A rapidly growing nodule on the leg of an adolescent: A unique presentation of a non‐neural granular cell tumor

Hobbs, Landon K; Kozak, Merrick D; Gradecki, Sarah E.; McGahren, Eugene D.; Raghavan, Shyam S

doi:10.1111/cup.14197

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Cancer Therapy and Oncology International Journal1

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2023

2024

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“…The prognosis is usually good in most cases [7]. In our case, the patient with the subglottic mass is free of disease at 1-year follow-up [8][9][10][11][12].…”

Section: Cancer Therapy and Oncology International Journalmentioning

confidence: 99%

ALK Positive Non-Neural Granular Cell Tumour in Two Paediatric Patients- A Case Report

Ramchandran

2023

CTOIJ

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Non-neural granular cell tumour (PNNGCT) is a rare mesenchymal neoplasm of unknown lineage with prominent cytoplasmic granularity [1]. These tumors are more common in children and young adults, and commonly involve the back and extremities. A panel of immunostains is important to rule out other differential diagnoses. In contrast to conventional granular cell tumor (GCT), NNGCT lacks S100 expression, hence, NKI-C3 and anaplastic lymphoma kinase (ALK) stains can be particularly helpful in confirming the diagnosis. In addition, an underlying ALK gene rearrangement has been reported in a small subset of cases [2]. In general, most of these tumors appear to behave in a benign fashion, and conservative management is recommended. Our results demonstrate that NNGCT harbour ALK fusions, which suggests that NNGCT are molecularly diverse, and further substantiate NNGCT as distinct from GCT [3].

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“…The prognosis is usually good in most cases [7]. In our case, the patient with the subglottic mass is free of disease at 1-year follow-up [8][9][10][11][12].…”

Section: Cancer Therapy and Oncology International Journalmentioning

confidence: 99%