A Rare Case of Bilateral Optic Neuritis and Guillain-Barré Syndrome Post<i>Mycoplasma pneumoniae</i>Infection

Baheerathan, Aravindhan; Russell, Amy Ross; Bremner, Fion; Farmer, Simon F.

doi:10.1080/01658107.2016.1237975

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Simultaneous onset bilateral optic Complete recovery Enlargement of both optic nerves Baheerathan et al 12 13 neuritis and GBS secondary to IVMP and PLEX.…”

Section: Case Reportmentioning

confidence: 99%

Simultaneous combined central and peripheral demyelination with acute inflammatory demyelinating polyradiculoneuropathy and short segment myelitis

Alahakoon,

Nijam,

Weerathunga

et al. 2023

Sri Lanka J. Neurology

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Combined central and peripheral demyelination (CCPD) has been proposed to describe the occurrence of demyelination in both central and peripheral nervous systems. The aetiopathogenesis of combined demyelination is unknown, but the possibility of a shared pathogenic epitope has been suggested. Although it has been described in paediatric patients, reports of simultaneous onset CCPD with short segment myelitis among adults are scarce. We report a case of simultaneous onset monophasic CCPD in an adult who developed both Guillain-Barre syndrome and short segment spinal cord demyelination that responded to immunomodulation with intravenous immunoglobulins and plasmapheresis. The patient also had evidence of chronic thyroiditis which supports an autoimmune aetiopathogenesis of CCPD. Differentiating this diagnosis from multiple sclerosis has therapeutic implications.

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“…Simultaneous onset bilateral optic Complete recovery Enlargement of both optic nerves Baheerathan et al 12 13 neuritis and GBS secondary to IVMP and PLEX.…”

Section: Case Reportmentioning

confidence: 99%

Simultaneous combined central and peripheral demyelination with acute inflammatory demyelinating polyradiculoneuropathy and short segment myelitis

Alahakoon,

Nijam,

Weerathunga

et al. 2023

Sri Lanka J. Neurology

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“…MP is a medium-acting glucocorticoid, which has antiallergic, anti-inflammatory, and immune-regulating effects [13]. In the clinic, MP has been utilized orally and intravenously in the treatment of severe mycoplasma infection, and the effect was promising [14,15]. In this study, the selected children had typical clinical manifestations, such as persistent high fever, which was largely related to an excessive inflammatory response.…”

Section: Adverse Reactionsmentioning

confidence: 99%

The Effect of Methylprednisolone Combined With Macrolide Antibiotics on Mycoplasma Pneumoniae Pneumonia in Children

WANG¹

2022

FARMACIA

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This study aimed to evaluate the clinical efficacy of the combination of methylprednisolone (MP) and macrolide antibiotics (MA) in the treatment of Mycoplasma pneumoniae pneumonia (MPP) in children. Sixty children with MPP were selected as research subjects and were randomly divided into an experimental group and a control group, with 30 patients in each group. The children in the experimental group were treated with MP + MA, and those in the control group were treated only with MA. The treatment efficacy, improvement of clinical symptoms, improvement in the quality of life, and adverse reactions of the two groups of children were compared before and after the treatment. The combination of MP and MA shower increased efficacy compared with the treatment with MA alone (p < 0.05) translated by a shorter time of clinical symptoms alleviation, improved in the quality of life, improve in the levels of tumour necrosis factor α (TNF-α), high-sensitivity C-reactive protein (Hs-CRP), and CD4+ levels. Moreover, in the experimental group it was observed a lower rate of adverse reactions after treatment compared with those in the in the control group (p < 0.05). In conclusion, for the treatment of MPP in children, the combined treatment with MP and MA showed a superior effect, which could improve the clinical treatment effect, relieve the clinical symptoms, effectively shorten the hospital stay, improve the prognosis, promote the improvement in quality of life of children, and enhance the immune function of children. Therefore, it is worthy of clinical application and promotion. RezumatAcest studiu și-a propus să evalueze eficacitatea clinică a combinației de metilprednisolon (MP) și antibiotice macrolide (AM) în tratamentul pneumoniei cu Mycoplasma pneumoniae (MPP) la copii. Au fost selectați șaizeci de copii cu MPP și au fost împărțiți aleatoriu într-un grup experimental și un grup de control, 30 de pacienți per grup. Copiii din lotul experimental au fost tratați cu MP + AM, iar cei din lotul de control au fost tratați doar cu AM. Eficacitatea tratamentului, ameliorarea simptomelor clinice, îmbunătățirea calității vieții și reacțiile adverse ale celor două grupuri de copii au fost comparate înainte și după tratament. Asocierea de MP și AM a crescut eficacitatea față de tratamentul cu AM în monoterapie (p < 0,05), fenomen explicat printr-un timp mai scurt de atenuare a simptomelor clinice, îmbunătățirea calității vieții, scăderea factorului de necroză tumorală α (TNF-α), a proteinei C reactive (Hs-CRP) și optimizarea nivelului de CD4+. Mai mult, în lotul experimental s-a observat o rată mai mică de reacții adverse după tratament, în comparație cu cele din grupul de control (p < 0,05). În concluzie, pentru tratamentul MPP la copii, asocierea de MP și AM a arătat un efect superior, care ar putea îmbunătăți efectul tratamentului clinic, ameliora simptomele clinice, scurta durata spitalizării, îmbunătăți prognosticul, promova creșterea calității vieții copiilor și îmbunătățirea funcției imunitare a copiilor. Prin urmare, este de...

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“…Although optic neuritis has been associated with a vast array of infectious diseases (e.g., varicella zoster virus, influenza virus, herpes simplex virus, Epstein–Barr Virus, cytomegalovirus, West Nile virus, HIV, syphilis, tuberculosis, Lyme disease, Bartonella, and Mycoplasma pneumonia) (1–7), to the best of our knowledge, this is the first case in the English language ophthalmic literature of optic neuritis due to HFMD in an adult.…”

mentioning

confidence: 96%

Postinfectious Optic Neuritis After Hand–Foot–Mouth Disease

Barrett¹,

Bhat²,

Bindiganavile³

et al. 2021

Journal of Neuro-Ophthalmology

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A 33-year-old man presented with acute painless loss of vision in his right eye after hand-foot-mouth disease (HFMD). Examination confirmed a right optic neuropathy. Neuroimaging and routine evaluations for alternative causes for an optic neuropathy were negative. He was treated with high dose corticosteroids and made an almost complete visual recovery. Postinfectious optic neuritis has been reported after a vast array of infections including: varicella zoster virus, influenza virus, herpes simplex virus, Epstein-Barr Virus, Lyme disease, and many others. Although Coxsackie virus infections are a known cause of HFMD and have been reported to cause maculopathy, to the best of our knowledge, this is the first reported case of optic neuritis after HFMD in the English language ophthalmic literature.

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A Rare Case of Bilateral Optic Neuritis and Guillain-Barré Syndrome PostMycoplasma pneumoniaeInfection

Cited by 8 publications

References 16 publications

Simultaneous combined central and peripheral demyelination with acute inflammatory demyelinating polyradiculoneuropathy and short segment myelitis

Simultaneous combined central and peripheral demyelination with acute inflammatory demyelinating polyradiculoneuropathy and short segment myelitis

The Effect of Methylprednisolone Combined With Macrolide Antibiotics on Mycoplasma Pneumoniae Pneumonia in Children

Postinfectious Optic Neuritis After Hand–Foot–Mouth Disease

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