A rapid, acetonitrile-free, HPLC method for determination of melamine in infant formula

Venkatasami, Gopalakrishnan; Sowa, John R.

doi:10.1016/j.aca.2010.03.037

Cited by 198 publications

(104 citation statements)

References 12 publications

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“…64 The LOD and LOQ levels were calculated for the existing ATR-IR system coupled with different types of fiber optic probes. Three types of fiber optic probes were tested: DiComp probe, Flow-Cell probe and K4 probe.…”

Section: Limit Of Detection (Lad) and Limit Of Quantitation (Loq) Datamentioning

confidence: 99%

Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies

Kassis

Bhawtankar

Sowa

2010

Journal of Pharmaceutical and Biomedical Analysis

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[ii] "Although nature commences with reason and ends in experience it is necessary for us to do the opposite, that is to commence with experience and from this to proceed to investigate the reason."-Leonardo da Vinci [iii] Abstract Attenuated Total Reflection Infrared Spectroscopy (ATR-IR) as an in situ Technique for Dissolution StudiesDissolution studies are critical tests for measuring the performance, or rate of release, of a drug product. There are many variables that affect the dissolution rate of the drug. Such variables may include characteristics of the active pharmaceutical ingredient (API) (e.g., particle size, crystal form, and bulk density), drug product composition (e.g., drug loading, and the identity, type, and levels of excipients), the drug product manufacturing process (e.g., compreSSIon forces, equipment), and the effects of stability storage conditions (e.g., temperature, humidity). Since dissolution has the ability to detect these variables, the regulatory agencies (i.e. FDA and EMEA) have placed great emphasis on the test. Moreover, the regulatory agencies have increased the monitoring and auditing of the dissolution test.A novel technique using in situ attenuated total reflection-infrared spectroscopy (ATR-IR) to monitor dissolutions of pharmaceutical drug products was developed. The accuracy of this technique is ±3% relative to HPLC. Salicylic acid calibrator tablets were studied and two over-the-counter (OTe) formulations containing acetaminophen, and/or acetylsalicylic acid were tested during the research. This novel approach was also used to analyze multiple components in a single tablet. For example, dissolution of the individual components of caffeine-free version of Excedrin® tablets, acetaminophen and acetylsalicylic acid were easily distinguished.[iv]

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Section: Limit Of Detection (Lad) and Limit Of Quantitation (Loq) Datamentioning

confidence: 99%

Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies

Kassis

Bhawtankar

Sowa

2010

Journal of Pharmaceutical and Biomedical Analysis

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“…In addition to retention time confirmation, the spectrometric profile of MEL recorded between 200 and 400 nm has been used to confirm the identity of a selected peak. However, the detection limit is around the parts per million (ppm) level (Kim et al, 2008;Muniz-Valencia et al, 2008;Chou et al, 2003;Lutter et al, 2011;Venkatasami & Sowa, 2010). Gas chromatography (GC), and HPLC coupled with single stage mass spectrometry (MS) or tandem mass spectrometry (MS/MS) are frequently used for the analysis of MEL and related compounds.…”

Section: Selective Quantitative Methodsmentioning

confidence: 99%

“…Retention times are prolonged for polar compounds and sensitivity is enhanced in mass spectrometry. Other methods use reversed-phase C18 or C8 columns (Lin et al, 2008;Venkatasami & Sowa Jr, 2010;Ibánez et al, 2009;Lutter et al, 2011). Recently, UPLC has been introduced in this field.…”

Section: Chromatographic and Mass Analysis (Ionization Fragmentationmentioning

confidence: 99%

“…Precision evaluation is measured as repeatability (intra-day) and reproducibility (inter-day) of samples as demonstrated by injection (in triplicate) of the sample on the initial day and three consecutive days (Venkatasami & Sowa, 2010 (Breidbach et al, 2009). Laboratories from 31 countries including Taiwan and 21 of the 27 member states of the European Union participated.…”

Section: Performance Testmentioning

confidence: 99%

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Application of Tandem Mass Spectrometry for Analyzing Melamine

Cheng¹,

Wang²

2012

Tandem Mass Spectrometry - Applications and Principles

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“…Due to the aforementioned nitrogen content, counting for two thirds of its molecular mass, adulteration of dairy products with melamine has been employed as a method of artificially augmenting the apparent crude protein content (9) and as a cheap food supplement in cattle feed (10). Contamination of infant formula and pet food with melamine has caused a global scandal following the deaths of a number of babies and the hospitalisation of several thousand more (11).…”

Section: Introductionmentioning

confidence: 99%

Computational design of molecularly imprinted polymer for direct detection of melamine in milk

Bates

Busato

Piletska

et al. 2017

Separation Science and Technology

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A novel protocol for use of molecularly imprinted polymer (MIP) in analysis of melamine is presented. Design of polymer for melamine has been achieved using a combination of computational techniques and laboratory trials, the former greatly reducing the duration of the latter. The compatibility and concerted effect of monomers and solvents were also investigated and discussed. Two novel open source tools were presented which are: the online polymer calculator from mipdatabase.com and the application of the Gromacs modelling suite to determine the ideal stoichiometric ratio between template and functional monomer. A c c e p t e d M a n u s c r i p t 2

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A rapid, acetonitrile-free, HPLC method for determination of melamine in infant formula

Cited by 198 publications

References 12 publications

Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies

Attenuated total reflection infrared spectroscopy (ATR-IR) as an in situ technique for dissolution studies

Application of Tandem Mass Spectrometry for Analyzing Melamine

Computational design of molecularly imprinted polymer for direct detection of melamine in milk

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