A rare case of acquired hepatocerebral degeneration in cirrhosis

Badave, Rohan Ramesh; Basavaraj, Anita

doi:10.4103/ijamr.ijamr_58_16

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2023

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“…As the illness progresses, the liver's detoxifying capacity declines. Shunts in the portosystemic system deliver these dangerous compounds to the brain's bloodstream [4]. Toxic chemicals are deposited in the basal ganglia, which is the pathophysiology of AHD.…”

Section: Discussionmentioning

confidence: 99%

Acquired Parkinson’s Disease in Alcoholic Cirrhosis: The Rarest Association

Dubey¹,

Kumar²,

Acharya³

et al. 2023

Cureus

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Hepatic encephalopathy is the most common neurologic complication of liver cirrhosis, whereas acquired hepatocerebral degeneration (AHD) is an underappreciated neurologic manifestation. Parkinsonism, ataxia, and neuropsychiatric symptoms are its defining characteristics. In individuals with chronic parenchymal liver disease with portosystemic shunting, it is an underrecognized etiology of psychomotor retardation. It has been hypothesized that the etiology of AHD is due to manganese buildup in the basal ganglia. This case report details a hepatocerebral degeneration (AHD) case in a patient with chronic parenchymal liver disease who improved after taking a dopamine agonist.

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Section: Discussionmentioning

confidence: 99%