A Rapid Expansion of HIV-1 CRF63_02A1 Among Newly Diagnosed HIV-Infected Individuals in the Tomsk Region, Russia

Gashnikova, N. M.; Bogachev, V. V.; Baryshev, Pavel; Av, Totmenin; Gashnikova, Maria P.; Kazachinskaya, Anastasia G; Ismailova, Tatiana N; Stepanova, Svetlana A; Chernov, A. S.; Михеев, В. Н.

doi:10.1089/aid.2014.0375

Cited by 23 publications

(27 citation statements)

References 7 publications

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“…В подгруппе Сибирского федерального округа (СФО), представленной девятью исследованиями [6,7,15,26,27], обобщенная распространенность рекомбинантных форм ВИЧ составила 33,2% (95% ДИ 12,2-54,1) и характеризовалась высокой гетерогенностью (I 2 = 99,6%, p < 0,001; рис. 2).…”

Section: анализ в подгруппахunclassified

“…В основе формирования рекомбинантных форм лежит двойное инфицирование больных, которое может происходить из-за одновременного заражение двумя и более гетерологичными штаммами (коинфекция) или последовательного инфицирования, в котором второе инфицирование происходит после сероконверсии к первичной инфекции (суперинфекция) [26,27,29].…”

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The Prevalence of Hiv Recombinant Forms in Russia and Countries of the Cis: Systematic Review and Metaanalysis

Pasechnik

Блох

2018

Russian Journal of Infection and Immunity

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This review was to aimed to access the prevalence of HIV recombinant forms in Russia and countries of the CIS, which have close social and economic ties. We conducted a search in Russian Science Citation Index and PubMed for a depth of 8 years. We included 22 articles, which contained the results of 35 independent cross-sectional studies, in our review. Meta-analysis of HIV recombinant forms prevalence was conducted in Open Meta-analyst with the use of Der Simonian & Laird method, arcsin transformation and correction factor for zero values. Subgroup analysis was used along with meta-regression (by date of collection). Pooled prevalence of HIV recombinant forms was 21.3% (95% CI 16.2–26.5) and was highly heterogeneous. Blood samples from 3,494 HIV patients living in various regions of the Russian Federation and CIS countries — Belarus, Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan, Armenia, Georgia — were examined. Among subtypes of HIV-1, the main share was occupied by subtype A — 75.6% (n = 2643), subtype B — 5.5% (n = 193), C — 0.8% (n = 31), G — 0.2% (n = 7), F — 0.14% (n = 5). Among the recombinant forms (n = 616), the fraction of CRF02_ AG was 39.6% (n = 244), CRF02_AG/A was 32.9% (n = 203), CRF63_02A1 was 15.9% (n = 98), CRF03_AB — 5.2% (n = 32), CRF06_cpx — 2.1% (n = 13). Unique recombinant forms were 2.7% (n = 17), including URF63_A1 (2.5%). In Russia, the highest prevalence of recombinant forms of HIV-1 was registered in the Siberian Federal District (33.2% (95% CI 12.2– 54.1), the lowest in the Northwest Federal District — 1.6% (95% CI 0.9–2.3). In the CIS countries, the highest prevalence of recombinant forms of HIV-1 is found in a subgroup of the Central Asian republics — Uzbekistan, Tajikistan, Kyrgyzstan, Kazakhstan — 51.7% (95% CI 38.5–64.9). The significant upward trend was shown with a meta-regression. Our review is the first such research in Russia and thus is of significant interest, but the result should be applied with caution due to high risk of publication bias as well as significant heterogeneity of our results.

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Section: анализ в подгруппахunclassified

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The Prevalence of Hiv Recombinant Forms in Russia and Countries of the Cis: Systematic Review and Metaanalysis

Pasechnik

Блох

2018

Russian Journal of Infection and Immunity

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“…In 2007-2008, an increase in morbidity rate was observed, with the following relative stabilization but with higher quantitative indices of HIV distribution [ 7 ]. In 2013-2014, an epidemic outbreak in adjacent Tomsk Oblast was observed with 6- to 10-fold increase in newly registered HIV infection cases in the PWID group; Kemerovo Oblast, Novosibirsk Oblast, Omsk Oblast, Altai Krai, and Krasnoyarsk Krai demonstrated an increase in morbidity rates [ 8 ]. Starting in 2010, territory epidemics expansion in SFD has been caused by the beginning of synthetic drugs spreading [ 9 ], switching from opioid drugs to the new psychoactive substances (the so-called “synthetics” and “salts”) among PWID, and the involvement of large amount of population into the use of such drugs.…”

