A rapid phase transfer method for nanoparticles using alkylamine stabilizers

Wang, Xinnan; Xu, Shuping; Zhou, Ji; Xu, Weiqing

doi:10.1016/j.jcis.2010.03.068

Cited by 39 publications

(39 citation statements)

References 42 publications

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“…This is likely due to acetone being miscible with water, thereby maximizing contact between AuNPs and the surfactant/capping reagent. Although other reports showed successful transfer using ethanol as the intermediate solvent, 33 we noted AuNP aggregation with this solvent under the conditions used in our studies. Acetone, on the other hand, did not cause AuNP aggregation, allowed favorable mixing and ensured successful transfer into chloroform under acidic pH.…”

Section: Discussioncontrasting

confidence: 54%

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

Chuang¹,

Shon²,

Narayanaswami³

2017

IJN

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We have developed a high-density lipoprotein (HDL)-based platform for transport and delivery of hydrophobic gold nanoparticles (AuNPs). The ability of apolipoprotein E3 (apoE3) to act as a high-affinity ligand for the low-density lipoprotein receptor (LDLr) was exploited to gain entry of HDL with AuNPs into glioblastoma cells. AuNPs of 3, 10, and 17 nm diameter, the latter two synthesized by phase transfer process, were solubilized by integration with phospholipids and apoE3, yielding reconstituted HDL (rHDL) bearing AuNPs. Ultraviolet–visible spectra of rHDL-AuNP indicated the presence of stable particles with surface plasmon band at ~530 nm. Transmission electron microscopy (TEM) of rHDL-AuNP revealed roughly spherical particles with AuNPs embedded in the core. The rHDL-AuNP particles displayed robust binding to the LDLr and were internalized by receptor-mediated endocytosis in glioblastoma cells. Confocal microscopy confirmed cellular uptake of AuNPs in the endosomal–lysosomal compartments, while TEM revealed intracellular aggregated AuNPs. Cell viability assay demonstrated that >85% of cells were viable with rHDL-AuNP treatment of 0.1–100 μg/mL for 24 hours. These findings are significant since they offer an effective means of delivering AuNPs across the cell membrane, which is particularly relevant in tumor cells that overexpress LDLr.

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Section: Discussioncontrasting

confidence: 54%

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

Chuang¹,

Shon²,

Narayanaswami³

2017

IJN

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“…, reversed micelles process 9, 15 , reduction of metal ions in the organic phase in the presence of a capping agent 11, 16, 17 or the phase transfer process from the aqueous phase with phase transfer agents 12, [18][19][20][21][22] . Recently, the phase transfer process has become the main way to obtain monodisperse nanoparticles in organic solvents.…”

Section: 14mentioning

confidence: 99%

“…alkylamines 18,19 , thiols 12, 20, 21 , carboxy acids 22 , dithiophosphoric acids etc.). The main advantage of this process is that during the transfer of nanoparticles from water to organic solvent it is possible to remove all unwanted synthesis reagents (by-products of the synthesis, unbounded stabilizers and water) that may have a negative impact, especially in the case of their usage in electronic applications.…”

Section: 14mentioning

confidence: 99%

The influence of the chain length and the functional group steric accessibility of thiols on the phase transfer efficiency of gold nanoparticles from water to toluene

Soliwoda

Tomaszewska

Tkacz‐Szczesna

et al. 2014

Polish Journal of Chemical Technology

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This paper describes the infl uence of the chain length and the functional group steric accessibility of thiols modifi ers on the phase transfer process effi ciency of water synthesized gold nanoparticles (AuNPs) to toluene. The following thiols were tested: 1-decanethiol, 1,1-dimethyldecanethiol, 1-dodecanethiol, 1-tetradecanethiol and 1-oktadecanethiol. Nanoparticles (NPs) synthesized in water were precisely characterized before the phase transfer process using Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM). The optical properties of AuNPs before and after the phase transfer were studied by the UV-Vis spectroscopy. Additionally, the particle size and size distribution before and after the phase transfer of nanoparticles were investigated using Dynamic Light Scattering (DLS). It turned out that the modifi cation of NPs surface was not effective in the case of 1,1-dimethyldecanethiol, probably because of the diffi cult steric accessibility of the thiol functional group to NPs surface. Consequently, the effective phase transfer of AuNPs from water to toluene did not occur. In toluene the most stable were nanoparticles modifi ed with 1-decanethiol, 1-dodecanethiol and 1-tetradecanethiol.

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“…Larger hydrophobic AuNPs than 10 nm exhibit appreciable near-field enhancement and thus are superior in terms of enhancement effects 20 . In fact, Wang et al 21 and Baik et al 22 reported the larger hydrophobic AuNPs prepared by the two-step approaches: preparation of hydrophilic AuNPs (10-100 nm) and then hydrophobization with alkylamine or alkanethiols. However, these methods have some disadvantages, such as complicated and timeconsuming procedures, less isolated AuNPs, and poor redispersal ability even after concentrating or drying.…”

Section: Introductionmentioning

confidence: 99%

Vibrational Spectroscopic Studies on the Formation Processes and Characteristics of Octadecanethiol Monolayers on the Surfaces of Gold Nanoparticles

Ishida

Tachikiri

Takahashi

et al. 2015

Trans. Mat. Res. Soc. Japan

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The preparation method of hydrophobic gold nanoparticles (AuNPs) with the diameters of 17, 30 and 48 nm has been developed. So as to clarify the size effects of AuNPs on the hydrophobization processes, time courses for the formation of the self-assembled monolayers (SAMs) of octadecanethiol (ODT) molecules on the surfaces of the AuNPs have been investigated by means of FT-IR and Raman spectroscopies. In all cases, the alkyl chains were mainly arranged as all-trans conformation (solid-like) at the completion of the reaction. Observation of the time course of ODT-SAM formation revealed that smaller curvature (larger size) resulted in the faster formation of SAM because of smaller conical volume snugly available for the alkyl chain on the surface of the AuNP.

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A rapid phase transfer method for nanoparticles using alkylamine stabilizers

Cited by 39 publications

References 42 publications

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles

The influence of the chain length and the functional group steric accessibility of thiols on the phase transfer efficiency of gold nanoparticles from water to toluene

Vibrational Spectroscopic Studies on the Formation Processes and Characteristics of Octadecanethiol Monolayers on the Surfaces of Gold Nanoparticles

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