2015
DOI: 10.4103/0976-9668.149209
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A rare case of clear cell variant of oral squamous cell carcinoma

Abstract: Oral squamous cell carcinoma with prominent clear cell differentiation is a rare occurrence. A 35-year-old female patient presented with a nonhealing ulcer persistent for 1-month involving the left lateral border of the tongue and lingual vestibule. Lobules of malignant squamous epithelial cells with abundant cytoplasm and vesicular nuclei in the connective tissue were observed following histopathology. Neoplastic cells constituting majority of lobules exhibited clear cell changes. Periodic acid-Schiff and muc… Show more

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Cited by 15 publications
(10 citation statements)
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“…The clear cells were negative for PAS, mucicarmine, and Oil Red O, indicating the absence of glycogen, mucin and lipids, respectively [33]. The most recent case as described by Kaliamoorthy et al in 2015, presented as a non-healing ulcer on the left lateral border of the tongue that showed malignant histologic criteria with prominent clear cell changes that were negative for PAS and mucicarmine [34]. Table 2 summarizes previous cases of clear cell squamous cell carcinoma originating from oral surface epithelium.…”
Section: Discussionmentioning
confidence: 99%
“…The clear cells were negative for PAS, mucicarmine, and Oil Red O, indicating the absence of glycogen, mucin and lipids, respectively [33]. The most recent case as described by Kaliamoorthy et al in 2015, presented as a non-healing ulcer on the left lateral border of the tongue that showed malignant histologic criteria with prominent clear cell changes that were negative for PAS and mucicarmine [34]. Table 2 summarizes previous cases of clear cell squamous cell carcinoma originating from oral surface epithelium.…”
Section: Discussionmentioning
confidence: 99%
“…Student's two-sample t-test was used to determine significance between average age of diagnosis between gender groups. All cases of SCC (7,591) and SCCIS (10,247) were read between the dates of 1/2016-6/2018 at CSP. Of these cases, only 107 had clear cell change (30 invasive SCC and 77 ccSCC in situ) representing 0.6% of the total SCC cases read at CSP.…”
Section: Discussionmentioning
confidence: 99%
“…Review of the literature and this study of ccSCC do not indicate if the degree of clear cell change correlates with prognostic outcomes in comparison with other clear cell lesion subtypes, such as the odontogenic, salivary, oral squamous cell and metastatic variety; all of which are known to have a more aggressive biologic behavior. 10,11 The literature on ccSCC to date suggests that this subtype has an intermediate potential for metastasis when compared to other SCC subtypes but more studies are needed to better understand ccSCC behavior. 2 In summary, this study validates past observations that ccSCC occur more commonly in elderly individuals in areas of high photo-exposure such as the head and neck.…”
Section: Discussionmentioning
confidence: 99%
“…[ 1 ] Clear-cell SCC (CCSCC) is a rare entity, and a total of seven cases are reported in skin. [ 3 ] An exhaustive search on Google Scholar produced only four cases in the oral cavity till date, of which two are glycogen free, like ours indicating the rarity of this oral variant[ 1 2 4 5 ] [ Table 1 ]. Thus, the reported case is the third well-documented case of glycogen-free clear-cell variant of oral SCC in English literature and the first case in maxilla, and thereby being a rare entity, it is making an important contribution to the knowledge regarding this uncommon lesion in oral cavity.…”
Section: Introductionmentioning
confidence: 95%
“…Other histologically recognized variants of oral SCC include verrucous, spindle, adenosquamous and basaloid. [ 2 ] Neoplasms with prominent clear-cell component in oral cavity are very rare and usually represent as a variant of salivary gland tumors or the result of renal metastasis. [ 1 ] Clear-cell SCC (CCSCC) is a rare entity, and a total of seven cases are reported in skin.…”
Section: Introductionmentioning
confidence: 99%