A rare case of arterial thrombosis in a 37-year-old male with Factor V Leiden mutation

O’Gorman, Susan M.; Osman, Raed; Smith, M.; Callagy, G; Regan, Mathilda; Kerin, Michael J.

doi:10.1007/s11845-008-0162-y

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Factor V Leiden mutation can cause mesenteric thrombosis but has not been reported in a pregnant patient. 16 The risk of mesenteric thrombosis is higher when other predisposing factors are present such as volvulus, hemorrhage, or a genetic predisposition, as was the case with our patient.…”

Section: Discussionsupporting

confidence: 71%

Massive Small Bowel Resection During Pregnancy Causing Short Bowel Syndrome

Boland

Thompson

Grant

et al. 2011

The American Surgeon™

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Massive small bowel infarction in pregnancy is rare but has devastating complications. Diagnosis is difficult because pregnancy masks the symptoms. Our aim was to assess risk factors and outcomes of massive resection associated with pregnancy. We conducted a review of nine patients with short bowel syndrome (SBS) secondary to massive bowel resection during pregnancy. The most common cause of bowel resection was midgut volvulus in seven patients. Four of these also had malrotation. Three others had previous abdominal operations, including gastric bypass. The two remaining patients had vascular insufficiency. Five of the nine patients presented after a cesarean delivery. There were three fetal deaths. Resulting small bowel length was less than 60 cm in all but one patient. All patients required parenteral nutrition (PN). Seven patients developed significant complications related to SBS and long-term PN. Four patients underwent transplantation. Massive small bowel resection during pregnancy is a devastating complication, which requires a high degree of suspicion to diagnose. Most patients have risk factors, which include previous surgery, congenital malrotation, and a hypercoagulable state. Surviving patients usually need long-term PN or transplantation.

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Section: Discussionsupporting

confidence: 71%

Massive Small Bowel Resection During Pregnancy Causing Short Bowel Syndrome

Boland

Thompson

Grant

et al. 2011

The American Surgeon™

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“…Our work-up revealed that her brother was also FVII deficient and that the patient and her brother respectively had 2 (FV Leiden mutation and protein S deficiency) and 1 (FV Leiden mutation) thrombophilic factors coexistent with FVII deficiency; protein S deficiency with/ without FV Leiden mutation prevailed in the family members. Although the literature contains no solid evidence to support a relationship between FV Leiden mutation and the risk of arterial thrombosis 8 , there are a few exceptional cases with [9][10][11][12] or without 13,14 coexistent thrombophilic factors or disorders. However, we do not know if the paternal grandmother developed myocardial infarction as a rare manifestation of arterial thrombosis due to a possible FV Leiden mutation 13 or due to atherothrombosis, since she was learned not to have undergone replacement therapy or surgical operation before myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…Although the literature contains no solid evidence to support a relationship between FV Leiden mutation and the risk of arterial thrombosis 8 , there are a few exceptional cases with [9][10][11][12] or without 13,14 coexistent thrombophilic factors or disorders. However, we do not know if the paternal grandmother developed myocardial infarction as a rare manifestation of arterial thrombosis due to a possible FV Leiden mutation 13 or due to atherothrombosis, since she was learned not to have undergone replacement therapy or surgical operation before myocardial infarction. As to the serum FVII level (10 to 50 IU/dL), both siblings were in the mild to moderate and heterozygous group, usually expected to be asymptomatic 15 .…”

Section: Discussionmentioning

confidence: 99%

Inheritance of Factor VII and Protein S Deficiency Together with Factor V Leiden Mutation

Bıçakçı¹,

Olcay²

2016

Kafkas J Med Sci

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Below-Knee Amputation Resulting from an Arterial Thrombosis from Tourniquet Use in a Patient with Undiagnosed Factor V Leiden

Hautala

Liu

Hamilton

et al. 2020

JBJS Case Connector

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Case: A 38-year-old woman presented with previously undiagnosed factor V Leiden (FVL), who suffered a complete superficial femoral arterial thrombosis after tourniquet use during the surgical repair of one of her bilateral tibial plafond fractures. This patient's injury eventually resulted in a below-knee amputation. Conclusion: We recommend expanding hypercoagulable screening on patients with risk factors based on a detailed history and physical examination. We also recommend limiting or negating tourniquet use in patients with FVL or other hypercoagulable disorders.

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A rare case of arterial thrombosis in a 37-year-old male with Factor V Leiden mutation

Abstract: Factor V Leiden mutation is a contributing risk factor in cases of small bowel infarction.

Cited by 3 publications

References 9 publications

Massive Small Bowel Resection During Pregnancy Causing Short Bowel Syndrome

Massive Small Bowel Resection During Pregnancy Causing Short Bowel Syndrome

Inheritance of Factor VII and Protein S Deficiency Together with Factor V Leiden Mutation

Below-Knee Amputation Resulting from an Arterial Thrombosis from Tourniquet Use in a Patient with Undiagnosed Factor V Leiden

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