A rapid screening tool for fatigue impact in multiple sclerosis

Kos, Daphne; Nagels, Guy; D'hooghe, Marie B; Duportail, Marijke; Kerckhofs, Eric

doi:10.1186/1471-2377-6-27

Cited by 94 publications

(88 citation statements)

References 27 publications

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“…For example, most outpatient rehabilitation programs emphasize improvements in functional status, but such improvements may not be the most important sign of the success of an intervention program. Many researchers investigating MS patient population characteristics study constructs such as fatigue, [14][15][16][17] depression, 4,16 somatization, 5,11,13,34 self-efficacy, 17,33 fear, 10 pain, 30 and functional status. However, these constructs should not be considered independent.…”

Section: Discussionmentioning

confidence: 99%

“…10 In addition, depression and somatization 11 are recognized as common confounders of clinical outcomes, 12 including in people with MS. 4 The point prevalence of major depression may be as high as 17% in patients seen by primary-care providers, yet some believe the prevalence of depressive disorders in people with MS is much higher. The prevalence of somatization is difficult to assess, but it is common in people with MS. 5,13 Likewise, fatigue is common in people with MS. 14 Fatigue is a complex clinical phenomenon, 15 in part because it is associated with depression, 16 physical functioning, and self-efficacy. 17 A rapid screening tool, the Modified Fatigue Impact Scale (MFIS), was selected.…”

Section: Participants and Settingmentioning

confidence: 99%

“…17 A rapid screening tool, the Modified Fatigue Impact Scale (MFIS), was selected. 15,18 Finally, although pain may not be as prevalent as fatigue, depression, somatization, and low functional abilities in people with MS, because pain can affect each of these constructs, we felt that the assessment of pain intensity was warranted. 19 In order to facilitate efficient, simultaneous data collection involving several domains in real time, we explored advances in computerization for clinical practice.…”

Section: Participants and Settingmentioning

confidence: 99%

“…Summing responses produces scores ranging from 0 (low fatigue) to 84 (high impact of fatigue). Scores have been shown to be reliable, 18 with a good reproducibility intraclass correlation coefficient of >0.84 18 ; and valid, 14,15 with MFIS scores able to discriminate between people with and those without MS and a cut score of 59 or higher having diagnostic accuracy of 81% sensitivity and 77% specificity. 15 …”

Section: Statistical Analysesmentioning

confidence: 99%

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Developing a Wellness Program for People with Multiple Sclerosis

Hart¹,

Memoli²,

Mason³

et al. 2011

International Journal of MS Care

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Because multiple sclerosis (MS) is a multidimensional chronic disease, effective management of the illness requires a multidimensional approach. We describe a wellness program that was designed to facilitate positive health choices throughout the course of MS and present initial data analyses. We hypothesized that over the course of the program, participants would demonstrate improvement in the domains assessed. The wellness program included educational sessions in physical, mental, social, intellectual, and spiritual domains specifically targeting improved self-efficacy, physical functioning, coping skills, symptom management, and nutrition. An outcomes data collection software program was adapted to facilitate real-time patient self-report and clinician entry data collection for many domains throughout the wellness program. Initial assessment of serial measures (intake to discharge) from 65 people with MS showed improvement in several domains, including functional status (P < .05), fatigue (P < .05), fear-avoidance beliefs regarding physical activities (P < .05), depression (P < .05), somatization (P < .05), and pain (P < .05). In addition, using a model of risk for interpersonal distress, patients whose risk of elevated depression and anxiety decreased over the course of the program reported greater gains in functional status (P < .05). The results suggest possible future treatment strategies and indicate strengths and weaknesses of the wellness program, which are being used to improve the program. Int J MS Care. 2011;13:154-162.

