A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

Nițipir, Cornelia; Ginghină, Octav; Popa, Liliana Gabriela; Andrei, Florin; Tudor, Niculae; Radu, I; Iaciu, Cristian; Orlov, Cristina; Vasilescu, Florina; Bălălău, Cristian; Leon, Grigoris; Negrei, Carolina; Barbu, Maria Alexandra

doi:10.3892/mco.2018.1565

Cited by 10 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, immunohistochemistry is a reliable method to distinguish primary from metastatic gastric cancer. The commonly used markers for subtyping non-small cell lung cancer included TTF-1, CK7, Napsin A for adenocarcinoma, and p63, CK5/6, CK34βE12/CK903 for SCC (38). TTF-1 is highly specific for adenocarcinomas of pulmonary origin exhibiting a positive predictive value of 100% (2,13).…”

Section: Discussionmentioning

confidence: 99%

An ALK-positive lung adenocarcinoma with gastric and skin metastasis: a case report and literature review

2020

View full text Add to dashboard Cite

Primary lung cancer with gastric metastasis is rare to see in the world, little is known about its characteristics. Here, we describe the first case of primary lung adenocarcinoma with gastric and skin metastases along with a review of literature to help clinical decision making. A 49-year-old woman admitted to our department for abdominal distension. The immunohistochemistry staining for the biopsy in the gastric fundus, back and lung showed positive for CK5/6, TTF-1, Napsin A and CK7, but negative for CK20, which strongly indicated all of them were homologous and might originate from lung adenocarcinoma.Chromosome mutation analysis presented an EML4-ALK fusion gene. Brain metastases occurred after 6 months with crizotinib treatment. More than two months later, intracranial lesions became more and larger as she persisted in taking crizotinib plus whole-brain radiotherapy (WBRT). Hence, alectinib was performed due to the continuous growth of brain lesions. When reexamined three months later, the craniocerebral lesions were significantly reduced and all tumor markers were up to normal level. This review comprised 42 published case reports in total. Generally, the average morbidity age was 62 years old, and male with smoking history were more prone to it. It could be found that squamous cell carcinoma (17/38) accounts for a high proportion of gastrointestinal metastases pathology, most of which were poorly differentiated. Surgical excision of the lesions was supposed to improve long-term prognosis, mitigate associated complications, decrease patients' pain, and enhance the quality of life. Gastric metastasis of lung cancer is apt to metastasize to the brain, and the prognosis is inferior. Crizotinib with preventive WBRT may be the optimal choice for NSCLC patients harboring ALK mutation in the initial treatment of gastric metastasis. However, If the lesion in the brain keep on going, timely replacement to alectinib is an appropriate choice.

show abstract

Section: Discussionmentioning

confidence: 99%

An ALK-positive lung adenocarcinoma with gastric and skin metastasis: a case report and literature review

2020

View full text Add to dashboard Cite

show abstract

“…Gastric involvement in metastatic SCLC is rare [2]. Diagnosis of gastric SCLC metastases before primary disease is extremely rare [4]. In our case, the occurrence of nonspecific upper gastrointestinal symptoms with red flag signs prompted an endoscopic evaluation.…”

mentioning

confidence: 89%

A Gastric Lesion Revealing a Small-Cell Lung Cancer: A Rare Case

Mascarenhas

Ribeiro

Moreira

et al. 2021

GE Port J Gastroenterol

View full text Add to dashboard Cite

“…For the third pair of networks, it has been reported that (i) gastrointestinal metastases from lung cancer are diagnosed at a late stage and are thus life threatening 53 , (ii) gastric cancer metastasis results from lung cancer 54 , (iii) gastric cancer is associated with lung cancer [55][56][57][58] , and (iv) both diseases can be successfully treated with carboplatin 59 .…”

Section: Network Similarity -Jensen-shannon Entropymentioning

confidence: 99%

Computational analysis of molecular networks using spectral graph theory, complexity measures and information theory

Huang

Tsai

Kurubanjerdjit

et al. 2019

Preprint

View full text Add to dashboard Cite

Molecular networks are described in terms of directed multigraphs, so-called network motifs. Spectral graph theory, reciprocal link and complexity measures were utilized to quantify network motifs. It was found that graph energy, reciprocal link and cyclomatic complexity can optimally specify network motifs with some degree of degeneracy. Biological networks are built up from a finite number of motif patterns; hence, a graph energy cutoff exists and the Shannon entropy of the motif frequency distribution is not maximal. Also, frequently found motifs are irreducible graphs.Network similarity was quantified by gauging their motif frequency distribution functions using Jensen-Shannon entropy. This method allows us to determine the distance between two networks regardless of their nodes' identities and network sizes.This study provides a systematic approach to dissect the complex nature of biological networks. Our novel method different from any other approach. The findings support the view that there are organizational principles underlying molecular networks. Biological networks and network motifsMolecular biological networks are the basis of biological processes, where the networks exhibit biological functions through interaction among the genetic elements.Each module is expected to perform specific functions, separable from the functions of other modules 1-3 . Such modular networks can be decomposed into smaller clusters, also known as network motifs. These motifs show interesting dynamical behaviors, in which cooperativity effects between the motif components play a critical role in human diseases.Essentially, network-based analysis falls into the following major categories: (1) motif identification and analysis, (2) global architecture study, (3) local topological properties, and (4) robustness of the network under different types of perturbations.For the first category, there are a number of publicly available network motif detection tools, namely MFINDER 4 , MAVISTO 5 , FANMOD 6 , NetMatch 7 and SNAVI 8 .

show abstract

A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

Cited by 10 publications

References 36 publications

An ALK-positive lung adenocarcinoma with gastric and skin metastasis: a case report and literature review

An ALK-positive lung adenocarcinoma with gastric and skin metastasis: a case report and literature review

A Gastric Lesion Revealing a Small-Cell Lung Cancer: A Rare Case

Computational analysis of molecular networks using spectral graph theory, complexity measures and information theory

Contact Info

Product

Resources

About