A rare case of erythema elevatum diutinum presenting as diffuse neuropathy

Nguyen, Giang Huong; Guo, Emily L.; Norris, David A.

doi:10.1016/j.jdcr.2016.10.007

Cited by 12 publications

(29 citation statements)

References 10 publications

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“…This is in contrast to medium‐sized or large arteries typically affected by polyarteritis nodosa. LCV is rarely accompanied by neurological complications, particularly neuropathy (LCV/EED neuropathy) . Here, we report such a rare case.…”

Section: Introductionmentioning

confidence: 84%

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Leukocytoclastic‐vasculitic neuropathy

Shimizu

Sakakibara

Takahashi

et al. 2019

Neurology & Clinical Neurosc

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We report the case of a 46‐year‐old Japanese woman with leukocytoclastic vasculitis (LCV) neuropathy who presented with skin symptoms (skin ulcers and livedo reticularis) and multiple mononeuropathies of the axonal degeneration type. Intravenous methylprednisolone pulse therapy and subsequent oral prednisolone and warfarin gradually ameliorated all her clinical symptoms. Although rare, neuropathy is an important clinical manifestation of LCV.

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Section: Introductionmentioning

confidence: 84%

“…Nguyen et al reported a 56‐year‐old woman with LCV/EED neuropathy. A skin biopsy showed capillary vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Leukocytoclastic‐vasculitic neuropathy

Shimizu

Sakakibara

Takahashi

et al. 2019

Neurology & Clinical Neurosc

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“…Typically, it presents with persistent red, raised nodules, and plaques in a symmetrical acral distribution . EED is a benign chronic vasculitis of unknown etiology that involves mostly the extensor surfaces of extremities with variable clinical presentation . It might present as asymptomatic lesions or as either pruritic nodules and/or plaques.…”

Section: Introductionmentioning

confidence: 99%

“…1 EED is a benign chronic vasculitis of unknown etiology that involves mostly the extensor surfaces of extremities with variable clinical presentation. 2,3 It might present as asymptomatic lesions or as either pruritic nodules and/or plaques. The morphological appearance of these lesions correlates well with the repair/fibrosis that follows the initial inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…The reported associated causes of EED include bacterial (ie, streptococcal infection and tuberculosis), viral infections (ie, human immunodeficiency virus (HIV) and hepatitis B virus), rheumatologic diseases, and hematologic neoplasms. 3,7,8 Within the viral infections, HIV infection has been reported as one of the most common associated causes of EED; even being considered initially an emerging pathognomonic HIVrelated dermatosis. 9 EED has been associated also to immune reconstitution inflammatory syndrome, seen in HIV patients.…”

Section: Introductionmentioning

confidence: 99%

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Erythema elevatum diutinum a rare and poorly understood cutaneous vasculitis: A single institution experience

et al. 2018

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Background Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED. Methods We retrospectively analyzed five cases in a single institution collected over a period of 27 years. The clinical history was collected and all the slides were examined to determine the histopathological characteristics of the lesions. Results The mean age of our patients is 56.6 years. Two of five patients were females and with lesions showing predilection for the upper‐extremities. The most common presentation was of an erythematous plaque on the extensor surfaces. Three patients had a history of neoplasm. All cases showed leukocytoclastic damage consistent with EED. Conclusion Our findings suggest that EED shows a heterogeneous clinical and pathological presentation, which can show an overlap with granulomatous dermatoses and mixed connective tissue diseases. Scalp lesions can occur and can mimic granulomatous dermatoses. The finding of EED in benign and malignant solid tumors in three of our patients begs the question whether there is an association between EED and such solid neoplasms.

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