A rare case of breast carcinoma presenting with paraneoplastic cerebellar degeneration

Eseonu, Kelechi; Imtiaz, Fawzia; Hogben, Katy

doi:10.1093/jscr/2010.10.6

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimulation of stem cells in the bone marrow to produce red blood cells occurs due to the action of erythropoietin which is a glycoprotein hormone (Ohisson and Aher, 2009). This report corroborates the report of Eseonu et al (2010). They reported that the leaves of Peristrophe bicalculata (petz) are capable of improving red blood cell counts in experimental animals.…”

Section: Haematological Profilesupporting

confidence: 92%

Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

Ogunka-Nnoka¹,

Abbey²

2019

Braz. J. Biol. Sci.

View full text Add to dashboard Cite

The study evaluates the bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on the haematological profile of paracetamol-induced Wistar albino rats. Standard methods were used in the proximate, phytochemical and haematological profile analysis. The results of the proximate composition revealed high values for crude fiber (49.13%), carbohydrates (16.33%) and protein (10.94%). Phytochemical studies showed the presence of alkaloids, flavonoids, saponins, phenols and tannins within the concentration range of 0.0003-94.68 µg/mL. Twenty-four hours after the last oral administration, the rats were sacrificed. Blood was obtained by cardiac puncture. Results of the haematological profile at different dose levels (200 mg/kg, 300 mg/kg and 500 mg/kg body weight) did not show any significant difference (p > 0.05) when compared with the control. A slight increase was observed in the erythrocytes (red blood cells, haemoglobin, packed cell volume and platelets). Meanwhile, a significant increase (p ≤ 0.05) was observed in the WBC and platelets of the groups induced with paracetamol only. However, administration of ascorbic and the sample extract reduced the white blood cells and platelet levels. The study revealed that M. barteri leaves contain an appreciable amount of nutrients, bioactive constituents and may serve as a blood booster.

show abstract

Section: Haematological Profilesupporting

confidence: 92%

Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

Ogunka-Nnoka¹,

Abbey²

2019

Braz. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…anti-Yo, anti-Ri(Table 2). [9][10][11][12][13][14][15][16][17][18][19][20][21] Anti-Yo Ab is the commonest Ab associated with PCD, which is usually present in patients with breast or ovarian neoplasm. Greenlee and Brashear (1983) first identified anti-Yo antibody against Purkinje cells in patients with PCD.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Associated Anti Yo-Antibody Mediated Paraneoplastic Cerebellar Degeneration: Case Series and Review of Literature

Mudassir

Kumar

Sinha

et al. 2022

MNJ

View full text Add to dashboard Cite

Paraneoplastic cerebellar degeneration (PCD) is a rare immune mediated disorder characterized by progressive cerebellar ataxia in presence of onconeural antibodies which occurs due to an indirect effect of underlying malignancy i.e. small cell lung cancer (SCLC), breast and gynecologic cancer, and Hodgkin lymphoma. In about 50% of patients neurological manifestation of Paraneoplastic cerebellar degeneration occurs prior to detection of carcinoma. Anti-Yo Antibody is the commonest antibody present in patients with Paraneoplastic cerebellar degeneration which is associated with breast carcinoma. We describe 3 female patients with anti YO antibody mediated PCD with breast cancer. One patient had a previous diagnosis of breast cancer with post mastectomy status one year back. Two of them presented with ataxia and on further examination, breast lump was found. All three patients had symmetrical ataxia with one patient had severely debilitating ataxia and was not able to walk unassisted. Magnetic resonance imaging brain showed cerebellar atrophy in two patients while one patient had normal MRI. Anti- YO antibody was strongly positive in all the three patients. All patients were given immunotherapy (corticosteroids in 2, Intravenous immunoglobulin in 1) with 1 patient showed modest improvement These case highlights the need to consider for workup for paraneoplastic cerebellar degeneration in female patients presenting with subacute to chronic progressive ataxia, so that the tumors can be detected and treated in early stage with a good outcome.

show abstract

Occult Breast Carcinoma Presenting With Anti-Ri-Associated Paraneoplastic Cerebellar Degeneration Revealed With FDG-PET

Bazine¹,

Fetohi²,

Berri³

et al. 2014

CCO

View full text Add to dashboard Cite

Paraneoplastic neurological syndromes are rare diseases affecting less than 0,01 % of the cancerous patients.Here, we present a rare case of paraneoplastic cerebellar degeneration with anti-Ri antibodies as the presenting manifestation of an occult breast cancer. Our observation emphasizes the importance of the nature of the anti-neuronal antibody and the fluorodeoxyglucose-positron emission tomography to make a definitive diagnosis in patients with subactue onset of neurological deficit suggesting paraneoplastic cerebellar degeneration.

show abstract

A rare case of breast carcinoma presenting with paraneoplastic cerebellar degeneration

Abstract: This case report highlights the importance of a high index of suspicion for breast cancer in a young patient with rapidly progressive neurological dysfunction, a family history of breast cancer and an asymptomatic breast lump.

Cited by 3 publications

References 10 publications

Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

Breast Cancer Associated Anti Yo-Antibody Mediated Paraneoplastic Cerebellar Degeneration: Case Series and Review of Literature

Occult Breast Carcinoma Presenting With Anti-Ri-Associated Paraneoplastic Cerebellar Degeneration Revealed With FDG-PET

Contact Info

Product

Resources

About