A Rapid Progression of Disease After Surgical Excision of a Malignant Rhabdoid Tumor of the Bladder

Abstract

Extrarenal malignant rhabdoid tumors (MRTs) are rare tumors with a poor prognosis. Five-year overall survival for patients with MRTs is poor at approximately 20%.1 There are 5 case reports of histologically confirmed primary MRT of the bladder in pediatric patients. Herein, we report a case of an MRT of the bladder in a 14-year-old boy and discuss the preoperative evaluation, treatment options, and possible etiologies of metastasis after radical surgery.

Pure Bladder Malignant Rhabdoid Tumor Successfully Treated With Partial Cystectomy, Radiation, and Chemotherapy: A Case Report and Review of the Literature

“…MRTs originating from the bladder are scarce, with 8 pediatric cases reported with ages ranging between infancy and 17 years (ours being the second youngest) 5–11. Of those, 4 received neoadjuvant chemotherapy, with good response in 3 (75%).…”

“…Six cases reported follow-up of at least 1 year, with only 1 recurrence in a 14-year-old boy with metastatic disease at presentation, who died 3 months after surgery because of progression. 7 When compared with other extracranial MRTs, these reports regarding bladder MRT prognosis are encouraging, with a plausible explanation being that bladder MRTs induce gross hematuria, leading to relatively early diagnosis, whereas other sites may progress longer undetected.…”

“…4 MRTs originating from the bladder are scarce, with 8 pediatric cases reported with ages ranging between infancy and 17 years (ours being the second youngest). [5][6][7][8][9][10][11] Of those, 4 received neoadjuvant chemotherapy, with good response in 3 (75%). Five patients were managed with partial cystectomy, 2 required radical cystectomy, and 1 patient underwent transurethral resection of the tumor only.…”

Unusual Faces of Bladder Cancer

“…Its histogenesis is still unclear. A handful of rhabdoid tumors of the bladder have been published, particularly in children and young adults [ 63 , 64 , 65 ]. There are, however, isolated cases reported in adulthood [ 66 , 67 , 68 ].…”

Malignant rhabdoid tumors of soft tissues in children. Literature review

“…Единого подхода в терапии рабдоидных опухолей нет и проанализировать преимущества отдельных режимов ПХТ невозможно из-за малого числа па-циентов, что также наглядно отражено в представ-ленных клинических случаях [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70]. Показано, что на выживаемость влияет использование высоких доз алкилирующих агентов, в том числе антрациклино-вых антибиотиков и актиномицина D [9,80].…”