A Rare Case of Anaplastic Transformation Within the Metastatic Site of the Retroperitoneal Region in a Patient 17 Years After Total Thyroidectomy for Papillary Carcinoma of the Thyroid Beginning With Multiple Bone Metastases

Sotome, Keiichi; Onishi, Tatsuya; Hirano, Atsushi; Nakamaru, Makoto; Furukawa, Akio; Miyazaki, Hiroshi; Morozumi, Kunio; Tanaka, Yoïchi; Iri, Hisami; Mimura, Yukihiro

doi:10.1089/thy.2006.0322

Cited by 16 publications

(16 citation statements)

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“…However, no detailed demographic data are available for these reported cases. The groups of Sotome et al [6] and Solomon et al [7] individually reported a single case of anaplastic transformation developed within the metastatic site in the retroperitoneal region. Takeshita et al [8] described anaplastic transformation of p53-positive papillary thyroid carcinoma, in the liver metastasis, following postoperative radioactive iodine therapy.…”

Section: Discussionmentioning

confidence: 99%

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Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Kim

Park

et al. 2016

Head and Neck Pathol

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Anaplastic transformation of papillary thyroid carcinoma (PTC) at distant metastatic sites is extremely rare, and there have been fewer than 20 reported cases in the literature. A 61-year-old woman presented with 1-week history of dyspnea. Her past medical history was remarkable because, 19 years ago, she underwent nearly total thyroidectomy and radical neck dissection due to PTC. Computed tomography of the chest revealed a 1.7 cm nodule in the lung and diffuse pleural thickening. Gun biopsy of the lung nodule revealed metastatic PTC with typical histology. However, the pleural biopsy predominantly showed anaplastic pleomorphic and spindle sarcomatoid carcinoma with microscopic focus of PTC. Immunohistochemical results showed both anaplastic sarcomatoid and PTC components positive for TTF-1, galectin-3 and PAX-8, thus supporting anaplastic transformation of PTC at the metastatic site. Subsequently the patient received 1 cycle of cisplatin-based chemotherapy but died from the disease 4 months after diagnosis. Although it is rare, anaplastic transformation of PTC should be considered during differential diagnosis of patients who present with exclusive sarcomatoid morphology at metastatic sites and have a history of PTC. We report another case of anaplastic transformation of PTC, found at pleural metastasis, together with the immunohistochemical profile and a literature review.

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Section: Discussionmentioning

confidence: 99%

“…To date, fewer than 20 cases of anaplastic transformation at the metastatic sites have been reported in the English literature [1,[4][5][6][7][8][9][10][11]. Here, we report an additional case of anaplastic transformation which developed in the pleural metastasis, combined with a literature review.…”

Section: Introductionmentioning

confidence: 96%

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Kim

Park

et al. 2016

Head and Neck Pathol

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“…Another interesting finding of the patient was the presence of metastatic lesions in the liver, which indicated the anaplastic transformation of thyroid carcinoma. There have been several reports of the anaplastic transformation of PTC in metastatic lesions [ 15 , 16 ], most of which were discovered after RAI therapy. However, the anaplastic transformation in our patient developed 27 months after the final RAI treatment.…”

Section: Discussionmentioning

confidence: 99%

Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer

Yun

Kim

et al. 2014

Endocrinol Metab

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Distant metastases from papillary thyroid carcinoma (PTC) are rare and are associated with a poor prognosis. Here, we describe a patient with metastatic PTC who was treated with a tyrosine kinase inhibitor (TKI, sorafenib) for several months that was acutely exacerbated by discontinuation. A 43-year-old male was diagnosed with PTC in February 2004 and underwent total thyroidectomy followed by two courses of high-dose radioactive iodine (RAI) therapy. Despite two additional courses of high-dose RAI therapy, lung and muscle metastases were developed. Treatment with sorafenib was begun in September 2010. After 11 months treatment of sorafenib, newly developed metastatic lesions were found in mediastinal lymph nodes, liver, and bones. Considered as treatment failure, the administration of sorafenib was discontinued. Two weeks after sorafenib treatment was stopped, the disease progressed abruptly and caused death of the patient by respiratory failure. In our patient, PTC progressed rapidly after the cessation of sorafenib treatment. Patients with several other types of cancer have also experienced such rapid disease progression, termed "flare-ups." Physicians should be aware that flare-ups may occur in advanced PTC patients following the cessation of TKI therapy.

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“…ATC has been found to metastasize to a variety of locations including lung, bone, and brain . A handful of transformed ATC cases were reported in the submandibular gland, retroperitoneum with involvement of pancreas and kidney, liver, skin, and thyroglossal duct cyst …”

Section: Discussionmentioning

confidence: 99%

Case report: Different metastatic components from anaplastic thyroid carcinoma in mediastinal and neck lymph nodes simultaneously diagnosed by FNA

Costaldi

Zhou

2013

Diagnostic Cytopathology

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Anaplastic thyroid carcinoma (ATC) is a rare but aggressive form of undifferentiated thyroid carcinoma which arises from previously well-differentiated thyroid carcinomas, such as papillary carcinoma or follicular carcinoma. We report on an interesting case of ATC found in an enlarging neck mass with metastatic papillary carcinoma found in mediastinal lymph nodes sampled by endoscopic bronchial-ultrasound guided- fine-needle aspiration, due to the incidental finding of a lung mass by CT scan. Divergent morphologies on cytology preparations were resolved by immunohistochemistry, which aided in the identification of both sites of malignancy and the common thread between them. The eventual palliative resection demonstrated the various components including undifferentiated thyroid carcinoma, papillary carcinoma, and background lymphocytic thyroiditis.

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A Rare Case of Anaplastic Transformation Within the Metastatic Site of the Retroperitoneal Region in a Patient 17 Years After Total Thyroidectomy for Papillary Carcinoma of the Thyroid Beginning With Multiple Bone Metastases

Cited by 16 publications

References 0 publications

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer

Case report: Different metastatic components from anaplastic thyroid carcinoma in mediastinal and neck lymph nodes simultaneously diagnosed by FNA

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