A rare bacteremia caused by Cedecea davisae in patient with chronic renal disease

Peretz, Avi; Simsolo, Claudia; Farber, Evgeny; Roth, Anna; Brodsky, Diana; Nakhoul, Farid

doi:10.12659/ajcr.889285

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…Cedecea lapagei is reported to be a Gram-negative, non-sporulating, motile, non/encapsulated, rod-shaped bacilli, which belongs to the Enterobacteriaceae family. Various species of this genus have been reported to be isolated from various clinical specimens including sputum, urine, cutaneous and oral ulcers etc 30 – 32 . Pending further molecular characterization, we will refer to this strain as Cedecea sp.…”

Section: Resultsmentioning

confidence: 99%

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Singh

Pandit

Jers

et al. 2021

Sci Rep

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With multidrug-resistant bacterial pathogens on the rise, there is a strong research focus on alternative antibacterial treatments that could replace or complement classical antibiotics. Metallic nanoparticles, and in particular silver nanoparticles (AgNPs), have been shown to kill bacterial biofilms effectively, but their chemical synthesis often involves environmentally unfriendly by-products. Recent studies have shown that microbial and plant extracts can be used for the environmentally friendly synthesis of AgNPs. Herein we report a procedure for producing AgNPs using a putative Cedecea sp. strain isolated from soil. The isolated bacterial strain showed a remarkable potential for producing spherical, crystalline and stable AgNPs characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. The concentration of produced nanoparticles was 1.31 µg/µl with a negative surface charge of − 15.3 mV and nanoparticles size ranging from 10–40 nm. The AgNPs was tested against four pathogenic microorganisms S. epidermidis, S. aureus, E. coli and P. aeruginosa. The nanoparticles exhibited strong minimum inhibitory concentration (MIC) values of 12.5 and 6.25 µg/µl and minimum bactericidal concentration (MBC) values of 12.5 and 12.5 µg/mL against E. coli and P. aeruginosa, respectively. One distinguishing feature of AgNPs produced by Cedecea sp. extracts is their extreme stability. Inductively coupled plasma mass spectrometry and thermogravimetric analysis demonstrated that the produced AgNPs are stable for periods exceeding one year. This means that their strong antibacterial effects, demonstrated against E. coli and P. aeruginosa biofilms, can be expected to persist during extended periods.

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Section: Resultsmentioning

confidence: 99%

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Singh

Pandit

Jers

et al. 2021

Sci Rep

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“…edecea davisae is an enterobacterium that can be responsible for human infections (1)(2)(3)(4). Cephalothin resistance has been already reported in this species, but the mechanism has not been yet elucidated (5).…”

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confidence: 99%

Characterization of a Novel AmpC β-Lactamase Produced by a Carbapenem-Resistant Cedecea davisae Clinical Isolate

Ammenouche

Dupont

Mammeri

2014

Antimicrob Agents Chemother

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A Cedecea davisae isolate, which was intermediate or resistant to third-generation cephalosporins and carbapenems, was recovered from a urine sample. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC ␤-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. A cloning experiment followed by phenotypic and enzymatic characterization identified a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne ␤-lactamases of the genera Enterobacter and Citrobacter. C edecea davisae is an enterobacterium that can be responsible for human infections (1-4). Cephalothin resistance has been already reported in this species, but the mechanism has not been yet elucidated (5).The aim of this work was to identify the mechanisms of resistance of a C. davisae clinical isolate that was resistant to almost all ␤-lactams. It was recovered from a 77-year-old woman who was hospitalized in an intensive care unit of the teaching hospital of Amiens. Eighteen days after a cardiac valve replacement, the patient had a hemorrhagic shock due to retroperitoneal bleeding. The urine sample recovered after nephrostomy was sent to the Laboratory of Bacteriology. It grew a Gram-negative rod (10 7 CFU/ml) that was identified as C. davisae FUR by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (Shimadzu, Marne la Vallée, France) and 16S rRNA sequencing. The patient was started successfully on intravenous ciprofloxacin for 7 days.

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“…Cedecea davisae ( C. davisae ), a member of the Enterobacteriaceae family, is a gram-negative, oxidase negative, lipase positive, non-sporulating motile rod-shaped bacteria [1]. It has been isolated from various clinical specimens including sputum (the most common source), urine, cutaneous and oral ulcers, scrotal abscesses, peritoneal dialysis fluid, and the gallbladder.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Cedecea Davisae Bacteremia Presenting as Biliary Sepsis

Kanakadandi

Sarao

Cunningham

2019

Cureus

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Cedecea davisae is a gram-negative, non-sporulating motile rod-shaped bacteria of the Enterobacteriaceae family. It is an opportunistic pathogen in advanced-aged patients with many comorbid diseases and the immunosuppressed. To the best of our knowledge, only 12 cases of C. davisae bacteremia have been reported in the literature. Here we discuss the 13th case of C. davisae bacteremia, which is the first reported case presenting as biliary sepsis.A 41-year-old female, on prednisone for minimal change disease, presented with nausea, vomiting, fever, and diarrhea. She had dry mucous membranes, scleral icterus, and elevated liver enzymes. Blood cultures revealed Cedecea davisae. She improved after management with broad-spectrum antibiotics.Further studies are needed to understand its role in the mode of transmission, the spectrum of infection, and treatment options. There is a need for physicians to be cognizant of emerging pathogens and address their antibiotic resistance profiles.

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A rare bacteremia caused by Cedecea davisae in patient with chronic renal disease

Cited by 16 publications

References 7 publications

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability

Characterization of a Novel AmpC β-Lactamase Produced by a Carbapenem-Resistant Cedecea davisae Clinical Isolate

A Rare Case of Cedecea Davisae Bacteremia Presenting as Biliary Sepsis

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