose of 800 µg at pregnancy less than 56 of 63 gestation days.…”

Tratamiento médico del aborto espontáneo del primer trimestre

“…59 No existe diferencia clínicamente significativa entre la administración del misoprostol vaginal administrado sin humedecer y humedecido con agua, suero salino o ácido acético. 63,64 3. La vía rectal tiene u patrón similar a la administración vaginal, pero presenta un AUC más baja, incluyendo un pico máximo de concentración significativamente más bajo 65 .…”