A Rare Case of Behçet Disease Presenting with Pyrexia of Unknown Origin, Pulmonary Embolism, and Right Ventricular Thrombus

Xing, Weili; Swaminathan, G Ashok; Appadorai, D.R.D.; Sule, Ashish Anil

doi:10.1055/s-0033-1347906

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…ICT is more commonly seen in young male patients and usually appears soon after disease onset [ 88 ]. The acute symptoms are usually facial swelling, dyspnea, fever, hemoptysis, and palpitation [ 86 , 89 ]. ICT is frequently associated with pulmonary arterial or venous thrombosis and endomyocardial fibrosis; therefore, it is difficult to demonstrate whether the thrombi are secondary to these conditions or are caused by a de novo process [ 51 ].…”

Section: Imaging Approach To Thoracic Involvement In Behcet’s Diseasementioning

confidence: 99%

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

et al. 2022

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Behcet’s disease (BD) is a chronic systemic inflammatory disorder characterized by underlying chronic vasculitis of both large- and small-caliber vessels. Thoracic involvement in BD can occur with various types of manifestations, which can be detected with contrast-enhanced MSCT scanning. In addition, MR can be useful in diagnosis. Characteristic features are aneurysms of the pulmonary arteries that can cause severe hemoptysis and SVC thrombosis that manifests as SVC syndrome. Other manifestations are aortic and bronchial artery aneurysms, alveolar hemorrhage, pulmonary infarction, and rarely pleural effusion. Achieving the right diagnosis of these manifestations is important for setting the correct therapy and improving the patient’s outcome.

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Section: Imaging Approach To Thoracic Involvement In Behcet’s Diseasementioning

confidence: 99%

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

et al. 2022

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“…The most common location of the PAA is in the right lower lobe branch, as was found in our patient 3 . The presence of pulmonary artery aneurysms correlates with a worse prognosis, with an estimated 30% mortality within two years 5 .…”

Section: Discussionmentioning

confidence: 99%

Pulmonary aneurysms associated with thrombosis in Behçet’s disease: a case report

Lucindo Bolelli de Oliveira,

Horst Duque,

Ribeiro Moulaz

et al. 2024

RBPS

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Introduction: Behçet’s disease is a chronic, multisystemic, inflammatory syndrome characterized by recurrent attacks of oral and genital ulcers, in addition to cutaneous, ophthalmic, central nervous system, gastrointestinal and vascular involvement. Other manifestations may occur more rarely, such as pulmonary artery aneurysm and pulmonary artery thrombosis. Case report: We report a case of a woman presenting with dyspnea and hemoptysis secondary to pulmonary artery aneurysms and pulmonary artery thrombosis caused by Behçet’s disease as the first clinical manifestations. Conclusion: Anticoagulation in thrombosis, without the use of immunosuppressants in patients with Behçet’s Disease, may lead to a poor outcome, as the underlying vasculitis will not be treated. The clinical suspicion of this condition has prognostic implications, especially in atypical presentations, emphasizing the relevance of the theme exemplified in this case report.

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“…Patients commonly present to the hospital with fever, rash, cough, dyspnea, chest pain, weight loss, and hemoptysis. Fever is more common when the pulmonary artery is involved [24][25][26]. In this case, the initial symptoms (2 months before death) were fever and left chest pain.…”

Section: Discussionmentioning

confidence: 99%

Failure of Therapy at Premortem Diagnosed Pulmonary Thromboembolism

Yakar¹,

Yakar²,

Atacan³

et al. 2016

J Clin Exp Invest

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We analyzed patients diagnosed premortem with pulmonary thromboembolism (PTE), focusing on causes of failure of therapy together with clinical characteristics. Methods: This was a retrospective study of 25 cases. We classified PTE as massive, submassive and nonmassive. Results: Of the 25 cases, 76% (19/25) had two or more risk factors for PTE. The point of origin of PE could be determined in only 44% of 25 cases. In 20 % (5/25) of cases diagnosed with PTE a maximum 3 months prior to death, the main cause of death was unknown. Of 10/20 (50%) massive and 8/20 (40%) submassive PTE cases, 5 and 3 underwent thrombolysis therapy, respectively. Both of 2/20 (10%) non-massive PTE cases underwent LMWH; in 1 of these cases, autopsy showed thrombus of a large pulmonary artery at 25 days after therapy. Submassive PTE cases were older and had a greater number of risk factors than did massive PTE cases. The point of origin of PTE was a right heart thrombus in six (24%) cases. Surgeries were performed in 3/6 (50%) cases with right atrial thrombus. The survival duration after therapy in those who underwent surgery was longer than those who received thrombolysis and LMWH therapies. Conclusion: Physicians may provide appropriate information to patients who have certain risk factors (trauma, surgery, pregnancy, etc.) to predict acute PE at a preventable stage. If risk factors are present, or if new risk factors for PTE are identified, patients should be followed up carefully due to the risk of thrombosis progression.

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A Rare Case of Behçet Disease Presenting with Pyrexia of Unknown Origin, Pulmonary Embolism, and Right Ventricular Thrombus

Cited by 8 publications

References 24 publications

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

Pulmonary aneurysms associated with thrombosis in Behçet’s disease: a case report

Failure of Therapy at Premortem Diagnosed Pulmonary Thromboembolism

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