A rare case of a giant anterior mediastinal liposarcoma

Gaikwad, Namdeo Mahadeo; Srikrishna, S. V.; Kasturi, Srikanth

doi:10.1007/s12055-019-00871-6

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Primary mediastinal liposarcoma (PML) is an extremely rare disease with only 95 cases previously reported in the English literature, which account for 0.1%–0.75% of all mediastinal tumors, 1 and it can grow slowly and remain asymptomatic for several years. PML is usually asymptomatic until large enough to compress intrathoracic structures, causing dyspnea, chest pain, hoarseness, and superior vena cava syndrome.…”

Section: Introductionmentioning

confidence: 99%

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Rao,

Zhu,

Yang

2023

SAGE Open Medical Case Reports

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Liposarcoma is a carcinomatous mesenchymal tumor with various histologic features and is the most common soft tissue sarcoma originating in adipose tissue. Liposarcoma commonly occurs in the lower extremities and retroperitoneum but rarely in the mediastinum, specially extending into the thoracic cavity. We report a giant primary liposarcoma of the posterior mediastinum in a 63-year-old female who complained of cough, sputum, and pain in the right chest wall. A computed tomography scan of the chest showed a giant mass of 24 × 15 × 24 cm in the posterior mediastinum of the right thoracic cavity. After a thorough examination, no suspected lipomatous lesions were found elsewhere in the patient’s body. The patient underwent a thoracotomy to remove the mediastinal mass through a right thoracic approach. Subsequently, hematoxylin–eosin staining revealed dedifferentiated liposarcoma (DDL), immunohistochemistry showed positive expression of cyclin-dependent kinase 4, and murine double minute 2 (MDM2), in addition, fluorescence in situ hybridization for the MDM2 gene was also positive, which suggested DDL. The patient was discharged without any complications, and no metastasis or recurrence was observed after 19 months of follow-up. To provide a reference for clinical diagnosis and treatment, we reviewed and discussed the literature on primary liposarcoma of the mediastinum.

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Section: Introductionmentioning

confidence: 99%

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Rao,

Zhu,

Yang

2023

SAGE Open Medical Case Reports

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Imaging and Clinical Findings in a Series of Six Cases of Rare Primary Mediastinal Liposarcoma

Wong

Bass

Chen

et al. 2022

Radiology: Cardiothoracic Imaging

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Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case

Kiełbowski

Ruszel

Skrzyniarz

et al. 2022

JCM

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Background: Liposarcoma (LPS) is one of the most common soft-tissue sarcomas. However, intrathoracic LPS is rare, as only 1% of all LPS cases are found in the thorax. Methods: A systematic literature review through PubMed and Embase databases was performed. Only eligible case reports and case series reporting intrathoracic LPS in adult patients were included. Kaplan–Meier curves were calculated to evaluate the survival rate of included patients based on the histological subtype of LPS. Results: 123 studies reporting 197 patients were included. We added a case of a 69-year-old female patient with recurrent giant intrathoracic LPS. The primary tumor measured 15.1cm × 22.9 cm × 21.9 cm and weighed 3100 g. Six months later, the patient was admitted to the hospital with another intrathoracic tumor measuring 9.5 cm × 9 cm× 1.4 cm. The immunohistochemical studies showed expression of murine double minute 2 (MDM2) antigen in both primary and recurrent tumor cells. Conclusions: Dyspnea, chest pain, and cough were the most common symptoms reported in included studies. Overall, the 5-year survival rate was 62%. The highest survival was observed in well-differentiated LPS patients (80%) and the lowest in myxoid LPS (31%).

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A rare case of a giant anterior mediastinal liposarcoma

Cited by 3 publications

References 5 publications

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Imaging and Clinical Findings in a Series of Six Cases of Rare Primary Mediastinal Liposarcoma

Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case

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