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Section: Discussionmentioning

confidence: 99%

Section: Participants and Settingmentioning

confidence: 99%

Section: Participants and Settingmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

See 2 more Smart Citations

Developing a Wellness Program for People with Multiple Sclerosis

Hart¹,

Memoli²,

Mason³

et al. 2011

International Journal of MS Care

View full text Add to dashboard Cite

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“…Measurement of fatigue is usually accomplished by fatigue. 30 Reliability of the VASF has been established for other conditions but has not been examined in MS. 31 Although the FIS and FSS scales are reported to have greater test-retest reliability than the VASF, they were designed for measuring the effects of fatigue over time, not at a particular point in time, as in the present study. We used the VASF as the primary measure because it is reflective of immediate changes in fatigue.…”

Section: Participantsmentioning

confidence: 99%

Effect of a Single Bout of Intermittent versus Continuous Walking on Perceptions of Fatigue in People with Multiple Sclerosis

Karpatkin¹,

Rzetelny²

2012

International Journal of MS Care

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Fatigue may limit the ability of people with multiple sclerosis (MS) to participate in walking exercises, which could ultimately reduce their benefit from physical therapy. An exercise program that minimizes the fatigue experienced by people with MS during exercise may lead to an increase in the amount of exercise being performed. The purpose of this study was to determine whether subjective feelings of fatigue differ in people with MS depending on whether they exercised intermittently or continuously. Using a within-subjects, counterbalanced crossover design, a sample of 30 individuals with MS performed 6 minutes of continuous and 6 minutes of intermittent walking 1 week apart. Fatigue was measured on the Visual Analogue Scale of Fatigue (VASF) and recorded before and after the walking conditions. A 2 × 2 repeated-measures analysis of variance was used to assess the potential effects of intermittent versus continuous walking on self-reported fatigue. A significant interaction revealed that pre-post mean self-ratings of fatigue on the VASF increased less in the intermittent condition (from 37.93 mm to 44.83 mm; difference = 6.90 mm) compared with the continuous condition (from 34.33 mm to 54.43 mm: difference = 20.10 mm) (P < .001), suggesting that patients experienced less fatigue in the intermittent condition despite walking an equivalent total duration. The interaction effect was not influenced by age, gender, disease severity or duration, use of antispasticity medication, use of assistive devices, or mood. The results suggest that people with MS may be more tolerant of, and able to perform, greater amounts of exercise if they exercise intermittently. Int J MS Care. 2012;14:124-131.

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Temporal Pattern of Cortical Hypoxia in Multiple Sclerosis and Its Significance on Neuropsychological and Clinical Measures of Disability

Adingupu,

Evans,

Soroush

et al. 2023

Annals of Neurology

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ObjectiveMultiple sclerosis (MS) is a degenerative disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal damage. It has been hypothesized that hypoxia plays a role in the pathogenesis of MS. This study was undertaken to investigate the reproducibility of non‐invasively measured cortical microvascular hemoglobin oxygenation (StO2) using frequency domain near‐infrared spectroscopy (fdNIRS), investigate its temporal pattern of hypoxia in people with MS (pwMS), and its relationship with neurocognitive function and mood.MethodsWe investigated the reproducibility of fdNIRS measurements. We measured cortical hypoxia in pwMS, and the relationships between StO2, neurocognitive function, fatigue, and measures of physical disability. Furthermore, we cataloged the temporal pattern of StO2 measured at 1‐week intervals for 4 weeks, and at 8 weeks and ~1 year.ResultsWe show that fdNIRS parameters were highly reproducible in 7 healthy control participants measured over 6 days (p > 0.05). There was low variability between and within subjects. In line with our previous findings, we show that 33% of pwMS (n = 88) have cortical microvascular hypoxia. Over 8 weeks and at ~1 year, StO2 values for normoxic and hypoxic groups did not change significantly. There was no significant association between cognitive function and StO2. This conclusion should be revisited as only a small proportion of the relapsing‐remitting MS group (21%) was cognitively impaired.InterpretationThe fdNIRS parameters have high reproducibility and repeatability, and we have demonstrated that hypoxia in MS is a chronic condition, lasting at least a year. The results show a weak relationship between cognitive functioning and oxygenation, indicating future study is required. ANN NEUROL 2023

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A rapid screening tool for fatigue impact in multiple sclerosis

Cited by 94 publications

References 27 publications

Developing a Wellness Program for People with Multiple Sclerosis

Developing a Wellness Program for People with Multiple Sclerosis

Effect of a Single Bout of Intermittent versus Continuous Walking on Perceptions of Fatigue in People with Multiple Sclerosis

Temporal Pattern of Cortical Hypoxia in Multiple Sclerosis and Its Significance on Neuropsychological and Clinical Measures of Disability

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