A RAPID TEST OF ADRENOCORTICAL FUNCTION USING HOMACTID (SYNTHETIC αh1–28 ACTH)

Woodings, D; Young, Patricia N.

doi:10.1530/acta.0.0670470

Cited by 3 publications

(1 citation statement)

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“…The test of adrenocortical function with synthetic adrenocorticotrophic hormone has previously been established as applicable for clinical diagnostic use (6, 18,21,22). The results obtained in this way are similar to those obtained with natural ACTH hormone (5).…”

Section: Discussionmentioning

confidence: 61%

Adrenocortical Function of Patients Using Oral Contraceptives

Kauppila

Järvinen

Ylöstalo

et al. 1974

Acta Obstet Gynecol Scand

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The effects of different oral contraceptives on adrenocortical function were investigated by assaying photofluorimetrically the 11-OHCS content of the plasma during synthetic ACTH (Homactidm) test. The series consisted of 43 women, 27 of whom were taking combined or sequential contraceptives, and 8 low-getagen pills. The remaining 8 patients acted as controls. The plasma 11-OHCS level in the low-gestagen group was the same as that in the control group both before and during the test. The combined type contraceptive pills containing estrogen and gestagen had an elevating effect on the 11-OHCS level of the plasma. The 11-OHCS level in these groups was significantly higher both before and during the ACTH test than the corresponding level in the control group. The difference is assumed to be due to the increased transcorting content of the plasma and to the increased biological half-life of cortisol induced by estrogen.

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Section: Discussionmentioning

confidence: 61%

Adrenocortical Function of Patients Using Oral Contraceptives

Kauppila

Järvinen

Ylöstalo

et al. 1974

Acta Obstet Gynecol Scand

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Hepatic and Adrenocortical Function During Cyclophosphamide Stoss Therapy

Ylöstalo

Kauppila

Jouppila

et al. 1973

Acta Obstet Gynecol Scand

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Abstract. Forty‐one patients with ovarian cancer were investigated for the effect of cyclophosphamide stoss therapy on liver function. The patients were tested for serum bilirubin, alkaline phosphatase, aminotransferases (GOT, GPT) serum total proteins, and ten of them also underwent an intravenous galactose tolerance test. Serum total protein was found to decrease significantly during the cyclophosphamide stoss therapy. It was further noted that the number of pathological results for serum total bilirubin, alkaline phosphatase, GOT, and GPT increased during the treatment, whereas the number of pathological half‐lives of galactose tolerance decreased. Fifteen patients underwent 19 intramuscular Homactid tests before the beginning of cyclophosphamide stoss therapy and one and two weeks after the therapy. The responsiveness of the adrenal cortex two weeks after the therapy was found to be lower and shorter in duration, compared with the results obtained before the therapy. Cyclophosphamide stoss therapy was not found to cause any serious disorders of hepatic or adrenocortical function.

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