A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

Sridevi, H B; Shanthala, P R; Raghuveer, C. V.; Prabhu, Ananth K; Akbar, Jallaluddin K C; Shivaprasad, G S; Suresh, Pooja K; Navani, Sanjay

doi:10.4103/0973-1482.139338

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…In spite of the fact that well known in its systemic form including patients with secondary cutaneous involvement, distinguishing primary cutaneous ALCL from its systemic counterpart requires notification upon pathological diagnosis. [ 8 , 9 ]…”

Section: Discussionmentioning

confidence: 99%

Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation

et al. 2018

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Rationale:The rare morphological variant of anaplastic large cell lymphoma (ALCL) may pose a challenge in diagnosis, especially when presentation primarily involves skin lesions.Patient concerns:Here we describe a rare case of small cell variant of ALCL in an 11-year-old girl.Diagnosis:We performed clinical, morphological, and immunohistochemical analyses of developed cutaneous nodules.Interventions:Pathologists should consider this small cell variant in ALCL differential diagnosis, as early and correct diagnosis has important clinical implications.Outcomes:Allogeneic hematopoietic stem cell transplantation appears to be a promising treatment option for small cell variant of ALCL.Lessons:Histological diagnosis of small cell variant of ALCL is challenging among pediatricians because of its low incidence and atypical presentation. We provide a short review of the small cell variant of ALCL to facilitate the diagnosis of this difficult-to-recognize entity.

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Section: Discussionmentioning

confidence: 99%

Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation

et al. 2018

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“…Pierwotnie skórny anaplastyczny chłoniak wielkokomórkowy występuje głównie u osób w wieku podeszłym, 2-3-krotnie częściej u mężczyzn niż kobiet [2]. Opisywano również przypadki wystąpienia choroby u młodych dorosłych [3]. Klinicznie objawia się pojedynczymi (80%) lub mnogimi (20%) guzkami lub guzami o sinoczerwonym zabarwieniu.…”

Section: Wprowadzenieunclassified

“…W piśmiennictwie jest również wiele doniesień na temat dobrych efektów stosowania alternatywnych metod leczenia, m.in. za pomocą INF-α, systemowych retinoidów oraz przeciwciał monoklonalnych anty-CD30 [2][3][4]17].…”

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Primary cutaneous anaplastic large-cell lymphoma in a patient with Hodgkin’s disease – case report

Kozłowska¹,

Baran²,

Flisiak³

2016

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Przegląd Dermatologiczny 2016/3 STRESZCZENIEWprowadzenie. Pierwotnie skórny anaplastyczny chłoniak wielkokomórkowy (ang. cutaneus anaplastic large-cell lymphoma -C-ALCL) należy do rozrostów limfoproliferacyjnych z komórek T CD30+. Przebiega zwykle łagodnie i nie wymaga agresywnego leczenia. Rokowanie w C-ALCL jest dobre, a 10-letnie przeżycie osiąga 90% chorych. U 1/3 pacjentów możliwe są samoistne remisje choroby. Cel pracy. Przedstawienie pacjentki z wywiadem nawrotowej ziarnicy złośliwej, u której rozpoznano pierwotnie skórnego chłoniaka anaplastycznego wielkokomórkowego. Opis przypadku. Pacjentka 35-letnia z wywiadem nawrotowej ziarnicy złośliwej została przyjęta do Kliniki w celu rozpoznania i leczenia zmian skórnych utrzymujących się od kilku tygodni. Na podstawie badania histopatologicznego i immunohistochemicznego rozpoznano pierwotnie skórną postać chłoniaka T-komórkowego. Po 2 tygodniach obserwowano spontaniczną regresję zmian skórnych. Wnioski. Pacjenci z anaplastycznym chłoniakiem wielkokomórko-wym wymagają pogłębienia diagnostyki i ze względu na agresywny przebieg i odmienne postępowanie terapeutyczne wykluczenia postaci układowej choroby, przerzutu chłoniaka Hodgkina do skóry oraz transformacji wielkokomórkowej ziarniniaka grzybiastego. ABSTRACT Introduction.Cutaneous anaplastic large cell lymphoma (C-ALCL) is one of the CD30+ lymphoproliferative disorders. Usually it has a mild course and does not require aggressive treatment. The prognosis in C-ALCL is good, with the 10-year survival rate reaching 90% of patients. Spontaneous remissions of the disease are possible. Objective. To present a patient with recurrent Hodgkin's disease, in whom primary cutaneous anaplastic large cell lymphoma was diagnosed. Case report. A 35-year old woman with recurrent Hodgkin's disease was admitted to the department for diagnosis and treatment of skin lesions, which appeared a few weeks ago. Primary cutaneous T-cell lymphoma was diagnosed by histopathology and immunohistochemistry. After two weeks spontaneous regression of skin lesions was observed. Conclusions. Larger diagnostic procedures and exclusion of the systemic form of ALCL, cutaneous metastases of Hodgkin's disease and large-cell transformation of mycosis fungoides are required due to the aggressive course and different treatment in all cases.Pierwotnie skórny anaplastyczny chłoniak wielkokomórkowy u pacjentki z ziarnicą złośliwą -opis przypadku

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“…The lesion is often slow growing with an indolent clinical course and may present for a long time before being diagnosed [5], and may regress spontaneously in 30% of cases [6]. However clinical presentation can be impressive with the rapid appearance of a single purplish red tumor with necrotic evolution.…”

Section: Open Accessmentioning

confidence: 99%

A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

Elloudi¹,

Elmahi²,

Baybay³

et al. 2016

IJCR

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A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

Cited by 6 publications

References 5 publications

Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation

Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation

Primary cutaneous anaplastic large-cell lymphoma in a patient with Hodgkin’s disease – case report

A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

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