A Rapid and Convenient Microwave-Promoted Synthesis of 3,5-Disubstituted 2-Chloropyridines and Their Conversion into Tetrazolo[1,5-a]pyridines

Boruah, Romesh C.; Gogoi, Shyamalee; Gogoi, Sanjib

doi:10.1055/s-0032-1317930

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2024

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Cited by 4 publications

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ChemInform Abstract: A Rapid and Convenient Microwave‐Promoted Synthesis of 3,5‐Disubstituted 2‐Chloropyridines and Their Conversion into Tetrazolo[1,5‐a]pyridines.

Gogoi

Boruah

2013

ChemInform

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A Rapid and Convenient Microwave-Promoted Synthesis of 3,5-Disubstituted 2-Chloropyridines and Their Conversion into Tetrazolo[1,5-a]pyridines. -New 2-chloropyridines are synthesized from α,β-unsaturated ketoximes via microwave-assisted Vilsmeier reaction. A following reaction with sodium azide gives tetrazolopyridines in good yields. -(GOGOI, S.; GOGOI, S.; BORUAH*, R. C.; Synthesis 45 (2013) 2, 219-224, http://dx.doi.org/10.1055/s-0032-1317930 ; Med. Chem. Div., North-East Inst. Sci. Technol., Jorhat 785 006, India; Eng.) -Mais 18-134

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ChemInform Abstract: A Rapid and Convenient Microwave‐Promoted Synthesis of 3,5‐Disubstituted 2‐Chloropyridines and Their Conversion into Tetrazolo[1,5‐a]pyridines.

Gogoi

Boruah

2013

ChemInform

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Synthesis of pyridines

Kaur

2024

Synthesis of 6- And 7-Membered Heterocycles

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Facile Diversity-Oriented Synthesis of Polycyclic Pyridines and Their Cytotoxicity Effects in Human Cancer Cell Lines

Goswami

Gogoi

et al. 2016

ACS Comb. Sci.

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A three-component cascade method has been developed for the direct synthesis of polysubstituted pyridines. This strategy provides a very convenient route to pyridines using a variety of β-bromo-α,β-unsaturated aldehydes, 1,3-diketones, and ammonium acetate without any additional catalyst or metal salt under mild conditions. A variety of β-ketoesters and 4-hydroxycoumarin were also used instead of 1,3-diketones for the diverse synthesis of polycyclic pyridines. One of the synthesized pyridines has been unambiguously established by a single crystal XRD study. All of the synthesized pyridine derivatives were evaluated for their antiproliferative properties in vitro against the human cancer cell lines HeLa, Me180, and ZR751. Compounds 4{4,1} and 4{2,4} showed significant cytotoxicity in the human breast cancer cell line ZR751 and cervical cancer cell line Me180, respectively, and a few other compounds were found to have moderate activities.

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A Rapid and Convenient Microwave-Promoted Synthesis of 3,5-Disubstituted 2-Chloropyridines and Their Conversion into Tetrazolo[1,5-a]pyridines

Cited by 4 publications

References 4 publications

ChemInform Abstract: A Rapid and Convenient Microwave‐Promoted Synthesis of 3,5‐Disubstituted 2‐Chloropyridines and Their Conversion into Tetrazolo[1,5‐a]pyridines.

ChemInform Abstract: A Rapid and Convenient Microwave‐Promoted Synthesis of 3,5‐Disubstituted 2‐Chloropyridines and Their Conversion into Tetrazolo[1,5‐a]pyridines.

Synthesis of pyridines

Facile Diversity-Oriented Synthesis of Polycyclic Pyridines and Their Cytotoxicity Effects in Human Cancer Cell Lines

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