A Randomized, Triple‐Blind, Placebo‐Controlled, Add‐On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension

Abstract

Introduction. Emblica officinalis (EO) has some cardiovascular effects, and there are some animal studies that show its antihypertensive effect. This study was conducted to determine the effect of combination of EO with standard therapy on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with uncontrolled hypertension. Materials and Methods. This was a randomized, triple-blind, placebo-controlled, 8-week study. Ninety-two patients with uncontrolled hypertension despite taking hypotensive drugs were randomly assigned into two groups to take EO (500 mg/TDS after meal) or placebo in combination with standard antihypertensive drugs. After 2, 4, 6, and 8 weeks of intervention, SBP and DBP and heart rate (HR) were measured. Data were analyzed by SPSS software using repeated measures ANOVA. Results. Eighty-one patients (41 in the drug group and 40 in the placebo group) completed the study for 8 weeks and were analyzed. The mean ± standard deviation of age was 53.64 ± 10.01 years. SBP decreased as 15.6 ± 8.23% in the EO group and 6.3 ± 7.49% in the placebo group ( P < 0.001 ). DBP decreased as 12.3 ± 7.87% and 3.88 ± 7.98%, respectively ( P < 0.001 ). Time effect was not significant, but the group effect was significant (F = 13.875, P = 0.001 for systolic BP and F = 18.948, P < 0.001 for diastolic BP). No side effects were reported during the study. Conclusion. Eight-week combination therapy of EO with standard antihypertensive drugs significantly reduced the SBP and DBP more than placebo in patients with uncontrolled hypertension.

Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties

“…Likewise, diastolic blood pressure showed a notable decrease of 12.3% ± 7.87% in the P. emblica group, in contrast to a 3.88% ± 7.98% decrease in the placebo group. Importantly, throughout the study duration, no toxic side effects were observed in any of the patients, underscoring the safety profile of P. emblica in this context (Ghaffari et al, 2020). For a visual representation of the mechanism, please refer to Figure 7.…”

“…In a rigorously conducted study by Ghaffari et al (2020), a randomized, triple-blind, and placebo-controlled research approach was employed to investigate the antihypertensive effects of P. emblica. The study included 92 patients who were randomly Frontiers in Pharmacology frontiersin.org 14 assigned to two groups.…”

Phytochemicals-linked food safety and human health protective benefits of the selected food-based botanicals

“…In the current study, the ACE inhibitory activity of the amla powder and kokum (powder and slice) extracts was found to be high even at one-fifth dilutions of the extracts, thereby indicating their potent antihypertensive activity. In a clinical study, an eight-week combination therapy of amla with antihypertensive drugs was found to significantly reduce the systolic blood pressure and diastolic blood pressure in patients with hypertension when compared to control (placebo) group [ 66 ]. In the current study, the in vitro ACE inhibition results indicates that amla and kokum, in addition to the other selected botanicals, can be incorporated in dietary support strategies as slices or powder to counter chronic hypertension commonly associated with type 2 diabetes and other NCDs.…”

Kombinasi Yoga dan Herbal dalam Pengobatan Beserta Efektivitasnya

“…Berbagai teknik yoga mulai dari relaksasi, pernafasan, hingga praktek terintegrasi telah diteliti mampu mengatasi hipertensi (Tyagi & Cohen, 2014). Setiap bahan-bahan pada ramuan Rasahara secara tunggal telah dibuktikan efek antihipertensinya baik pada percobaan ke manusia ataupun hewan (Ghaffari et al, 2020;Prasad et al, 2017;Sahoo et al, 2015).…”