A rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection

Jayaram, Pradeep; Wake, Charlotte

doi:10.3109/01443610903585218

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…In a recent review, Marquez and col leagues [l] found only 64 cases, including 3 of their own, and fewer than 10 cases have been reported in the ensuing 5 years [2][3][4][5][6][7], Fetal loss can occur in utero and, despite appropriate treatment, the case fatality rate approaches 50%. The triad of cutaneous, CNS, and ophthalmologic manifestations is helpful in establishing the diagnosis, but these are not reliably present, and other sites of involvement such as visceral, limb, and bone abnormal ities can alert clinicians to consider the diagnosis [1], Most infants diagnosed with intrauterine HSV infection are ill or have findings leading to initiation of a diagnostic evaluation for congenital infection at birth.…”

Section: Discussionmentioning

confidence: 99%

“…Intrauterine HSV infection is uncommon and the clinical presentation can vary, but failure to recognize congenitally acquired HSV infection can have devastating consequences. In a recent review, Marquez and colleagues [1] found only 64 cases, including 3 of their own, and fewer than 10 cases have been reported in the ensuing 5 years [2][3][4][5][6][7]. Fetal loss can occur in utero and, despite appropriate treatment, the case fatality rate approaches 50%.…”

Section: Discussionmentioning

confidence: 99%

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Ascending in Utero Herpes Simplex Virus Infection in an Initially Healthy-Appearing Premature Infant

et al. 2015

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The usual route of acquisition for intrauterine herpes simplex virus (HSV) infection is transplacental. We evaluated a premature infant with in utero acquisition of HSV resulting from ascending infection. Histopathologic evidence of chronic chorioamnionitis and positive staining with immunohistochemistry for HSV in the placenta and umbilical cord established the diagnosis. The clinical presentation was also of interest in that the infant was initially healthy appearing.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ascending in Utero Herpes Simplex Virus Infection in an Initially Healthy-Appearing Premature Infant

et al. 2015

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“…Fetal infection is seen in less than 1% of symptomatic women. 1 Intrauterine growth restriction (IUGR), 2 intracranial calcifications, 1,2 ventriculomegaly, 25 and microcephaly 1,2 can be seen; however, hydranencephaly is more usual with HSV as compared with CMV and toxoplasmosis. 2 Ocular abnormalities, such as microphthalmia 2 and callosal agenesis, 25 have also been described.…”

Section: Herpes Simplex Virusesmentioning

confidence: 99%

Neuroimaging of Fetal Infection

Robinson¹,

Ederies²,

Bailäo³

et al. 2017

J Pediatr Neurol

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Infection during pregnancy is common and the developing fetal brain is vulnerable to vertical transmission due to immaturity of the fetal immune system. Infection is a major cause of multiple organ abnormalities, including the neuraxis, due to the neurotropism of the infectious agents. This review sets out to give an overview of fetal infection, review the general principles of the nature and timing of the infectious insult with respect to outcomes, review the neuroimaging of infection by ultrasound and magnetic resonance imaging (MRI), and review the various pathogens involved, including the two most common, cytomegalovirus (CMV) and Toxoplasma, and also other common viral and nonviral infections.

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“…A su vez, la infección intrauterina es una complicación inusual de la infección por este virus y casi siempre con resultados fatales para el niño 2,3 .…”

Section: Introductionunclassified