A rare case of brain metastasis from poorly differentiated small bowel adenocarcinoma

Yamazawa, Erika; Honma, Yoshitaka; Satomi, Kaishi; Taniguchi, Hirokazu; Takahashi, Manabu; Yoshida, Akihiko; Tominaga, Koji; Miyakita, Yasuji; Ohno, Makoto; Asanome, Taku; Satomi, Natsuko; Narita, Yoshitaka

doi:10.25259/sni_413_2019

Cited by 2 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patient died in eight months due to recurrent brain metastasis. Another case report reported brain metastasis in jejunal adenocarcinoma in a 54-year-old patient [18].…”

Section: Discussionmentioning

confidence: 98%

A Rare Case of Duodenal Adenocarcinoma With Brain Metastasis

Mani,

Hossain,

Lee

et al. 2024

Cureus

View full text Add to dashboard Cite

Small bowel malignancies are relatively rare, accounting for only 3% of all gastrointestinal cancers. Duodenum is the most common location among small bowel cancers, followed by Jejunum and then Ileum. Duodenal adenocarcinoma produces vague symptoms, leading to late presentation and a poor prognosis compared to similarly staged colon cancer. It is rare to have brain metastasis in duodenal adenocarcinoma, and not many case reports have been reported. Only approximately 6% of patients with gastrointestinal malignancy have brain metastasis. Here, we present a case of a 64-year-old female patient diagnosed initially with stage IV duodenal adenocarcinoma presenting with duodenal mass, abdominal lymphadenopathy, and liver metastasis. She had excellent systemic control for over two years with systemic chemotherapy, with a close to complete response on follow-up imaging. She presented with a 2 cm left frontal mass biopsy consistent with duodenal adenocarcinoma metastasis. She underwent resection of the left frontal tumor and gamma knife to the resection cavity. She continues to have good systemic control of disease. This case highlights the rare possibility of brain metastasis with duodenal adenocarcinoma, especially in patients who have good systemic control with chemotherapy.

show abstract

“…The patient died in eight months due to recurrent brain metastasis. Another case report reported brain metastasis in jejunal adenocarcinoma in a 54-year-old patient [18].…”

Section: Discussionmentioning

confidence: 98%

A Rare Case of Duodenal Adenocarcinoma With Brain Metastasis

Mani,

Hossain,

Lee

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…There are rare reports of SBA with brain metastasis. One such case was reported by Yamazawa et al, who found a poorly differentiated SBA arising from the jejunum with a 38mm cystic metastasis in the left cerebellum [ 9 ]. Salvati et al studied 10 cases of cerebral metastasis with SBA and noted most lesions to be supratentorial [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Adenocarcinoma With Suspected Brain Metastasis

Duhan¹,

Keisham²,

Duhan³

et al. 2023

Cureus

View full text Add to dashboard Cite

Duodenal adenocarcinoma (DA) is a rare tumor. We present the case of an 84-year-old lady who presented with episodic emesis with progressive dysphagia to solids and liquids. She also noted a significant weight loss of 31kg over four months. She was reported to have multiple brain masses three months before this admission. A computed tomography (CT) scan showed a heterogeneous mass (8cm) in the left retroperitoneum, inseparable from the duodenum. Additional peritoneal nodules and enlarged retroperitoneal lymph nodes were suspicious for metastases. Esophagogastroduodenoscopy revealed extrinsic compression of the stomach by the tumor. A large friable distal duodenal mass (fourth part) partially obstructed the lumen, which was biopsied. Pathology results demonstrated high-grade dysplasia but did not confirm malignancy. The patient's carcinoembryonic antigen (CEA) was elevated, but cancer antigens (CA)125 and CA19-9 were normal. A percutaneous biopsy of the mass revealed enteric-type adenocarcinoma. Immunohistochemistry showed that the tumor was positive for caudal-type homeobox (CDX)2, negative for special AT-rich sequence-binding protein (SATB)2, and patchy positive for cytokeratin (CK)7 and CK20 staining. The collective evidence suggested a duodenal primary. The patient opted for hospice and died in three days. We lack pathological evidence, but the patient's brain masses were suspicious of metastases. This would be one of the few reported cases of DA with possible brain metastases.

show abstract

A rare case of brain metastasis from poorly differentiated small bowel adenocarcinoma

Cited by 2 publications

References 10 publications

A Rare Case of Duodenal Adenocarcinoma With Brain Metastasis

A Rare Case of Duodenal Adenocarcinoma With Brain Metastasis

Duodenal Adenocarcinoma With Suspected Brain Metastasis

Contact Info

Product

Resources

About