A Rare Case of Bacteremic Community-Acquired Pneumonia Due to Pasteurella Multocida Presenting With Hemoptysis

Ayas, Mohamad Fekredeen; Youssef, Dima; Johnson, Leonard B.

doi:10.7759/cureus.14232

Cited by 4 publications

(5 citation statements)

References 8 publications

(18 reference statements)

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“…Another similar case was reported by Ayas et al which required a great deal of laboratory workup due to the presentation during the COVID-19 pandemic [12]. This case shares similarities with their case of being diagnosed during the COVID-19 pandemic and certain clinical features such as shortness of breath.…”

Section: Discussionsupporting

confidence: 75%

A Case of Pneumonia Caused by Pasteurella multocida in an Immunocompetent Indian Male

Yadav¹

2022

Cureus

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Pasteurella multocida is a common cause of cutaneous and soft-tissue infections. Cases of primary diseases in the lung result from the inhalation of airborne contaminants from infected nasopharyngeal secretions from pets such as cats and dogs. Clinical presentations due to P. multocida vary from a cough with or without hemoptysis or chest pain to severe debility. This is common in elderly populations with existing pulmonary diseases such as chronic obstructive pulmonary disease and bronchiectasis. The present case highlights P. multocida pneumonia in an Indian zookeeper with a pet dog who had no underlying lung pathology. This case emphasizes the significance of a detailed history with a physical examination backed by an extensive laboratory workup as the clinical features of P. multocida pneumonia resemble several common bacterial and viral infections.

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Section: Discussionsupporting

confidence: 75%

A Case of Pneumonia Caused by Pasteurella multocida in an Immunocompetent Indian Male

Yadav¹

2022

Cureus

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“…The respiratory tract is the second most common site of Pasteurella infections, with possible pneumonia, tracheobronchitis, lung abscess, or empyema. Patients with a Pasteurella pulmonary infection are often elderly and have an underlying lung disease, either chronic obstructive pulmonary disease (COPD), bronchiectasis, or malignancy [5][6][7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Bacteremia occurs preferably in immunocompromised patients. Some cases of acute pneumonia due to P. multocida have been reported [6][7][8][9]11,12], but no cases have been reported as a COVID-19 coinfection. The three cases reported here occurred during the same epidemic wave and ended with death in all cases, and thus are a warning to consider P. multocida as a potentially severe coinfection agent.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Pasteurella multocida Pulmonary Coinfection: A Case Series

et al. 2022

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Objectives: In COVID-19 patients, bacterial and fungal pulmonary coinfections, such as Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, or Aspergillus, have been reported, but to our knowledge, no case has been reported due to Pasteurella multocida. Patients and methods: We describe three cases of Pasteurella multocida coinfections occurring during the 4th wave of COVID-19 in Martinique (French West Indies). Results: All three cases were fatal; thus, Pasteurella multocida has to be considered as a potentially severe coinfection agent. Conclusions: Alteration of the epithelial–endothelial barrier due to a SARS-CoV-2 infection probably promotes the expression of a Pasteurella infection. In addition, the SARS-CoV-2 infection induced immunosuppression, and an inflammatory cascade could explain the infection’s severity. The use of corticosteroids, which are part of the first-line therapeutic arsenal against COVID-19, may also promote the pathogenicity of this agent.

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“…P. multocida infects a wide range of animals and causes pneumonia in pigs, cattle and goats, progressive atrophic rhinitis in swine, fowl cholera, and hemorrhagic septicemia in buffalo and cattle (2). It can spread to humans through cat or dog bites, causing severe zoonotic infections (3)(4)(5). The disease type, host specificity, local epidemiology, pathogenicity, and immunogenicity of P. multocida are mainly associated with the nature of the virulence factor capsule (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity and efficacy of serogroup A and D bacterins against Pasteurella multocida in mice

Guan

Yang²,

Xu³

et al. 2023

Front. Vet. Sci.

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IntroductionPasteurella multocida is a widespread respiratory pathogen in pigs, causing swine pneumonia and atrophic rhinitis, and the capsular serogroups A and D are the main epidemic serogroups in infected animals. This study investigated the protective effects of serogroup A and D bacterins against current circulating P. multocida strains, to better understand the immunity generated by bacterins.Method13 serogroup A (seven A: L3 and six A: L6 strains) and 13 serogroup D (all D: L6 strains) P. multocida strains were isolated, and used as inactivated whole cell antigen to prepare P. multocida bacterins. Mice were immunized with these bacterins at 21-day interval and intraperitoneally challenged with the homologous and heterologous P. multocida strains, respectively. The antibody titer levels and immunization protective efficacy of vaccines were evaluated.ResultsAll of the bacterins tested induced high titer levels of immunoglobulin G antibodies against the parental bacterial antigen in mice. Vaccination with the six A: L6 bacterins provided no protection against the parent strain, but some strains did provide heterologous protection against A: L3 strains. Vaccination with the seven A: L3 bacterins provided 50%–100% protection against the parent strain, but none gave heterologous protection against the A:L6 strains. Immunization with the thirteen D: L6 bacterins offered 60%–100% protection against the parent strain, and almost all D: L6 strains gave cross-protection.DiscussionThis study found that the cross-protectivity of serogroup A strains was poor, while serogroup D strains was effective, which provided some insights for P. multocida vaccine development.

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A Rare Case of Bacteremic Community-Acquired Pneumonia Due to Pasteurella Multocida Presenting With Hemoptysis

Cited by 4 publications

References 8 publications

A Case of Pneumonia Caused by Pasteurella multocida in an Immunocompetent Indian Male

A Case of Pneumonia Caused by Pasteurella multocida in an Immunocompetent Indian Male

COVID-19 and Pasteurella multocida Pulmonary Coinfection: A Case Series

Immunogenicity and efficacy of serogroup A and D bacterins against Pasteurella multocida in mice

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