Section: Introductionmentioning

confidence: 99%

“…As distinct from the European part of Russia, Urals, and Far East with currently predominant HIV-1 subtype A specific to Russia [ 14 – 20 ], after 2010–2014 in Novosibirsk Oblast, Tomsk Oblast, Kemerovo Oblast, and Altai Krai, 85% of newly detected HIV infections were caused by circulating recombinant form (CRF) HIV-1 63_02A1 [ 7 , 8 , 21 , 22 ]. Furthermore, according to several studies, in Irkutsk Oblast up to 2012 and in Krasnoyarsk Krai up to 2008 exclusively Russian HIV-1 subtype A (A6) was detected [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia

Maksimenko

Gashnikova

et al. 2020

BioMed Research International

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More than a quarter of HIV-infected individuals registered in Russia live in Siberia. Unlike Central Russia where HIV-1 subtype A6 is predominant, in most Siberian regions since 2012, a new HIV-1 CRF63_02A1 genetic variant has spread, with the share of this variant attaining 75–85% among newly identified HIV cases. Krasnoyarsk Krai is considered to be a high-risk territory according to morbidity rate and HIV infection incidence among the population. The current paper aims to study the molecular epidemiologic characteristics of HIV-1 spreading in Krasnoyarsk Krai. Phylogenetic and recombination analyses of pol (PR-RT, IN) and env regions of the virus were used for genotyping 159 HIV-1 isolated in Krasnoyarsk Krai. 57.2% of the isolates belonged to subtype A (A6) specific to Russia, 12.6% to CRF63_02A1, and 0.6% to CRF02_AGСА, and in 29.6% HIV-1 URFs were detected, including URF63/А (23.9%), URFА/В (4.4%), and URF02/А (1.3%). In 6 of 7, HIV-1 URFА/В identical recombination model was detected; the origin of 38 URF63/А was proven to be the result of individual recombination events. Since 2015, a share of the population with newly diagnosed HIV who were infected with HIV-1 URF reached an exceptionally high rate of 38.6%. As distinct from adjacent Siberian regions, the HIV-1 CRF63_02A1 prevalence rate in Krasnoyarsk Krai is within 16%; however, the increased contribution of new HIV-1 into the regional epidemic development was observed due to the recombination of viruses of subtypes А, В, and CRF63_02A1. The difference between the described molecular epidemiologic picture in Krasnoyarsk Krai and in adjacent areas is likely caused by differences in predominant routes of HIV transmission and by more recent HIV-1 CRF63_02A1 transmission in the PWID group, which had a high prevalence of HIV-1 subtype A by the time of the new virus transmission, resulting in increased possibility of coinfection with various HIV-1 genetic variants.

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“…Эти штаммы встречались и продолжают встречаться в других регионах РФ, но все они обнаруживаются спорадически и эпидемиологически, как правило, связаны с Калининградской областью. В 2013 г. в Томске среди вновь инфицированных лиц превалировал вариант ВИЧ CRF63_02A1 [14]. Данная рекомбинантная форма впервые была выявлена и описана в Новосибирске в 2008 г.…”

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Molecular Epidemiological Analysis of Hiv Infection in Northern Seaports of Russia

Kazennova

Laga

Gromov

et al. 2017

Problems of Virology

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The results of the molecular-epidemiological analysis of HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports of Russia - were presented. In these seaports the HIV-1 variants belonging to subtype A1 were predominant (93% in Murmansk, 83% in Arkhangelsk). In addition to these variants, viruses of other subtypes such as B, C, D and recombinant forms CRF02_AG and CRF03_AB were identified. The heterogeneity of circulating HIV-1 variants was higher in Arkhangelsk than in Murmansk. According to the results of phylogenetic analysis, subtype A1 sequences formed the common branch with nucleotide sequences of IDU-A strains found in other regions of Russia. HIV-1 variants of subtype B sub-clustered with sequences of East European B-variants. The recombinant strains CRF02_AG formed the common branch with HIV-1 sequences from Central Asia republics of the former USSR. Among 124 therapy-naive patients from Arkhangelsk and Murmansk (n = 124) the transmitted resistance was less than 5%.

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A Rapid Expansion of HIV-1 CRF63_02A1 Among Newly Diagnosed HIV-Infected Individuals in the Tomsk Region, Russia

Cited by 23 publications

References 7 publications

The Prevalence of Hiv Recombinant Forms in Russia and Countries of the Cis: Systematic Review and Metaanalysis

The Prevalence of Hiv Recombinant Forms in Russia and Countries of the Cis: Systematic Review and Metaanalysis

Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia

Molecular Epidemiological Analysis of Hiv Infection in Northern Seaports of Russia

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