A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report

Abstract

Background: Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor and has the characteristics of destructive growth pattern, high recurrence rate and easy canceration. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported so far. Case Presentation: A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period, SIP was found twice and both underwent endoscopic left nasal tumor resection. The clues that the diseases were found were the abnormal rise of squamous cell carcinoma antigen (SCCA). SCCA level decreased to normal after operations.Discussion and Conclusion: (1) when the cervical lesions have resolved satisfactorily but the SCCA is still high, other sites should be promptly investigated for the cause, which may lead to earlier detection and earlier treatment of SIP. (2) Combined with the literature, we recommend that SCCA can be used as a routine monitoring index for SIP. If available, a combination of SCCA1 and SCCA2 can be tried for further judgement. (3) For SIP with a high recurrence rate, can anti-HPV treatment be taken after operation to reduce the risk of recurrence?