A randomized trial of the acceptability of a daily multi‐allergen food supplement for infants

Holl, Jane L.; Bilaver, Lucy; Finn, Daniel J.; Savio, Kay

doi:10.1111/pai.13223

Cited by 17 publications

(23 citation statements)

References 8 publications

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“…This study had a high completion rate indicating acceptability, and showed no significant difference in safety between the active vs. the placebo group (p = 0.76). There were no increases in adverse events and there were no increases in reported IgE-type allergic reactions in the active vs. the placebo group [20]. In fact, the placebo group had allergic reactions likely due to the delayed introduction of allergenic foods.…”

Section: Introductionmentioning

confidence: 77%

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

et al. 2022

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The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4–6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.

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Section: Introductionmentioning

confidence: 77%

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

et al. 2022

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show abstract

“…This study had a high completion rate indicating acceptability and showed no significant difference in safety between the active vs placebo group (p=0.76). There were no increases in adverse events and there were no increases in reported IgEtype allergic reactions in the active vs. placebo group (20). In fact, the placebo group had allergic reactions likely due to delayed introduction of allergenic foods.…”

Section: Introductionmentioning

confidence: 77%

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy

Quake¹,

Liu²,

D’Souza³

et al. 2021

Preprint

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The incidence and prevalence of food allergy (FA) are increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants particularly in those at high or low risk of atopy are still unclear. This 1-year study evaluated the safety of early introduction of single foods (milk, egg, or peanut), vs. two foods (milk/egg, egg/peanut, milk/peanut), vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/fish/soy at low, medium, or high doses) vs no early introduction in infants between 4-6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity with standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixture was 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least 6 months of age. Results demonstrate that infants at either high or low risk for atopy were able to tolerate early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that early introduction of foods, particularly simultaneous mixtures of many allergenic foods is efficacious for preventing FA and can occur safely.

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“…to be a potentially convenient, well-accepted way to incorporate common allergens into the diet 52 ; however, the efficacy of these products for food allergy prevention has yet to be demonstrated.…”

Section: Pr Ag Mati C Appli C Ati On Of the Current E Viden Ce And In...mentioning

confidence: 99%

A pragmatic approach to infant feeding for food allergy prevention

McWilliam

Venter

Greenhawt

et al. 2022

Pediatric Allergy Immunology

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Early introduction of allergenic foods into the infant's diet in the first year of life is currently the most promising strategy to prevent food allergy. Around 2015, the publication of the Learning Early About Peanut Allergy (LEAP) randomized controlled trial (RCT) led to a paradigm shift in infant feeding practices, moving away from delayed introduction to deliberate early introduction of common allergenic foods, especially peanut. LEAP showed early and regular consumption of peanut in high-risk infants resulted in an 81% relative risk

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A randomized trial of the acceptability of a daily multi‐allergen food supplement for infants

Cited by 17 publications

References 8 publications

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy

A pragmatic approach to infant feeding for food allergy prevention

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